PLoS ONE
Articles in this Issue
Phytochemicals from Astragalus zederbaueri as Acetylcholinesterase Inhibitors for Alzheimer’s Therapy
Alzheimer’s Disease (AD), the dominant form of dementia that evolves with age, involves several mechanisms by which it progresses. The cholinergic hypothesis proposes that the activity of Acetylcholin...
Genomic characterization of Comamonas kerstersii isolated from diarrheal patients in Bangladesh
This study marks the first identification and genomic characterization of Comamonas kerstersii isolates from diarrheal patients in Bangladesh. We carried out th...
Low ALDH1A1 expression in relation to nodal metastasis and survival in tongue squamous cell carcinoma
Background/Aims Multiple biomarkers have been proposed to identify cancer stem cells in tongue squamous cell carcinoma. This study evaluated ALDH1A1, an ALDH1 subtype implicated in...
Water-soluble gadolinium fullerenes Gd@C82-TEGs as a potential magnetic resonance imaging contrast agent
The water-soluble gadolinium fullerenes Gd@C 82 -TEGs nanoparticles as a novel magnetic resonance imaging (MRI) contrast agent were fabricated by the metal full...
Applying machine learning and natural language processing to patient safety event reports: Identifying patterns of cardiovascular diagnostic errors
Objective To explore the utility of natural language processing (NLP) and machine learning (ML) techniques to identify unsafe conditions leading to cardiovascular diagnostic errors...
Lightweight blockchain facilitated BIM data management for smart city operation and maintenance
Building Information Modelling (BIM) project operation and maintenance information management in smart cities currently faces challenges like data redundancy, a large number of management and maintena...
In foreign pastures: Livestock mobility at Hazor and the permeability of Iron Age geopolitical borders in the Southern Levant
Southern Levantine societies during the Iron Age II (10 th –8 th centuries BCE) witnessed the formation of competing ter...
Endometriosis treatment pathways in the largest private health insurance in Brazil: A real-world data study
Introduction Endometriosis is a prevalent chronic gynecological condition affecting women of reproductive age, characterized by ectopic endometrial-like tissue growth. Despite its...
The impact of water management and nitrification inhibitors on methane emissions from paddy soil
Methane (CH₄) is a potent greenhouse gas, and rice paddies are a major source of agricultural CH₄ emissions. Water management and nitrification inhibitors can significantly affect CH...
Network pharmacology and integrative bioinformatics analyses identify PDE1A as a key target of pirfenidone in idiopathic pulmonary fibrosis
Pirfenidone, an antifibrotic agent, has been shown to be effective in the treatment of idiopathic pulmonary fibrosis (IPF). However, the exact mechanism of action and clinical efficacy require further...
Topology-aware design of spiking neural networks via modular graph architectures
Spiking Neural Networks (SNNs) offer a biologically plausible and energy-efficient alternative to traditional artificial neural networks (ANNs), yet their design remains constrained by limited archite...
Prevalence and risk factors for AMS: A systematic review and meta-analysis
Background Acute Mountain Sickness (AMS) is a high-altitude-specific condition with variable prevalence and poorly defined risk factors. Despite growing global exposure to high-alt...
Maternal sleep quality during pregnancy and neonatal outcomes: A study from Riyadh, Saudi Arabia
Background Poor sleep quality during pregnancy has been increasingly associated with adverse neonatal outcomes and heightened maternal psychological distress. However, evidence fro...
Large Scale Food Fortification (LSFF) in East, Central, and Southern Africa: Gaps, opportunities and the way forward
Background Micronutrient deficiencies affect 2 billion people globally, especially in sub-Saharan Africa, where iron, vitamin A, iodine, zinc, calcium, selenium, folate, and vitami...
Association between hypertension and impaired lung function among adults: A systematic review and meta-analysis
Background Impaired lung function and hypertension are both significant global public health concerns, and their potential association has recently drawn considerable interest. Thi...
Environmental health literacy competencies and teaching methods for students and health professionals in Primary Health Care: A scoping review
Environmental determinants play an increasingly important role in shaping population health, highlighting Environmental Health Literacy (EHL) as a critical competency for Primary Health Care (PHC). De...
Association of visceral fat and plasmacytoid dendritic cell-derived interferon alpha with SARS-CoV-2 infection
Type I interferon (IFN-I: IFNα/β) production by plasmacytoid dendritic cells (pDCs) is critical for controlling viral infections. Visceral fat obesity is associated with severe outcomes in viral infec...
Risk factors for spontaneous abortion following hepatitis E vaccination during and shortly before pregnancy: Further analysis from a cluster-randomized trial
Background A recent randomized trial of Hepatitis E Vaccine (HEV239) found an elevated risk of spontaneous abortion (SAB) in women given HEV239 during or within ninety days before...
Spatiotemporal dynamics and forecasting of public attention to entrepreneurship education: An entropy-based modeling approach
Entrepreneurship education is increasingly important with the development of digital economy and post-pandemic. However, the distribution of public attention to entrepreneurship education (PAEE) remai...
Unsupervised industrial image defect detection based on autoencoder and GANs
In the process of intelligentization in modern manufacturing, especially in industrial fields such as automobile manufacturing, semiconductor production, and electronic product assembly, product quali...
Development and validation of the belonging at work scale: Association with mistreatment and leaves
This research developed the Belonging at Work Scale (BWS), a 7-item, unidimensional measure of work group inclusion focusing specifically on belongingness. Collecting data from 2 Canadian employee sam...
Weaving the future: Maturity and key factors in women’s cultural entrepreneurship in Colombia’s artisan sector
Women-led cultural enterprises in Colombia have emerged as a strategic opportunity to strengthen the cultural economy, support heritage tourism, and foster inclusive territorial development. This stud...
The impact of high fat diet on global protein abundance and fractional synthetic rate in liver and mammary gland of peak lactation ICR mice
Maternal metabolic environment creates the developmental environment for offspring. Previous studies demonstrated high fat (HF) diet increased neonate growth rate during lactation, which related to in...
A common network of residue-residue contacts underlies interactions between peptides and HLA class II complex
The formation of a stable antigenic peptide-HLA II (p-HLA class II) complex is a critical early step in the adaptive immune response. In this work, we identify the residue-residue contacts that ‘ancho...
Assessing the influence of diverse skills on employability outcomes for IT undergraduates
Rapid technological advancements have reshaped the global job market, emphasizing the importance of specialized competencies such as user interface (UI) and user experience (UX) design, alongside tech...