PLoS ONE
Articles in this Issue
Microbial and small zooplankton communities predict density of baleen whales in the southern California Current Ecosystem
Understanding the distribution and abundance of marine mammals is important for assessing population dynamics and evaluating the impacts of human activities on these species. Here, we assessed the cap...
Distinct psychological profiles and responsiveness to a brief intervention in workers with high versus low intensity emotional labor: an observational study
Emotional labor refers to the process by which employees regulate and manage their emotions as part of their job requirements. This observational study examined distinct psychological profiles and dif...
Machine learning-based unified models for predicting drug clearance from pharmacokinetic animal and study design variables
Clearance (CL) is a primary pharmacokinetic (PK) parameter crucial to determine how quickly a drug is eliminated from the body, which guides the appropriate dosing interval to maintain a consistent co...
PDE and agent based simulation approaches to Ischemic Dermal Wound Closure
Ischemic dermal wounds present a significant medical challenge, especially in the case where the wound does not close in an expected time, typically 30 days. We developed two very different mathematic...
Generation Z involvement, cultural identity, and purchase intention in the homestay context: Evidence from tea-culture homestays
This study examines how Generation Z involvement influences purchase intention for tea-culture homestays and whether cultural identity mediates this relationship. The attention of generation Z consume...
From fork to fatherhood: Unveiling the link between dietary pattern indices and biochemical parameters of semen
A cross-sectional design was employed to elucidate the interplay of dietary pattern index scores and seminal and serum biochemical parameters in men presenting to our infertility clinics. Ninety men w...
Race, nationality, and partisanship shape U.S. public support for climate disaster aid: Evidence from two survey experiments
We examine how race, nationality, and political partisanship influence U.S. public support for climate-related disaster aid. Using two preregistered survey experiments (N = 7,511), we varied the race...
Enhanced tourist flow forecasting in Aosta Valley: A novel ensemble AI framework with adaptive temporal dynamics
Despite significant advances in tourism forecasting methods, current approaches suffer from critical limitations including static ensemble weighting mechanisms that fail to adapt to changing environme...
Node properties of biomarkers within the protein–protein interaction network derived from breast cancer-associated genes
Analyzing the network properties of cancer biomarkers within protein–protein interaction (PPI) networks is valuable for discovering novel biomarker candidates. Therefore, we constructed PPI networks u...
Response of water and salt accumulation in vadose zone to groundwater level changes in coastal saline soils using HYDRUS-1D model
Purpose Coastal saline soils are highly vulnerable to salinization, posing a major threat to sustainable agriculture. This study investigates how fluctuations in groundwater depth...
Predicting corporate management performance using AI: Incorporating CEO strategy insights from sustainable management reports
This study proposes an AI-based model to predict corporate management performance by combining financial data with strategic information extracted from CEO messages in sustainability reports. Using a...
Echo chambers can emerge without algorithmic personalization or a preference for homogeneity
Online ideological segregation—often described as “echo chambers”—is commonly attributed to algorithmic personalization (“filter bubbles”) or users’ preferences for like-minded environments. We propos...
Individual and ensemble perception in naturalistic scenes: Effects of context and presentation time
In many everyday tasks, we must identify both single objects, as well as object ensembles. Our understanding of the mechanisms behind individual and ensemble perception comes mainly from studies condu...
Rationale and design of a multicenter, prospective, diagnostic clinical study: A study protocol for evaluating the diagnostic validation of deep learning-based noninvasive CT-FFR for in-stent restenosis
Introduction Currently, there are many diagnostic strategies for in-stent restenosis (ISR) used clinically, including invasive coronary angiography (ICA), coronary computed tomogra...
Surface anticoagulation of mechanical heart valves using electrically induced biomimetic glycocalyx: An in-vitro study to assess hemocompatibility and optimal voltage
Mechanical heart valves (MHVs) remain the most durable option for valve replacement, but they are highly thrombogenic and therefore necessitate life-long anticoagulation. We designed a novel MHV assem...
Multilevel exposure to adversity across the life course and biological implications among urban postpartum women: A cohort study protocol
Maternal mortality and morbidity in the United States remain substantially higher than in other high-income countries. Evidence suggests that exposure to chronic stress and social and environmental ad...
Nasal steroids, irrigation, oral antibiotics, and subgroup targeting for effective management of acute sinusitis (NOSES): Protocol for a comparative effectiveness randomized controlled trial
Introduction Acute rhinosinusitis (ARS) affects approximately 15% of adults annually. It accounts for nearly 30 million outpatient visits and one in five antibiotic prescriptions,...
Dutasteride treatment and its effect on standardized uptake values in prostate-specific membrane antigen-PET imaging: A pilot study
Background Prostate-specific membrane antigen (PSMA)-based imaging has become an increasingly important diagnostic tool in prostate cancer, though limited by...
Dynamic platelet profiles in the emergency department and their predictive value for 28-day all-cause mortality in septic patients
Background Sepsis is a significant cause of global mortality and most frequently first presents in the emergency department. Dynamic platelet changes play a key pathophysiological...
Intelligent diagnosis of major depressive disorder with edge convolution and contrastive learning
Based on functional connectivity (FC) matrices derived from resting-state functional magnetic resonance imaging (rs-fMRI) data, graph neural networks (GNNs), as an advanced deep learning technique, ha...
EGFR-targeted affibody–polyIC polyplex kills EGFR-overexpressing cancer cells without activating the EGFR
The epidermal growth factor receptor (EGFR) is aberrantly activated in many human epithelial cancers. This report presents the preparation, purification, and the anti-cancer potency of an anti-EGFR af...
“If I can get my work done, I’m not addicted to my phone”: Investigating smartphone use among language students
The study of smartphone addiction among college students reveals significant gaps, particularly in understanding its impact on specific academic groups, such as language learners, whose unique relianc...
Editorial Note: Investigating water movements around a shallow shipwreck in Big Tub Harbour of Lake Huron: Implications for managing and preserving underwater shipwrecks
Retraction: Therapeutic Potential of Date Palm Pollen for Testicular Dysfunction Induced by Thyroid Disorders in Male Rats
Industrial-grade nitrogen sources modulate CaCO3 polymorphs and strength in MICP-cemented sand: A structure–property study
Microbially induced carbonate precipitation (MICP) is promising for soil stabilization. However, its large-scale application is hindered by the cost of laboratory-grade yeast extract (YE), which often...