PLoS ONE
Articles in this Issue
Comprehensive feature evaluation of the main facades of Catholic churches in Sichuan-Chongqing region based on semantic difference method, 1840–1949
The existing Catholic churches constructed in the Sichuan-Chongqing region between 1840 and 1949, as precious carriers of Sino-Western cultural integration, have been listed in the cultural heritage p...
Gender-specific sociodemographic and lifestyle factors associated with frailty status among Korean older adults
This study aimed to identify gender-specific sociodemographic and lifestyle factors associated with frailty among Korean older adults. We conducted a cross-sectional analysis using data from the 2014–...
Psychometric evaluation of the ethical caring competency scale among Iranian Nurses: A methodological study
Background Nurses face complex ethical challenges across diverse healthcare settings, making ethical caring competency essential to professional practice. Given that Iranian nurses...
Cost of fruiting, size regulation, and senescence in a long-lived geophyte
Grown in a transplant garden that provides field conditions but prevents predation by pocket gophers, plants of Erythronium grandiflorum (Liliaceae) have been e...
Targeted analysis of KRAS and CREBBP mutations uncovers a potential population-specific signature in thai patients with liver fluke-associated cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy with limited therapeutic options and a poor prognosis. Opisthorchis viverrini (OV) infection...
Age-related upregulation of p16 expression in mouse ovarian somatic cells correlated with reproductive function decline p16 expression and ovarian aging in mice
Female reproductive aging is a major clinical challenge associated with declining fertility and increased pregnancy complications. The urgent clinical need for developing reliable biomarkers to evalua...
Morphological, molecular, and pathological characterization of didymozoid trematode infection in the nasal cavity of orange-spotted grouper (Epinephelus coioides) from Arabian Gulf waters
Background Didymozoid trematodes represent poorly understood parasites of marine fish worldwide, with significant knowledge gaps in the Arabian Gulf region. The taxonomic identific...
Using fractal model and factor analysis for FACA modeling and its application in deep mineral prediction
Objective This paper designs a FACA model for deep mineral prediction in actual mining areas. Method T...
Seeding food security: Overcoming barriers to quality potato seed adoption among smallholders in Kenya
Access to quality seed potatoes is essential for boosting productivity and food security among smallholder farmers. However, the adoption and use of these seeds remain low in Kenya, thus constraining...
Chinmo affects developmental timing and patterning during cockroach embryogenesis
The transcription factor Chinmo (short for Chronologically Inappropriate Morphogenesis) is a key regulator of developmental timing and metamorphosis in insects, where it represses metamorphosis-relate...
The wild, wild west of plasmids: First insights into comparative genomics of Borrelia burgdorferi sensu lato
Lyme borreliosis is caused by species of the Borrelia burgdorferi sensu lato complex. Genospecies vary in human pathogenicity, reservoir host and tick vector ad...
Design and experimental validation of multi-section directional coupler with arbitrary coupling and high directivity for sub-6 GHz UWB applications
This work presents a geometrically simple topology for developing an ultra-wideband directional coupler with improved coupling and directivity. A short-ended coupled-line structure is used to achieve...
Cardiometabolic indices as predictors of clinical outcomes in palliative care patients
Background Multiple cardiometabolic indices have been proposed for prognostic assessment, yet their comparative performance in palliative care remains unclear. The triglyceride-glu...
Evaluation of an automated reader for disc diffusion antimicrobial susceptibility testing in a routine microbiology laboratory
Antimicrobial susceptibility testing (AST) is essential for determining the in vitro activity of antimicrobial agents against specific microorganisms. Reliable...
DeepDRP: Dose-response predictions of drug pairs using deep learning based on data-driven feature representation and dose-response curve characteristics
Combination therapies have become a cornerstone of modern medicine, offering improved treatment outcomes and reduced side effects compared to monotherapies. However, the efficacy and safety of drug co...
Hybrid Bacterial Colony Optimization and Particle Swarm Optimization for load balancing in fog computing
Fog computing minimizes latency and bandwidth consumption by processing data near the source, but it has the challenge of workload balancing across the dynamic and resource limited fog nodes. Uneven t...
Outage performance of UAV-NOMA networks over rician faded channel with hardware impairments, channel estimation error, and SIC imperfection
The escalating demand for enhanced coverage and high data rates in wireless networks is driving the adoption of advanced technologies like unmanned aerial vehicles (UAVs). Integrating UAVs with non-or...
Perceptual learning mechanisms with single-stimulus exposure
The present manuscript briefly reviews associative and non-associative theories of perceptual learning and presents two experiments (1a and 1b) examining the extent to which retrospective revaluation...
Variants in the DNAH11 gene responsible for primary ciliary dyskinesia or probably atypical primary ciliary dyskinesia presenting left-right asymmetry disorder
Primary ciliary dyskinesia (PCD) is a rare multi-system cilia-related disorder, and approximately 50% of individuals with PCD exhibit left-right asymmetry disorder. The dynein axonemal heavy chain 11...
Optimal seamline detection for SAR image mosaicking guided by superpixel segmentation and region merging
Large-scale studies and applications of SAR images require the mosaicking of multiple scenes. However, geometric misregistration and radiometric inconsistencies among adjacent images often lead to poo...
Feasibility, acceptability, and fidelity evaluation of a contextualised physical activity and diet intervention for hypertension control in rural South African adults
Despite the known benefits of physical activity and diet modifications for hypertension control, adults in rural South African settings still have high levels of uncontrolled hypertension. This paper...
A pumpless liver-adipose model for studying metabolic dysfunction and drug responses
Metabolic dysfunction is a primary driver of chronic diseases, such as obesity and type 2 diabetes. Developing in vitro models allows to understand metabolic me...
Systematic evaluation of the DeepSeek large language model for clinical diagnostic reasoning
Background Artificial intelligence (AI) is undergoing an era of transformative advancement, particularly through the emergence of Transformer-based large language models (LLMs). Wh...
Machine learning-based model for predicting recanalization in isolated distal deep vein thrombosis and analysis of predictors
Background Isolated distal deep vein thrombosis (IDDVT) is common, yet tools for predicting poor recanalization remain limited. We aimed to develop and compare machine learning mod...
Women’s Empowerment Metric for National Statistical Systems (WEMNS): Development and psychometric assessment of a face-to-face survey module
Data to monitor progress towards gender-related Sustainable Development Goals (SDGs) remain limited. A comprehensive, concise set of metrics is needed for routine national data collection to monitor p...