PLoS ONE
Articles in this Issue
From genes to diagnosis: The impact of UNC5B and DOK5 in intracranial aneurysm detection and pathogenesis
Objective Intracranial aneurysms exhibit a notable prevalence within the general population, characterized by an incidence rate ranging from 1% to 2% and an annual rupture rate of...
Obstructive sleep apnea and outcomes in acute pulmonary embolism: A large-scale database study
Study objectives To evaluate the impact of obstructive sleep apnea (OSA) on outcomes of acute pulmonary embolism (PE). The primary objective was to compare 30-day mortality and inc...
TSSpredator-Web: A web-application for transcription start site prediction and exploration
Background With the rapid development of high-throughput RNA-seq technologies, the transcriptome of prokaryotes can now be studied in unprecedented detail. Transcription start site...
Plasma lipidomics, choline metabolites, and metabolic-associated steatotic liver disease (MASLD): A Coronary Artery Risk Development in Young Adults (CARDIA) study
Metabolic-associated steatotic liver disease (MASLD) is marked by accumulation of hepatic triacylglycerols (TAG), but many other lipids have been implicated. Choline metabolism has been shown to be re...
Prevalence of stunting and its determinants among children under five in 35 Sub-Saharan African countries (2011–2024): Insights from recent demographic health survey data using a generalized linear mixed-effects model with robust poisson regression
Background Despite efforts by initiatives like the World Bank’s ‘All Hands-on Deck’ and UNICEF’s programs to address stunting through multisectoral approaches, the burden of stunti...
Associations of cardiovascular risk factors with handgrip strength and gait speed among older males and females: A systematic review protocol
Introduction Cardiovascular risk factors (CRFs), such as hypertension, diabetes, dyslipidemia, and smoking are associated with several adverse health outcomes among older people, s...
Implementing a novel PAM-4 modulation/demodulation scheme along with source and link protection in a high capacity data center architecture
Desirable data-center features include cost efficiency, high bandwidth, scalability, and protection against component failures. In this study, we propose an architecture that employs a small number of...
Understanding effectiveness of a low-cost food package for ensuring food security during the COVID-19 at the household level: Difference-in-differences analyses of a quasi-experimental trial in Bangladesh
Introduction The emergence of COVID-19 pandemic compelled to undertake a ‘lockdown or shutdown’ approach to control the spread of the virus. People from resource-limited settings e...
Decisions and choices about fertility and family planning: Perspectives from husbands and wives in Sudan
Background The use of family planning contraceptives is an essential feature of reproductive health and rights, and safeguards women’s health. Sudan is among the countries with the...
Prevalence and risk factors of cholelithiasis in patients with spinal cord injury: A cross-sectional analysis
Objective The purpose of the present study was to investigate the incidence of cholelithiasis and evaluate the risk factors for cholelithiasis in patients with spinal cord injury (...
IRN2Vec: A representation learning model for road network intersections by integrating geospatial attributes and travel behaviors
The structural characterization of road networks serves as a critical foundation for enabling high performance in intelligent transportation systems. This paper proposes IRN2Vec, an intersection-orien...
Expression of Concern: Local vs. systemic administration of bisphosphonates in rat cleft bone graft: A comparative study
A comparison of the existing recommendations for human and veterinary clinicians on the management and prevention of the zoonotic aspects of dermatophytosis: A scoping review
Background Dermatophytosis (or ringworm) is a highly infectious zoonotic disease commonly found in humans and multiple animal species globally. With children under 5 years of age b...
Lessons learned from manual curation of thousands of gene models in the nematode Pristionchus pacificus
Continuous developments in sequencing technologies have led to the generation of chromosome-scale genome assemblies across the whole tree of life, but our ability to annotate genomes has lacked behind...
A cluster of acidic residues in the cytoplasmic domain of SARS-CoV-2 Spike is required for virion-incorporation and infectivity
Like all coronaviruses, the infectivity of SARS-CoV-2 virus particles (virions) requires incorporation of the Spike glycoprotein. Yet, the mechanisms that support the virion-incorporation of Spike are...
Effectiveness of the influenza and Tdap vaccination educational module (InTroDuce-Programme) on knowledge and intention for antenatal vaccination: A cluster randomised controlled trial protocol among pregnant women in Malaysian primary care clinics
Background Vaccination during pregnancy represents a critical public health strategy to safeguard both mothers and infants against infections such as influenza and pertussis. Howev...
Early administration of renin–angiotensin system inhibitors improves survival and cardiac remodeling in heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) is a major cardiovascular disease that accounts for 50% of all cases of heart failure. Patients with HFpEF have limited therapeutic options becau...
Higher serum zinc micronutrient levels are associated with reduced susceptibility to Group B Streptococcus rectovaginal colonisation in pregnant women
Background Maternal recto-vaginal colonisation by Group B Streptococcus (GBS) is a major risk factor for severe i...
Beyond writing machines: A Kano model analysis of researchers’ hierarchical needs for AIGC services across the research lifecycle
The proliferation of AI-Generated Content (AIGC) tools presents both opportunities and challenges for the academic service ecosystem. However, a systematic understanding of researchers’ multifaceted d...
Editorial Note: Data augmentation-assisted deep learning of hand-drawn partially colored sketches for visual search
Cosmopolitan no more: Phylogenetics and reproductive mode reveal a global species complex in a marine mollusk (Teredinidae)
Quantifying biodiversity is challenging when morphology is conserved in taxa with extensive geographic distributions generated in part by human activities. Shipworms, xylophagous wood-boring clams, ha...
Preoperative expiratory muscle training for swallowing function in patients with esophageal cancer undergoing esophagectomy: A randomized controlled phase II trial protocol
Esophagectomy is a highly invasive and curative procedure for esophageal cancer. Although minimally invasive techniques reduce the incidence of pulmonary complications, postoperative dysphagia remains...
Integrative transcriptomics unravels the central role of fatty acid elongation in early cotton fiber development
Cotton fiber initiation is a critical determinant of yield and quality. To decipher the genetic networks underlying this process, we conducted a time-series transcriptome analysis of a wild-type cotto...
Exploring the aesthetic cognition and artistic acceptance of AIGC-generated urban sculptures: A structural equation modeling and visual content analysis approach
As artificial intelligence–generated content (AIGC) becomes increasingly integrated into creative practices, its application in public art—particularly in urban sculpture—raises fundamental questions...
A transfer learning approach for automatic conflicts detection in software requirement sentence pairs based on dual encoders
Software Requirement Document (RD) typically contains tens of thousands of individual requirements, and ensuring consistency among these requirements is a critical prerequisite for the success of soft...