PLoS ONE
Articles in this Issue
A superior tool for predicting sepsis in SAH patients: The nomogram outperforms SOFA score
Objective This study aimed to develop and validate a nomogram to predict the risk of sepsis in non-traumatic subarachnoid hemorrhage (SAH) patients using data from the MIMIC-IV database. Methods A t...
Muscular TOR knockdown and endurance exercise ameliorate high salt and age-related skeletal muscle degradation by activating the MTOR-mediated pathway
The target of rapamycin(TOR)gene is closely related to metabolism and cellular aging, but it is unclear whether the TOR pathways mediate endurance exercise against the accelerated aging of skeletal mu...
The PSO-IFAH optimization algorithm for transient electromagnetic inversion
As a non-contact method, the transient electromagnetic (TEM) method has the characteristics of high efficiency, small impact of device, no limitation of site range, and high resolution, and is a hot t...
Exploring the association between sleep quality, internet addiction, and related factors among adolescents in Dakshinkali Municipality, Nepal
Background Poor sleep quality and internet addiction are significant issues affecting adolescents globally, and Nepal is no exception. Several studies have independently assessed the prevalence and as...
Knowledge, attitude, and practice toward coronary heart disease secondary prevention among coronary heart disease patients in Shanghai, China
Background This study aimed to investigate knowledge, attitude, and practice (KAP) toward coronary heart disease (CHD) secondary prevention among CHD patients. Methods This web-based cross-sectional...
Automated extracellular volume fraction measurement for diagnosis and prognostication in patients with light-chain cardiac amyloidosis
Aims T1 mapping on cardiac magnetic resonance (CMR) imaging is useful for diagnosis and prognostication in patients with light-chain cardiac amyloidosis (AL-CA). We conducted this study to evaluate th...
Citrus diseases detection using innovative deep learning approach and Hybrid Meta-Heuristic
Citrus farming is one of the major agricultural sectors of Pakistan and currently represents almost 30% of total fruit production, with its highest concentration in Punjab. Although economically impor...
Prevalence and risk factors of the most common multimorbidity among Canadian adults
Background The number of persons living with multimorbidity–defined as the co-occurrence of at least two chronic conditions in the same individual–is growing globally, especially in developed countrie...
Effects of stimuli and contralateral noise levels on auditory cortical potentials recorded in school-age children
Background and objective One of the functions attributed to the auditory efferent system is related to the processing of acoustic stimuli in noise backgrounds. However, clinical implications and the n...
Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models
Down syndrome, resulting from trisomy of human chromosome 21, is a common form of chromosomal disorder that results in intellectual disability and altered risk of several medical conditions. Individua...
Family support and prayer are invaluable coping strategies for our recovery: Experiences of persons living with cardiovascular diseases
Background It is estimated that 61% of deaths caused by Cardiovascular Diseases (CVDs) globally are attributed to lifestyle-related risk factors including tobacco use, alcohol abuse, poor diet, and in...
Critique of enhanced power claimed for Quasi-ANCOVA and Dual-Centered ANCOVA
Two related methods, Quasi-ANCOVA and Dual-Centered ANCOVA, have recently been suggested as a way to get greater power when analyzing data from a before and after study. Both methods use group-mean ce...
Geographical patterns of intraspecific genetic diversity reflect the adaptive potential of the coral Pocillopora damicornis species complex
Marine heatwaves are increasing in intensity and frequency however, responses and survival of reef corals vary geographically. Geographical differences in thermal tolerance may be in part a consequenc...
Vanadate reduction by gram-positive fermentative bacteria isolated from deep-sea sediments on the northern Central Indian Ridge
The oxidation states of vanadium determine its mobility and toxicity, and dissimilatory vanadate reduction has been reported in several microorganisms, highlighting the potential significance of this...
Reconstructing prehistoric lifeways using multi-Isotope analyses of human enamel, dentine, and bone from Legaire Sur, Spain
Megalithism has been repetitively tied to specialised herding economies in Iberia, particularly in the mountainous areas of the Basque Country. Legaire Sur, in the uplands of Álava region, is a recent...
Globalizing opposition to pro-environmental institutions: The growth of counter climate change organizations around the world, 1990 to 2018
More than two decades of social scientific research has identified the growing network of corporations, think tanks, nonprofits, and advocacy organizations that aim to obstruct climate change action w...
Turmeric-black pepper-honey nanoemulsion formulation and antiulcerogenic effect evaluation against ethanol-induced gastric ulcers in rats
Gastric ulcer is a common disorder of the digestive system. The combination of turmeric and honey is known to treat stomach ulcers. However, curcumin, an active component in turmeric, has limitations,...
Respiratory virus detections in children presenting to an Australian paediatric referral hospital pre-COVID-19 pandemic, January 2014 to December 2019
Acute respiratory infections cause significant paediatric morbidity, but for pathogens other than influenza, respiratory syncytial virus (RSV), and SARS-CoV-2, systematic monitoring is not commonly pe...
Female Brain and Endocrinological Research–Veteran (FemBER-Vet) study: A study protocol for identifying endocrinological, lifestyle and psychosocial determinants of brain health outcomes in female veterans for future intervention success
Background Recent studies have demonstrated a greater risk of dementia in female veterans compared to civilians; with the highest prevalence noted for former service women with a d...
Cost-effectiveness of monitoring and liver cancer surveillance among patients with inactive chronic hepatitis B
Patients with chronic hepatitis B infection (CHB) have an increased risk for death from liver cirrhosis and hepatocellular carcinoma (HCC). In the United States, only an estimated 37% of adults with c...
How belief in a just world shapes academic engagement among Chinese college art majors: A cross-level moderated mediation model
The belief in a just world (BJW) is perceived as an individual trait that aids in coping with challenges. This study employed Mplus8.0 and HLM6.08 to analyze 346 questionnaire responses, leading to th...
Tetracycline and chloramphenicol exposure induce decreased susceptibility to tigecycline and genetic alterations in AcrAB-TolC efflux pump regulators in Escherichia coli and Klebsiella pneumoniae
Tigecycline (Tgc), a third-generation tetracycline is found as the last line of defense against multi-drug resistant bacteria. Recent increased rate of resistance to tgc, a human-restricted agent amon...
GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury
Motor dysfunction and muscle atrophy are typical symptoms of patients with spinal cord injury (SCI). Exercise training is a conventional physical therapy after SCI, but exercise intervention alone may...
Gaps in disability inclusion across universities in the United States
Disabled people face social and environmental barriers to higher education, yet there is a dearth of clear, publicly available information on university websites related to accessibility and disabilit...
“The impact of the Little Orange Book on how parents/carers manage symptoms of illness in children: A mixed methods study”
Background Previous literature has highlighted the complexity of supporting an acutely unwell child and the unnecessary use of services by parents/carers. The Little Orange Book (L...