PLoS ONE
Articles in this Issue
Mapping qualitative research on motor imagery: A scoping review
Aim To examine the extent to which qualitative methods have been used in motor imagery research, and to characterize how these approaches have been applied....
Nonlinear thresholds in lipid-frailty interplay: Precision targets for severe airflow limitation in aging adults
Objective To explore the association between fat metabolism, frailty phenotype, and Severe Airflow Limitation（SAL） in middle-aged and elderly populations, identify non-linear thr...
Effects of hearing intervention on physical function: A secondary analysis of the ACHIEVE study
Objective We tested the effect of the hearing intervention vs. health education control (1:1 randomization) on 3-year physical function decline, a secondary analysis of the ACHIEVE...
Climate adaptation through farmer choice: Understanding preferences for rice varieties in coastal Bangladesh
The impact of environmental issues on agricultural livelihoods in Bangladesh's coastal regions—where traditional rice varieties are susceptible to salinity—is best illustrated by climate change-induce...
The application of stable carbon and nitrogen isotopes to assess the feeding ecology of long-finned pilot whales (Globicephala melas) in Scotland
Knowledge of the feeding habits of cetaceans is critical to the development of system-wide conservation strategies in marine ecosystems, yet dietary data are often lacking. To investigate the foraging...
Conservation and exploitation status of skate species (Batoidea: Rajidae) in the Balearic Islands, western Mediterranean
Batoids play key roles in marine ecosystems, yet their slow life history traits make them particularly vulnerable to overexploitation. The Balearic Islands remain a hotspot of batoid diversity, althou...
A comprehensive analysis of canonical biological pathways linking milk yield and quality traits to key fertility indicators in Murciano-Granadina dairy does
This study analyses relationships between milk yield, milk composition, and fertility in Murciano-Granadina dairy goats to test whether these associations reflect biological pathways underlying a prod...
Poldip2 deficiency attenuates lung disease severity in a mouse model of COVID-19
The lungs are the primary target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with the infection resulting in lung inflammation, pulmonary vascular leakage and diffuse alveolar dam...
Outcomes in acute pulmonary embolism and their association with adherence to international recommendations around COVID-19 pandemic-induced hospital-strain: The experience in a Mexican tertiary care center
Background Lack of adherence to international recommendations leads to worse outcomes. During the COVID-19 pandemic, the total number and proportion of hospitalized patients increa...
A predictive approach to integrating connectivity into landscape scale protected areas planning
It has been recognized that protecting at least 30% of terrestrial lands by 2030 (30x30) in systems of well-connected protected areas will be necessary for halting global biodiversity loss. While sign...
Seed priming-induced enhancement in seed germination, Seedling vigor, and productivity of foxtail millet (Setaria italica L.) in winter and summer seasons under Bangladesh conditions
Foxtail millet is a nutritionally rich and climate-resilient cereal crop; however, poor germination and weak early seedling growth often limit its productivity. This study evaluated the effects of see...
Whole transcriptome sequencing and ceRNA regulation network profiling of heat acclimation in protecting against heat stress injury in rat myocardium
Heat acclimation (HA) has emerged as a proven protective intervention to augment thermotolerance and mitigate heat stress (HS)-induced myocardial injury. Despite its clinical significance, the regulat...
Modeling chronic wasting disease transmission risk in mule deer related to habitat characteristics
Chronic wasting disease (CWD) is a prion disease of cervids that spreads to uninfected individuals through direct transmission (contact with infected individuals), vertical transmission (from mother t...
Safeguarding children and strengthening families through the application and utilization of family group decision making: A systematic review protocol
Children and families often face adversities that require whole-family interventions to promote well-being. Traditional child welfare models often demonstrate insufficient family involvement in decisi...
Melatonin and Coenzyme Q10 mitigate Senescence in Human Adipose-Derived Mesenchymal Stem Cells by Restoring Mitophagy and Mitochondrial Proteostasis
Mitochondrial quality control is a crucial factor governing self-renewal capacity, maintenance of metabolic balance, and cellular longevity in stem cells. Impaired mitophagy significantly contributes...
Bridging the research gap in conflict-affected countries: A multi-institutional study on medical students’ research involvement and barriers in Yemen
Background Undergraduate research engagement plays a pivotal role in promoting evidence-based medical practice, particularly in low-resource and conflict-affected settings such as...
Turning off inflammation naturally via dual antioxidant and anti-inflammatory actions of chestnut wood extract through PPARγ and NF-κB pathways
Background Inflammatory bowel disease (IBD) arises from a persistent imbalance between oxidative stress and immune homeostasis, driving tissue injury and chronic intestinal inflamm...
Qualitative analysis and numerical simulation of ABC fractional impulsive differential systems with implicit nonlinear terms and integral boundary conditions
This study presents a comprehensive qualitative analysis and numerical investigation of a novel class of fractional impulsive differential systems. The model incorporates the Atangana–Baleanu–Caputo (...
Oral step-down vs full-course intravenous antibiotic therapy for infective endocarditis: Protocol for a systematic review and meta-analysis
Background Infective endocarditis (IE) is a life-threatening condition traditionally managed with prolonged intravenous (IV) antibiotic therapy. However, sequential oral antibiotic...
Correction: Impact of dysfunctional parenting, affective temperaments, and stressful life events on the development of melancholic and non-melancholic depression: A path analysis study
A two-stage deep learning framework for lead instrument recognition in polyphonic music featuring Chinese instruments
Rapid advancement of deep learning methodologies has considerably progressed the domain of automatic music analysis; however, several challenges remain in adapting these approaches to the intricate an...
Spatial and temporal modeling of breast cancer mortality in Kansas: An R-INLA approach
Introduction Based on Breast Cancer Statistics, 2025, breast cancer is a leading cause of death among women in the United States. Geographic disparities and associated risk factors...
Effects of total intravenous anesthesia on postoperative quality of recovery and the levels of inflammatory factors in patients undergoing retroperitoneal endoscopic surgery in urology: Study protocol for a randomized, controlled trial
Introduction The utilisation of propofol-based total intravenous anesthesia has been demonstrated to reduce the incidence of postoperative nausea and vomiting, as well as postopera...
Catastrophic health care expenditure among older people with non-communicable diseases in 11 European Union Member States
Background Out-of-pocket payments by patients with chronic diseases can result in catastrophic expenditures. This study examines how chronic disease burden, measured by the presenc...
Two-dimensional ETTC–labeled longitudinal and lateral conflicts for interpretable real-time crash risk prediction in freeway interchange diverging areas
Current real-time crash prediction models (RTCPMs) for freeway diverging areas primarily rely on macroscopic traffic parameters, which inadequately capture how vehicle interactions escalate into crash...