PLoS ONE
Articles in this Issue
Circular economy approach to eggshell waste utilisation: Insoluble protein extraction and CaCO3 upcycling for carbonated hydroxyapatite (cHAP)-based fire-resistant wood
Transitioning to a resource-efficient and sustainable circular economy is vital for tackling climate- and environmental-related challenges. This study demonstrates a closed-loop strategy for upcycling...
PEC-CDC: A prediction error-based calibration framework for robust unsupervised deep clustering
While deep clustering has made significant strides, the inherent overconfidence of Softmax-based calibration remains a critical bottleneck. Even dedicated frameworks like Calibrated Deep Clustering (C...
Erythropoietin, transfusions, and outcomes of retinopathy of prematurity and brain injury in extremely preterm infants: A post hoc analysis of the Preterm Erythropoietin Neuroprotection Trial (PENUT)
Background Erythropoietin is perceived as both a neuroprotectant and a biomarker for hypoxic stress. Objective...
Association between depression and cardiometabolic multimorbidity: A protocol for a systematic review and meta-analysis
Introduction Cardio metabolic multimorbidity (CMM) is increasingly prevalent and associated with substantial morbidity and mortality, yet the role of depression in the clustering o...
Editorial Note: The impact of COVID-19 on opioid toxicity deaths for people who experience incarceration compared to the general population in Ontario: A whole population data linkage study
Investigation of correlation between cholesterol intake, apolipoprotein B and Parkinson’s disease related genes in guinea pigs feeding a high-fat diet containing cholesterol
Apolipoprotein B (Apo B), which is involved in the transport of cholesterol, is thought to be associated with neurodegenerative diseases such as Parkinson’s disease in addition to atherosclerosis and...
Childhood to Adult Neurodevelopment in Gene-Expanded Huntington’s Disease (ChANGE-HD): A prospective longitudinal neurodevelopmental study of Huntington’s disease
Although adult Huntington’s disease (HD) studies have significantly advanced our understanding of the course of degeneration, they may underrepresent critical neurodevelopmental aspects of the disease...
Large-deformation consolidation analysis of foundations based on the elliptical cylinder equivalent drainage plate theory
Building upon the elliptical cylinder equivalence model, this study integrates the nonlinear variations in soil compressibility and permeability, together with the attenuation behavior of vacuum press...
Correction: Geometric and singularities insights of swept surfaces via the Bishop frame in Euclidean 3-Space
Bioinformatics analysis of pyroptosis-related differentially expressed genes in sepsis and diabetes mellitus
Sepsis and diabetes mellitus (DM) are major global health issues with high morbidity and mortality, necessitating new molecular insights for improved treatments. In this study, pyroptosis-related diff...
Social media activities to enhance the visibility of long-term invasive ventilation: A content and visibility analysis from the PRiVENT study
Background Despite the increasing number of patients receiving long-term invasive mechanical ventilation (IMV) and the social importance of this issue, it is largely neglected in t...
A tale of SARS-CoV-2 genomic surveillance in Mali: Variants introductions and transmission dynamics
Despite the global scale of SARS-CoV-2 genomic surveillance, data from West Africa are limited. In Mali 33,197 confirmed cases and 743 deaths (case fatality ratio: 2.23%) were recorded between March 2...
Visualizing youth sports specialization and injury risk: A novel application of swimmer plots
Background As research on sport participation in youth and the impact of sport specialization on injury increases, the value of a standardization of data variables and an easily in...
Genomic characterization of multidrug-resistant Escherichia coli isolated from gills of Labeo rohita: Insight into resistome, virulence and pathogenicity
Antibiotic resistance in aquaculture settings is an emerging issue that threatens animal and human health. In this work, a multidrug-resistant (MDR) Escherichia coli...
Efficacy of adjunctive antibiotics compared to non-antibiotic therapies following mechanical debridement for peri-implantitis: A systematic review and meta-analysis of randomized controlled trials
Objective To evaluate the efficacy of antibiotic therapy as an adjunct to mechanical debridement in peri-implantitis. Meth...
Digital storytelling across the life course: Protocol for a theory-based analysis
Background Digital storytelling (DST) combines first-person narratives with images, sound, and video to convey health experiences, empower under-represented voices, and foster empa...
Spatial distribution of diphtheria cases during the 2022/2023 outbreak in Kano State, Northern Nigeria
After decades of control, a nationwide diphtheria outbreak occurred in Nigeria in 2022, with approximately 75% of confirmed cases reported in Kano state, Nigeria. We assessed the spatial distribution...
Brief intervention, lasting impact: One-year outcomes of the Bergen 4-day treatment for OCD in Germany
Background Obsessive–compulsive disorder (OCD) is a prevalent and highly disabling mental disorder. Worldwide, it is associated with substantial individual suffering and long-term...
Direct-acting antiviral therapy is associated with a reduced risk of selected immune-mediated inflammatory diseases in chronic hepatitis C infection: A real-world cohort study
Background Chronic hepatitis C virus (HCV) infection is associated with immune dysregulation and an increased risk of immune-mediated inflammatory diseases (IMIDs). While direct-ac...
Few-shot skin lesion classification with Adaptive Multi-Scale Convolutional Attention Network
Computer-aided diagnosis of skin lesions faces core challenges, including scale diversity, blurred boundaries, intra-class morphological variations, and sparse data. Existing methods often rely on fix...
Fixed BMI eligibility criteria for GLP-1 receptor agonist trials and estimated trial-eligible proportions in Asian and non-Asian populations: A cross-sectional analysis
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are globally developed for metabolic diseases, yet clinical trials have underrepresented Asian populations who develop metabolic complications at...
Multiobjective dynamic resource allocation in cloud computing using Harris Hawk Optimization Algorithm (MDLB-HHO)
To increase cloud computing utilization and performance, efficient load balancing and resource distribution techniques are essential. Dynamic load balancing and resource allocation in cloud systems is...
A compact wideband Wilkinson Power Divider topology for arbitrary N-Way outputs
This work presents a compact Wilkinson power divider (WPD) topology capable of realizing arbitrary 1 × N equal power divisions without requiring crossovers or...
A polymorphism and expression levels of SCD and their relationships to production traits in a Japanese farmed emu population
The emu is a novel poultry species producing meat, eggs, and fat. In particular, emu oil derived from the fat is considered the most important product of the emu owing to its anti-inflammatory and ant...
Computational evaluation of fluid flow influencing geometrical parameters of cyclone separator for Cement Kiln
Cyclone separators are integral to cement kiln operations, serving as key devices for mitigating air pollution and reducing particulate matter. Computational Fluid Dynamics (CFD) simulations enable vi...