PLoS ONE
Articles in this Issue
Correction: Benznidazole therapy improves pressure overload and cardiac electrical profile in an experimental model of Angiotensin II infusion-induced hypertension: Mechanistic insights
Speech language pathologists’ attitudes on bilingual practices for children with autism in India: A qualitative study
The present study, aimed to investigate SLPs’ attitude regarding bilingual practices in children with autism. We conducted in-depth telephonic interviews on 13 SLPs working with autistic children in I...
Effectiveness of a five-component multimodal intervention on executive function in children with Autism spectrum disorder: A study protocol for a randomized controlled trial
Background Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social interaction, communication, and executive functions such as inhibitory control, cognitiv...
HiMSC and EV derived treatments increase Quality of Life and reduce amount of Knee Replacement Surgeries compared to current standard of care for knee osteoarthritis patients in The Netherlands
Objectives Current osteoarthritis treatments are designed to reduce pain and improve mobility instead of promoting the regeneration of cartilage. Cell-based therapies are being dev...
Sparse-selective quantization for real-time cyber threat detection in large-scale networks
We propose a sparse-selective quantization framework for real-time cyber threat detection in large-scale networks, which tackles the dual challenges of computational efficiency and detection accuracy....
Spatial proximity to national 5A tourist attractions and corporate environmental governance: Evidence from China
Tourism development is increasingly linked to both regional economic activity and environmental outcomes. However, empirical evidence remains limited on whether and through which channels proximity to...
Prevalence and correlates of low-level viremia and viral load non-suppression among adults on HIV treatment: Results from the Tanzania HIV Impact Survey, 2022–2023
Background While HIV viral load (VL) testing remained a critical approach for monitoring antiretroviral therapy (ART) effectiveness among people living with HIV (PLHIV), limited na...
Intelligent identification of rice leaf diseases via improved faster-RCNN with multi-feature scale fusion
Many Artificial Intelligence and Machine Learning technologies have been applied to detect rice diseases. These approaches are either unable to identify the diseases or have a slow recognition speed....
Plasma heme pool compartmentalization is linked to pathophysiology in Sickle Cell Disease
Heme toxicity plays a central role in the pathophysiology of Sickle Cell Disease (SCD), contributing to severe complications such as vaso-occlusion and acute chest syndrome. The continuous release of...
Study protocol to establish a prospective cohort for the study of phenotypic clusters, progression pathways, and outcomes of frailty and dependence: The CohorFES
Frailty has become a major challenge for health systems, but it also presents a window of opportunity to fight disability through preventive strategies focused on the detection and treatment of frailt...
Specific pre-injury migraine characteristics associated with worse concussion outcomes
Objectives We examined retrospectively recalled characteristics of pre-injury migraine and their association with retrospectively reported post-concussion outcomes....
Generating patient-specific computational models with point cloud data from human atrial electrophysiology studies
One in five patients diagnosed with atrial fibrillation die within a year after being diagnosed according to a prospective cohort study done in the United Kingdom, making this disease the focus of man...
APOE4 and doxorubicin impair inhibitory interneuron function and homeostatic regulation in the entorhinal cortex
APOE4 is a risk factor for several disease states associated with cognitive impairment, including Alzheimer’s disease and cancer-chemotherapy induced cognitive impairment. Using mo...
Prostate cancer tissue mapping and stratification using DRAQ5 and Eosin fluorescent labels integrated with AI classification and segmentation algorithms
Background Fluorescent microscopy using the DRAQ5 and Eosin probes has been shown in the literature to be capable of producing rapid tissue characterization through synthetic H&...
Retraction: AQP4-Dependent Water Transport Plays a Functional Role in Exercise-Induced Skeletal Muscle Adaptations
Covert audio recording of the clinical encounter to identify learning needs and exemplary performance in a pediatrics residency program
Background Physicians-in-training receive feedback based on assessment of their observed clinical skills in both the clinical setting and in simulations. These serve as proxy measu...
Content validity assessment and modification of the FACE-Q craniofacial module for retinoblastoma survivors
Purpose This study aimed to assess and modify the content of the FACE-Q Craniofacial Module, an appearance-based patient-reported outcome measure to address the lack of validated m...
Comparison of post-discharge mortality and medical expenditures in COVID-19 patients according to mechanical ventilation and extracorporeal membrane oxygenation use: The LIFE study
Outcomes related to health status and economic burden among patients who experienced critical COVID-19 remain insufficiently studied. We examined 180-day post-discharge mortality and total medical exp...
Two-period e-commerce platforms operation strategies considering the difference in product quality perception
The difference in consumer perceptions of product quality influences consumers’ propensity to purchase through various channels, thereby affecting the profit of e-commerce platforms and manufacturers....
Distribution patterns of aquatic birds in a high-Andean wetland in southeastern Peru: An approach based on environmental factors
High-Andean wetlands play a crucial role in avian biodiversity conservation, serving as ecological oases in arid mountain regions. These ecosystems face increasing anthropogenic pressures, yet researc...
Engagement of primary care physicians in medication decision-making for patients with multimorbidity in China: A cross-sectional study
Background Managing medications for patients with multimorbidity is complex and often leads to medication-related problems. Primary care physicians (PCPs) play a critical role in o...
Contribution of own food production to household dietary diversity and nutrient intake adequacy among refugee households in Palorinya, northwestern Uganda
Background Hunger and malnutrition are major global issues particularly in conflict and disaster-affected areas. Own food production has been considered as effective strategy to im...
Asthma patients are at increased risk for adverse events and reoperation following posterior lumbar fusion
Background Posterior lumbar fusion (PLF) is a common procedure for which patient factors are known to influence outcomes. Although asthma is comorbid for many PLF patients, it has...
A priming nudge targeting innovative farmers: A large-scale survey experiment
This article measures farmers’ innovativeness and the effectiveness of a priming nudge on their (stated) intention to adopt an innovation, namely the French “Low-carbon label” (LCL). The LCL is an inn...
On the ability of proglacial lake diatoms to reconstruct Antarctic past ozone changes
The depletion of Antarctic stratospheric ozone since the 1970s, and the resulting increase in UV radiation reaching the Earth’s surface, have posed a well-recognized threat to polar aquatic and terres...