PLoS ONE
Articles in this Issue
Comparative analysis of the characteristics, care pathways, and outcomes of English and Welsh major trauma patients injured by high versus low energy transfer mechanisms in 2019
Background Recent trends in high-income countries indicate a shift in the causes of major trauma, with low-energy transfer mechanisms, particularly falls from less than two meters,...
Combining lenalidomide with IL-2 family of cytokines enhances activating receptor and perforin/granzyme expression in NK cells
Background Lenalidomide is an immunomodulatory drug approved in the treatment of autoimmune disease, inflammation, and cancer. Its impact continues to grow due to its diverse spect...
Wealth, health, and happiness: An inverse story of the Easterlin Paradox in China
One popular explanation for the Easterlin paradox is that income growth over time is usually accompanied by industrialization and pollution, which cause damage to happiness that cannot be reflected by...
Study on the formation mechanism of color and flavor during the processing of Polygonatum cyrtonema Hua (PCH)
This study elucidated the formation mechanism of color and flavor in Polygonatum cyrtonema Hua (PCH) processing, corrected the traditional view that the Maillar...
Dosimetric benefits of 1.5 T MR-guided radiotherapy in partial breast treatment
This study aimed to evaluate the dosimetric benefits of magnetic resonance (MR)-guided radiotherapy (MRgRT) compared to computed tomography (CT)-guided RT for partial breast treatment. First, treatmen...
Cure rate estimation with insufficient follow-up: A median-based bootstrap correction approach
The cure rate in clinical trials can be estimated using the Kaplan–Meier (KM) estimator. However, when the clinical trial follow-up period is insufficient and short, the KM estimator may overestimate...
Asian-White racial disparities in postpartum hemorrhage and severe postpartum hemorrhage in Ontario, Canada: A population-based cohort study
Background Postpartum hemorrhage (PPH) is the leading preventable cause of maternal morbidity and mortality globally, occurring in 4–6% of Canadian deliveries with evidence suggest...
DS-Mamba: Depthwise separable mamba for hyperspectral image classification
Transformers experience quadratic computational complexity in hyperspectral image (HSI) classification tasks, which can result in error propagation and memory usage issues. Recently, Mamba architectur...
Time restricted EAting for Type 2 diabetes and MEtabolic health: The TEA TIME trial study protocol
Background Recent findings have suggested that implementing the emerging weight-loss strategy of time-restricted eating (TRE) for 6 weeks can have beneficial effects on the key pat...
External-knowledge enhanced dual encoder and contrastive learning for aspect sentiment triplet extraction
Aspect Sentiment Triplet Extraction (ASTE) is an emerging subtask of Aspect-Based Sentiment Analysis (ABSA), aiming to extract aspect terms, opinion terms, and the corresponding sentiment polarity fro...
Exendin-4 enhances GLP-1 signaling and reduces anxiety-like behaviors in male heroin withdrawal mice
Anxiety and depression significantly contribute to heroin relapse, and addressing these issues could lower relapse rates. The basolateral amygdala (BLA) and nucleus tractus solitarius (NTS) are involv...
Species specific marker genes for systemic defence and stress responses to leaf wounding and flagellin stimuli in hybrid aspen and silver birch
In Northern Europe, climate warming is driving the northward expansion of deciduous tree species such as aspen and silver birch, while simultaneously intensifying biotic stress from pests and pathogen...
pH-dependent structural dynamics of neuropeptide Y in aqueous solution
Neuropeptide Y regulates key molecular processes in the brain. Its interaction with the cell membrane, where it binds to specialized receptors with key physiological roles, likely depends on pH. Avail...
Evaluating others’ well-being: Survey experiment on fictional Japanese celebrities generated from wikipedia articles and ChatGPT
Well-being attracts scholars’ and policymakers’ interests for decades. This study examines how respondents evaluate a “Good Life,” “Happy Life,” and “Meaningful Life” through the analysis of fictional...
Predatory activity and nematocidal compounds released into liquid culture filtrates as attack strategies of a Mexican strain of Arthrobotrys oligospora against Haemonchus contortus infective larvae
Nematophagous fungi offer a sustainable alternative for controlling nematode infections in small ruminants. The aims were to isolate and characterize both morphological and molecular nematophagous fun...
Person-centered strategies for integrating TB treatment into community pharmacies for people with TB/HIV in Uganda: A human-centered design methodology study protocol
Background Community pharmacies (private retail drug shops or pharmacies) have successfully delivered antiretroviral therapy (ART) to people with human immunodeficiency virus (HIV)...
Communication competences of multiple sclerosis neurologists during advance care planning conversations: A multi-observer study
Background The ConCure-SM intervention [ISRCTN48527663] consists of an advance care planning (ACP) training program for neurologists/other professionals caring for people with prog...
Factors influencing job satisfaction and turnover intention among nurses in the UAE
Job satisfaction and turnover intention are critical factors influencing nurse retention and healthcare outcomes. This study explores the impact of organizational policies, work environment, patient c...
A cost-effective breast cancer screening strategy for Urban China: Findings from a Shenzhen-based modeling study
Background Early detection through breast cancer screening significantly enhances survival rates and reduces mortality. However, financial constraints in low- and middle-income cou...
Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial
Background Frailty in older adults is on the rise with the rapid aging population. Frailty is dynamic and proven to be reversible or treatable. Evidence regarding the clinical effe...
Extended thromboprophylaxis after hip fracture surgery: Real-world evidence of direct oral anticoagulants versus low molecular weight heparin of unfractionated heparin
Background Hip fracture surgery carries the highest postoperative risk of venous thromboembolism (VTE) among surgical populations. Guidelines recommend low molecular weight heparin...
How digital infrastructure supports emerging forms of urban digital tourism in China
China’s ongoing digital transformation, supported by proactive government policies, is fundamentally reshaping urban tourism through strategic development of digital infrastructure. This study employs...
Adolescent pregnancy and early gestation depressive symptoms in rural Bangladesh: Is there an association?
Background/objective Pregnancy during adolescence continues to pose a major public health concern in low-and middle-income countries, including Bangladesh. Suffering from depressiv...
Supply chain stability: A study on the enabling effect of state-owned capital
Enhancing the resilience and security of industrial and supply chains is a key initiative to drive high-quality development of the real economy, yet the role of state-owned capital participation in th...
Impact of sugar-based baits on midgut microbiome composition in Aedes mosquitoes: Implications for vector control
The Aedes mosquitoes are responsible for the transmission of many severe diseases. Novel integrated vector management techniques like alginate hydrogel beads an...