PLoS ONE
Articles in this Issue
Evaluation of the effect of olive extracts on blood pressure and cardiovascular health markers in adults: Findings from a double-blind, placebo-controlled, randomised trial
Despite advances in reducing cardiovascular disease (CVD) incidence, CVD mortality has increased, emphasising the need for new preventive strategies. Polyphenol-rich olive extracts have been proposed...
Physical function, daily activities, and spinal pain in the elderly: A cross-sectional study
Population aging is associated with progressive functional decline and a rising prevalence of chronic spinal pain, representing a major challenge for public health and geriatric care....
A scoping review of “Tang ping” (Lying flat) and mental health status among Chinese youth
"Tang ping" has become a common phenomenon among Chinese youth. The mental health status caused by "Tang ping" has been discussed in many articles, but there has been no scoping review of the research...
Anisotropic fracture mechanics of pre-cracked T4,4,4-Graphyne Nanosheets: Effects of crack geometry and temperature
An atomistic study is conducted to elucidate the fracture behavior of pristine and centrally pre-cracked T 4,4,4 -graphyne nanosheets (150 Å × 150 Å) under unia...
Proteomics-based biomarkers of plasma exosomes from patients with acute myocardial infarction
Purpose This study aimed to identify plasma exosomal protein biomarkers for early recognition of acute myocardial infarction (AMI) using label-free quantitative proteomics....
Analyzing the comparative effectiveness of educational methods to foster children’s dengue knowledge
Education about dengue disease is fundamental for its prevention. However, the most effective methods for delivering this knowledge in schools remain unclear. In this study, we compared two widely use...
“A very first clue on the subject”: A focus group study on users’ perspectives on German plain language summaries of psychological meta-analyses
Background Plain Language Summaries (PLSs) are textual summaries of scientific studies that are targeted at lay audiences. PLSs of psychological meta-analyses may benefit laypeople...
Covariation between air chiller and chicken product microbiota in a poultry processing facility
Chicken products are prone to microbial spoilage, and early detection of deviations in contaminating microbiota can improve quality while reducing waste and customer complaints. In industrial poultry...
Measuring representation in clinical trials: Simulations demonstrating how current methods fail in the context of precision medicine
Clinical trial representativeness is vital for the evaluation of intervention performance and study generalizability. Current methods for evaluating representativeness are limited by the quality of th...
Glucocorticoids suppress early lung inflammation and impair control of SARS-CoV-2 in non-human primates
In severe cases of COVID-19, glucocorticoid treatment improves clinical outcomes. However, in non-hospitalized patients, glucocorticoids have limited benefit and may impair viral clearance. Here, we u...
Research on electromagnetic compatibility analysis of automation equipment based on generative adversarial networks and pulse sparse convolution
Electromagnetic interference (EMI) analysis in high-speed industrial systems is increasingly challenged by multi-gigahertz sampling rates, complex transient behaviors, and stringent real-time constrai...
“They don’t feel what I feel”: lived experiences of women accessing comprehensive abortion care in pastoralist communities of Oromia region, Ethiopia: A Phenomenological study
Background Unsafe abortion is a significant global health concern, contributing to high rates of maternal mortality, particularly in developing countries. Women in pastoralist comm...
Physiological responses of sea urchin, Arbacia punctulata, exposed to temperature and lipopolysaccharides (LPS)
Sea urchins are interesting creatures that play important ecological roles in the sea and are popular for their culinary and medicinal uses, which belong to phylum of Echinodermata. However, rapid env...
Functional study of two flexible regions of the hepatitis E virus ORF1 replicase
Hepatitis E virus (HEV), like other positive-sense RNA viruses, encodes a multidomain protein essential for replication, termed ORF1. However, the number, organization, and functions of its domains re...
The biodegradable mGnRHa-Poly[lactic-co-glycolic acid] microparticles enhances semen quality in multi-stripped rainbow trout
To reduce reproduction costs, broodstock undergo multiple stripping, during which semen quality gradually declines toward the end of the spawning season. One potential solution is the use of slow-rele...
Systemic inflammatory response index is associated with acute kidney injury following cardiac surgery: A retrospective cohort study using the MIMIC database
Purpose This study aimed to investigate the association between the Systemic Inflammatory Response Index (SIRI) and acute kidney injury (AKI) following cardiac surgery using the Me...
Correction: Endocrine advantages of PD-1/PD-L1 therapy: Comparative analysis of FAERS-JADER
Correction: Hematological and biochemical alterations in preeclampsia: Readings from cord blood analysis
Baobab isotope records and rainfall forcing in Southwest Madagascar over the last 700 years
Highly resolved climate records for Madagascar are scarce but are essential for understanding of rainfall drivers over time and assessing the risks and likely trajectories of future climate change. We...
Minimum standards for physical therapists providing rehabilitation care for people with chronic respiratory diseases in Japan: An e-Delphi study
Symptom experiences of patients after cardiac valve surgery: A qualitative study
Introduction Heart valve disease is a leading cause of morbidity and mortality worldwide, with surgery being the gold standard treatment.Although clinical management focuses on pos...
Single-cell omics reveals arg-1 as a key regulator of age-dependent macrophage-mediated cartilage repair
Aging impairs cartilage repair, with young animals exhibiting superior regenerative capacity due to enhanced tissue repairing and reduced inflammation compared to aged counterparts. This study employe...
Association between family nurturing environment and screen exposure among preschool children aged 3–6 years in Shanghai: A cross-sectional study
Background Excessive or early screen exposure has been deemed associated with both immediate and long-term health impairment among preschool children. This study aimed to investiga...
Correction: Protocol of a multi-centre randomized controlled trial to compare pericapsular nerve group block, fascia-iliaca compartment block and femoral nerve block for pain management in patients with a hip fracture in the emergency department (CPFF-ED)
Computational modelling of the equine arteritis virus GP5/M Dimer: Implications for immune evasion and virulence
Equine arteritis virus (EAV) is a positive-stranded RNA virus of the Arteriviridae family. Its GP5/M dimer, the principal component of the viral envelope, mediates virus budding and serves as a key ta...