PLoS ONE
Articles in this Issue
Concurrent circulation of avian influenza viruses H5N1 and H9N2 enhances the genetic evolution of reassortant viruses in Egyptian poultry populations
The co-circulation of the recently emerged H5N1 clade 2.3.4.4b and the endemic H9N2 avian influenza viruses (AIV) in poultry farms has led to significant economic losses and increased the likelihood o...
Molecular signature evolution of coal-derived dissolved organic matter under geothermal conditions: FT-ICR MS and machine learning
The accurate identification of water sources and tracing of inrush pathways in deep coal mines remain challenging, as elevated geothermal temperatures can alter the molecular fingerprints of coal-deri...
Symptom presentation, perceived causes, and help-seeking practices among adults receiving depression or anxiety care in Nepal: A qualitative study
Depression and anxiety are prevalent worldwide, yet fewer than 20% of individuals in low- and middle-income countries receive appropriate care. Cultural norms play a significant role in how symptoms a...
Day-night variations in sleep and locomotor activity in lambs during the first 72 hours after birth and following the onset of rumination
The sleep-wake and rest-activity profiles of many species undergoes changes during the development. In ruminants, the onset of rumination-related digestive function is contingent on the attainment of...
Astragaloside IV attenuates high-glucose-Induced peritoneal fibrosis via modulation of the ENKUR/PI3K/Akt signalling pathway
This study aimed to explore the mechanisms by which Astragaloside IV (AS-IV), a major bioactive component of Astragalus membranaceus , mitigates high-glucose-in...
Smartphone-based accurate pothole depth estimation using monocular RGB and LiDAR-guided deep learning
The maintenance of the road infrastructure is vital to ensure public safety and the efficiency of transportation, but the unpredictable and widespread occurrence of potholes often hinders continuous m...
A novel positive selection system for plant transformation based on microbial biuret hydrolase and biuret
Conventional selectable marker genes (SMGs) in plant transformation, such as those conferring antibiotic resistance, raise biosafety concerns due to their permanent genomic integration. Alternative sy...
Association between vitamin D status and circulating myokines (irisin, myostatin, and myonectin) in children: A cross-sectional study
Background Vitamin D is a pleiotropic hormone with regulatory functions that extend beyond bone and mineral metabolism to include skeletal muscle physiology. Skeletal muscle acts a...
Secure near-lossless medical image compression and encryption with image-specific post-quantum key management and blockchain-based verification
Secure image transfer is a critical requirement in telemedicine and Picture Archiving and Communication Systems (PACS), where diagnostic integrity and patient confidentiality must be simultaneously en...
An exploratory dosimetric and treatment-time analysis of tangent-arc and continuous semi-arc VMAT in deep inspiration breath-hold radiotherapy for stage I left-sided breast cancer
Background The use of the deep inspiration breath-hold (DIBH) technique reduces cardiac and lung radiation exposure during left breast cancer radiotherapy. However, the optimal bea...
A modular deep learning architecture for interpretable disease prediction across tabular clinical and biometric datasets
Accurate disease prediction using clinical datasets is essential for improving early diagnosis and clinical decision-support systems; however, many existing deep learning approaches are disease-specif...
Copper causes reduced nitrogen fixation but does not accumulate in the nodules of the legume Lotus japonicus
Copper can be a soil contaminant at concentrations that are toxic to plants, particularly because of copper-induced oxidative stress. The legume-rhizobia partnership that allows for biological nitroge...
The ketogenic diet alleviates autoimmune thyroiditis caused by Th17/Treg imbalance by inhibiting the HMGB1/NLRP3 signaling pathway
Background Autoimmune thyroiditis (AIT), caused by immune-mediated thyroid dysfunction, lacks effective dietary interventions. This study investigates the therapeutic potential of...
Effects of pica practice on oral bacteriome and mycobiome profiles among pregnant women: A comparative study
Introduction Pica, the excessive craving and consumption of non-food substances such as clay, and ice, is common among pregnant women but may pose risks for oral and systemic infec...
Differences in the long-term course of post-COVID-19 symptoms in adults and children across epidemic periods: A retrospective cohort study in Japan, 2020–2024
Background The prevalence of post-COVID-19 symptoms has been reported to decline since the Omicron variant became predominant. However, differences in their long-term course across...
A study on turbulence characteristics of a rectangular three-dimensional wall jet in a confined space using particle image velocimetry
A three-dimensional wall jet in a confined space is a ubiquitous flow occurrence in important engineering domains. Previous studies have not fully explained its turbulence characteristics. In this pap...
Significance of RGS13 expression in lupus B cells
Objectives B cells play important roles in systemic lupus erythematosus (SLE) pathogenesis. In this study, we explored the proteins preferentially expressed in SLE B cells, especia...
Socioeconomic inequalities and the COVID-19 pandemic in France: Territorial analyzes based on epidemic wave and metropolitan area
Background Previous studies have highlighted the relationship between socioeconomic inequalities and the general population’s risk of contracting or dying from COVID-19 during the...
A snapshot of HIV-1 genetic diversity in Dominican Republic in 2024: Predominance of the BCar lineage and first description of a CRF02-AG isolate
Although a decrease in the incidence of HIV-1 infection has been observed in the Caribbean, the prevalence of this viral infection is still around 1% in Dominican Republic. It has been shown that the...
Sleep, sedentary behavior, and physical activity: A compositional data analysis of 24-hour movement behaviors and executive function in preschool children
Objective This study aims to examine the relationship between 24-h movement behaviors and executive function in preschool children....
Childhood cancer survivors’ struggle for social integration after treatment a mixed-methods exploration of activity and participation
Purpose Childhood cancer presents lasting challenges beyond primary treatment, affecting multiple aspects of daily life. This mixed-methods study examines the impact of childhood c...
Effect of screen time and outdoor activities on myopia progression
Objective To assess the impact of screen time and outdoor activities on myopia progression in Lebanese children and to compare age groups....
Swiss public attitudes to human cryopreservation
Cryopreservation, or cryonics, is an experimental procedure that preserves individuals at cryogenic temperatures after legal death in the hope of future revival. Although Switzerland hosts the Schenge...
Effects of boron and nitrogen doping on the electronic properties of graphene-based heterostructures with two-dimensional semiconducting materials
Based on first-principles density functional theory (DFT) calculations , heterostructures composed of graphene and two-dimensional semiconducting materials exhi...
Comparative metabolic profiling, enzyme inhibitory activities, and in-silico analysis of the hexane extract and the hydrodistilled oil of Boswellia serrata
Frankincense ( Boswellia spp.) oleogum resin is a valuable natural source of bioactive phytoconstituents with diverse therapeutic potential. In this study, the...