PLoS ONE
Articles in this Issue
Effects of executive function training on balance and auditory-cognitive dual-task performance in adults with and without hearing loss
Background Multitasking, such as listening while balancing, relies on integrated processing in the sensory, cognitive, and motor systems; systems that often decline with age. Heari...
Pharmacophore- and QSAR-guided discovery of natural product inhibitors targeting dehydrosqualene synthase in Staphylococcus aureus
Dehydrosqualene synthase is a validated antibacterial target involved in Staphylococcus aureus staphyloxanthin biosynthesis, a key factor in oxidative stress re...
Paleolatitude.org 3.0: A calculator for paleoclimate and paleobiology studies based on a new global paleogeography model
Paleogeography, and particularly the paleolatitude, provides key context in the interpretation of paleoclimatic and paleobiological data but these fields are typically studied by scientists in differe...
Placental contractions in uncomplicated pregnancies
In 2020 we first described placental contractions; we have now undertaken a study to characterise these events and seek features that might automatically distinguish them from uterine contractions. We...
Integration of a neuronal RNAseq dataset with the draft Gryllus bimaculatus transcriptome refines gene predictions and highlights potential systematic response to injury
The cricket Gryllus bimaculatus presents a compelling model for investigating neuroplasticity due to its unusual capability of adult structural reorganization....
Multi-task gradient boosting with multi-modal molecular representations for simultaneous prediction of drug clearance and volume of distribution
Accurate prediction of pharmacokinetic parameters—particularly drug clearance (CL) and volume of distribution (VD)—is critical in early drug development, yet existing approaches largely treat these ph...
A feasibility study on the efficacy of a VR-based mindfulness intervention for dementia caregivers in the home environment: A pilot randomized control trial protocol
Background Dementia affects over 50 million people worldwide, with numbers projected to triple by 2050. Informal caregivers—predominantly family members—provide the majority of dai...
Artemether ameliorates type 1 diabetic liver injury alongside the associated defects in mitochondrial ultrastructure and central carbon metabolism
Type 1 diabetes mellitus (T1DM) is characterized by autoimmune-mediated destruction of pancreatic islet β-cells and the resultant absolute insulin deficiency, which leads to systemic metabolic dysregu...
Rotation-tolerant representations elucidate the time-course of high-level object processing
Despite the very different retinal images that result from different viewing conditions, humans have little difficulty recognising visual objects in varying circumstances. One source of variability is...
DualFusionNet: A fusion-based dual architecture for visual quality control on fabric surfaces
Zippers are essential in fashion and beyond. Found on jackets, shoes, and bags, they provide a versatile and practical opening and closing mechanism that seamlessly integrates into everyday use and sp...
Impact of moisturizing pretreatments on small reusable dental instruments cleanliness and mechanics
Background Effective cleaning of reusable dental instruments is crucial. Pre-cleaning moisturizing aims to prevent bioburden from drying; however, its comparative efficacy and impa...
Constitutive polysaccharide degradation and diet-dependent lipid metabolism reveal an adaptive feeding strategy in the pacific oyster Magallana gigas
Previous studies have identified several endogenous cellulases in the Pacific oyster Magallana gigas , indicating its potential to assimilate terrestrial carbon...
Coding for channels with intermittent feedback and its security analysis
The Schalkwijk-Kailath (SK) scheme for the AWGN channel with noise-free feedback is well-known since its coding complexity grows linearly with the coding blocklength, and it is capacity-achieving and...
A cross-sectional protocol for experimental tongue high-density surface electromyography to detect and classify radiation-associated hypoglossal neuropathy
Background Hypoglossal neuropathy is the most common lower cranial neuropathy detected as a delayed sequelae of Human Papillomavirus (HPV) -driven oropharyng...
Quality of care index and gender disparity ratio for stroke and its subtypes from the Global Burden of Disease Study 2021
Objectives This study aims to explore the quality of care index (QCI) for stroke, intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and ischemic stroke (IS) across nat...
Patterns and predictors of outcome monitoring amongst link workers: Learnings from the National Social Prescribing Link Worker Survey 2025
Background Effective outcome monitoring by Social Prescribing Link Workers (SPLWs) is critical for understanding the impact of social prescribing (SP) interventions. Despite nation...
A deep learning framework for remaining useful life prediction of turbofan engines with partial sensor failure
During long-term operation, turbofan engine sensors often suffer from partial damage or signal loss caused by complex flight environments, harsh mechanical vibrations, and thermal stresses. Such degra...
Layers to leaves: A suite of modular 3D printed hydroponics components for research and education
Hydroponics is a widely utilized technique to precisely control the plant growing environment and maximize productivity. In some cases, hydroponics systems can be expensive and require specialized exp...
Treatment experiences and preferences of British South Asians living with recurrent depression
Introduction Depression is one of the leading causes of disability and is a highly recurrent condition. Recurrent depression has been associated with risk of suicide and greater mo...
Which digital education approaches most effectively enhance clinical reasoning in undergraduate nursing students: Protocol for a Network Meta-analysis
Background Clinical reasoning is a core competency in nursing education, enabling students to make accurate and evidence-based clinical decisions. As digital-based learning expands...
Understanding development of Mainstream US English lexical stress using semi-naturalistic stimuli
Lexical stress—the emphasis placed on syllables within words—is a key feature of spoken language and an important marker for diagnosing speech and language disorders. However, current assessments of p...
Clinical manifestations of bed bug bites: A systematic review of case reports
Importance Clinical characterization of bed bug ( Cimex spp.) bite manifestations remains limited....
Leave the world(view) behind, but keep the words: The effect of conspiracism on writing
We investigate whether a stable predisposition to interpret events as the result of conspiracies—conspiracism—is associated with the spontaneous generation of conspiratorial content in writing when in...
Optimizing LSTM networks and feature selection algorithms using GEE data
Feature selection uncertainty and suboptimal model configuration in flood susceptibility mapping (FSM) are critical challenges for disaster risk reduction. This study introduces a novel integrated fra...
Influence of k-wire placement on impact mechanics and bone fracture in a rabbit model of cartilage injury
In vivo rabbit models that deliver mechanical impacts to knee cartilage are important for studying injury-induced osteoarthritis, but variability in impact characteristics limit the repeatability of t...