PLoS ONE
Articles in this Issue
Establishment of a rabbit uterine cancer model using VX2 tumor fragments
Background Preclinical uterine cancer models using the rabbit VX2 system have been described in previous studies; however, they often involve complex procedures such as cell cultur...
Modeling the seasonal epidemic of human brucellosis in China: A comparative time series analysis
Background While time-series models have been applied to forecast brucellosis incidence in China, systematic comparisons of multiple models remain relatively limited. This study ai...
Understanding policy alignment in addressing hydrological hazards in the Niger Delta region, Nigeria
Combating climate change, flood risk, managing land use, and developmental change need cohesive policy action. Analysing policies is essential to assess whether there is a coherent approach where vari...
Temporal invariance of centrality correlations and hierarchical topology in evolving cross-shareholding networks in Japan (2001–2023)
In this study, we investigate the long-term evolution of the hierarchical structure and the stability of centrality correlations within Japan’s cross-shareholding networks. Using a 23-year dataset (20...
A dual-path framework for enhancing student engagement and learning outcomes in sports education: Integrating technology acceptance, self-regulation, and self-efficacy
The rapid adoption of mobile learning technologies in education has presented new opportunities and challenges for the innovative transformation of physical education. This study expands the Technolog...
Assessment of long COVID symptom burden in patients testing positive for SARS-CoV-2 at a nationwide retail pharmacy
Background Numerous grouping and scoring methodologies have been proposed to assess long COVID symptomatology. One approach is to use symptom count as a simple, quantifiable measur...
Examining women’s choice between home and institutional births: Insights from the Salud Mesoamérica Initiative (SMI)
This study examines women’s childbirth choices between home and institutional settings in the context of the Salud Mesoamérica Initiative, a results-based financing program focused on disadvantaged po...
Comparable performance of 3D and 2D anterior segment optical coherence tomography in predicting intraocular pressure reduction following cataract surgery
Purpose To develop predictive models using three-dimensional (3D) and conventional two-dimensional (2D) anterior-segment optical coherence tomography (AS-OCT) parameters for intrao...
Birth-related characteristics predict vision-related quality of life in adults: A population-based study
Background Individuals with an abnormal birth are at risk of having ophthalmic complications and visual impairment. The aim of this study was to understand the relationship between...
Synergistic antifungal activity of antiretrovirals with amphotericin B against Aspergillus species
Aspergillosis is a life-threatening fungal infection that primarily affects the lungs of immunocompromised individuals, including those living with human immunodeficiency virus (HIV), and is associate...
Inhibition of transient receptor potential vanilloid 1 (TRPV1) by a novel selective antagonist for anti-nociceptive effect on inflammatory pain without hyperthermia
Nowadays, chronic pain remains a major clinical challenge because of the unsatisfactory efficacy and nonnegligible side effects of current treatments. Pharmacological antagonists of the transient rece...
Residual metric learning with class-specific consistency for multiclass classification
Least squares regression (LSR) has been widely used in pattern recognition due to its concise form and ease of solution. However, inadequate exploration of inter-class margin and intra-class similarit...
Lived experiences of female second-cycle students with abnormal menstrual cycle in a selected municipality of Ghana: A phenomenological qualitative study
Background Menstruation can be accompanied by stressful experiences and one such experience is the abnormal menstrual cycle, which could include menstrual irregularity and painful...
Prevalence and risk factors of disordered eating risk among Yemeni medical students: A national multicenter cross-sectional study
Background Disordered eating behaviors represent an important mental health concern among medical students, who are exposed to substantial academic and psychological stressors. Dat...
Association between local food policy council coverage and longitudinal household food insufficiency during COVID-19, stratified by race, ethnicity, and income
Many local food policy councils (FPCs) worked to increase food access during the COVID-19 pandemic. Our objective was to determine whether households living in states with higher FPC coverage were les...
A standardised protocol for measuring farmland biodiversity outcomes across European Farmer Cluster landscapes
Farmland biodiversity has declined, with agricultural intensification cited as a major contributing factor. Therefore, monitoring farmland biodiversity in a consistent manner is a crucial aspect of de...
Sequoia affects Drosophila central nervous system development by regulating axonal extension and guidance
The development of the Drosophila melanogaster central nervous system (CNS) requires both determination of neuronal cell types and the subsequent establishment...
Surname match/mismatch revisited: It may no longer matter for partner choice
Kin recognition plays a crucial role in mating across various biological taxa, including bacteria, plants, and animals, to prevent inbreeding. Historically, surnames have been indicators of kinship in...
Provider costs of Antiretroviral therapy (ART) in Zimbabwe: The value of using time-driven activity based costing methods in a low resource setting
Although ART has transformed HIV into a manageable chronic condition, significant cost and logistical challenges persist, threatening progress toward the UNAIDS 95-95-95 targets. Budget allocation to...
The path to growth resilience: A serial mediation model linking temporal coherence to goal clarity and cognitive curiosity
Fostering growth resilience is critical for college students to succeed and develop amidst academic and social environment. Temporal coherence — a balanced integration of past, present, and future per...
Neurodevelopmental outcomes in preschool children with congenital heart defects: A case-control study using Ages & Stages Questionnaire
Objectives To investigate neurodevelopmental outcome in preschool children with a CHD (congenital heart defect) requiring surgery compared to healthy controls....
International Delphi consensus on acute kidney injury: Foundations for AI-driven digital twin development in critical care nephrology
Background Acute kidney injury (AKI) in critically ill patients is clinically complex and heterogeneous, limiting the development of structured simulation models. Digital twin appr...
Two-way FDI and corporate total factor productivity--moderating role of environmental information disclosure quality
This paper takes A-share Chinese listed companies from 2011 to 2021 as research samples and discusses the effects and potential moderating mechanisms of two-way FDI on corporate total factor productiv...
The coverage of maternal continuum-of-care and associated factors in the Lao People’s Democratic Republic: A population-based cross-sectional study
Maternal, newborn, and child health remains a global challenge, with continuum-of-care serving as a key strategy to improve health outcomes. This study aimed to examine the coverage of maternal contin...
Composite selection signal analysis: Uncovering candidate genes and quantitative trait loci in Indian sheep breeds
Selective pressures, both natural and artificial, have significantly influenced the genomic architecture of domesticated sheep. Understanding their underlying molecular mechanisms is critical for deve...