PLoS ONE
Articles in this Issue
Comparative safety and effectiveness of oral anticoagulants in key subgroups of patients with non-valvular atrial fibrillation and at high risk of gastrointestinal bleeding: A cohort study based on the French National Health Data System (SNDS)
Background Risk factors and comorbidities can complicate management of non-valvular atrial fibrillation. We describe and compare real-world safety and effectiveness of direct oral anticoagulants (DOAC...
Effects of a 6-month rowing training program in breast cancer survivors
The purpose of this longitudinal study was to determine the effects of a rowing training program on physical fitness and body composition in female breast cancer survivors (56.78 ± 6.38 years). Over s...
Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles
Recruitment input-output curves of transspinal evoked potentials that represent the net output of spinal neuronal networks during which cortical, spinal and peripheral inputs are integrated as well as...
Phylogenetic relationships and genetic diversity of Tunisian maize landraces
Based on history, maize was first introduced into Tunisia and northern Africa, at large, from the south of Spain. Several subsequent introductions were made from diverse origins, generating new landra...
Expert decision-making in clinicians: An auto-analytic ethnographic study of operational decision-making in urgent care
Objective To conceptualise the cognitive processes of early expert decision-making in urgent care. Background Expert clinicians in the UK frequently determine suitable urgent care patient pathways v...
Was Aristotle right about moral decision-making? Building a new empirical model of practical wisdom
This article presents the development and validation of the Short Phronesis Measure (SPM), a novel tool to assess Aristotelian phronesis...
Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups
The Satisfaction With Life Scale (SWLS) is a widely used self-report measure of subjective well-being, but studies of its measurement invariance across a large number of nations remain limited. Here,...
Optimizing multi label student performance prediction with GNN-TINet: A contextual multidimensional deep learning framework
As education increasingly relies on data-driven methodologies, accurately predicting student performance is essential for implementing timely and effective interventions. The California Student Perfor...
Transformation of sperm structure in Octopus vulgaris: From spermatogenesis to spermatophoric release
The present study describes the differentiation process of male germ cells in Octopus vulgaris, the morphology of sperm in the testis and spermatophore, and the sperm released after the spermatophoric...
Community responses to a novel house design: A qualitative study of “Star Homes” in Mtwara, southeastern Tanzania
Introduction To evaluate the impact of a novel design “Star Home” on the incidence of malaria, respiratory tract infections and diarrheal diseases among children, randomly selected households in Mtwar...
Walking coral: Complex phototactic mobility in the free-living coral Cycloseris cyclolites
Not all corals are attached to the substrate; some taxa are solitary and free-living, allowing them to migrate into preferred habitats. However, the lifestyle of these mobile corals, including how the...
Constructs across a hierarchical, dimensional model of psychopathology show differential associations with social and general cognitive ability
Many psychiatric disorders and associated psychopathology dimensions are related to social cognitive deficits and reduced general cognitive ability. The current study applied a hierarchical, dimension...
Tandem mass tag-based quantitative proteomics and targeted hormone analysis reveal the response to insect herbivory stress in Ginseng (Panax ginseng, L.)
Ginsenosides are the most important secondary metabolites of ginseng. Ginseng has developed certain insect resistance properties during the course of evolutionary environmental adaptation. However, th...
Non-dominant hand contractions do not facilitate performance under pressure in common desktop tasks
Non-dominant hand contractions (NDHCs) have been shown to help expert motor skills in high-pressure scenarios that induce performance anxiety. Most studies of NHDCs under pressure have examined benefi...
Digital financial inclusion, population structure, and consumption upgrades: Evidence from China
This study empirically tests the role of population structure in the process of digital financial inclusion empowering the upgrading of consumption structure by taking 248 prefecture-level cities betw...
Seasonal and periodic patterns in US COVID-19 mortality using the Variable Bandpass Periodic Block Bootstrap
Since the emergence of the SARS-CoV-2 virus, research into the existence, extent, and pattern of seasonality has been of the highest importance for public health preparation. This study uses a novel b...
Interleukin-1β rs16944 and rs1143627 polymorphisms and risk of developing major depressive disorder: A case-control study among Bangladeshi population
Background Epidemiological research suggests that altered levels of cytokine are associated with pathophysiology and the development of major depressive disorder (MDD). Based on earlier study, IL-1β r...
Identifying factors that underpin student decisions to pursue the Doctor of Pharmacy degree at Atlantic Canadian Universities: Protocol for a mixed methods study
Several international studies have investigated academic decision-making in higher education, but there is limited research on students’ choice to study pharmacy in the Canadian context. While there i...
An anonymized, de-identified registry study protocol to determine the effectiveness and safety of weight loss with enavogliflozin in patients with type 2 diabetes mellitus
Sodium-glucose co-transporter 2 inhibitors, such as enavogliflozin, offer promising metabolic benefits for patients with type 2 diabetes (T2D), including glycemic control and improved cardiac function...
Creatine kinase and neuromuscular fatigue responses following differing spells of simulated cricket fast bowling
The fast-bowling action demands repetitive high-intensity whole body movements, imposing complex physical and perceptual demands on players that vary significantly throughout the season. This study ai...
The climate impact and land use of cultivated meat: Evaluating agricultural feedstock production
As global demand for meat continues to rise, alternative and sustainable methods of production are being explored. Cultivated meat (CM) is one such alternative that holds potential for sustainable pro...
Self-acupressure for patients with breast cancer experiencing aromatase inhibitor-associated musculoskeletal symptoms: Protocol for the AcuAIM randomized pilot trial
Background Aromatase inhibitors (AI) reduce hormone receptor-positive breast cancer recurrence risk by about 50%. However, half of AI-treated postmenopausal women report new or worsened musculoskeleta...
Exploring Glypican-3 targeted CAR-NK treatment and potential therapy resistance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer and the second leading cause of cancer-related mortality globally. Despite advancements in current HCC treatment, it r...
Practitioner, patient and public views on the acceptability of mobile stroke units in England and Wales: A mixed methods study
Background Evidence for Mobile Stroke Units (MSUs) demonstrates that onset to treatment times for intravenous thrombolysis can be reduced and access to mechanical thrombectomy migh...
In vivo mapping of sodium homeostasis disturbances in individual ALS patients: A brain 23Na MRI study
Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by significant heterogeneity among patients. 23Na MRI maps abnormal sodium homeostasis that reflects metaboli...