PLoS ONE
Articles in this Issue
HybridBranchNetV2: Towards reliable artificial intelligence in image classification using reinforcement learning
Many artificial intelligence (AI) algorithms struggle to adapt effectively in dynamic real-world scenarios, such as complex classification tasks and object relationship extraction, due to their predic...
Preferential apical infection of Caco-2 intestinal cell monolayers by SARS-CoV-2 is associated with damage to cellular barrier integrity: Implications for the pathophysiology of COVID-19
SARS-CoV-2 can infect different organs, including the intestine. In an in vitro model of Caco-2 intestinal cell line, we previously found that SARS-CoV-2 modulates the ACE2 receptor expression and aff...
Bronchoalveolar lavage single-cell transcriptomics reveals immune dysregulations driving COVID-19 severity
The continuous threats posed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, including the emergence of potentially more infectious and deadly variants...
Pathology and parasitology of free-ranging coyotes from Tennessee and South Carolina
Coyotes are exposed to many parasites and pathogens of veterinary and zoonotic concern. To assess the prevalence of the diseases caused by these microbes, we opportunistically obtained coyote samples...
Effect of organizational change on employee innovation performance: A dual mediation model
Affected by the COVID-19 pandemic and the international development pattern, the international environment has undergone profound changes. Enterprises, as the main body of activities on the front line...
Prevalence and determinants of poor glycemic control among diabetic chronic kidney disease patients on maintenance hemodialysis in Tanzania
Background Poor glycemic control in diabetic chronic kidney disease (CKD) patients on maintenance hemodialysis is of great challenge, resulting in increased risk of morbidity and m...
Talent identification of 12-year old male Australian rules footballers: Physical advantages and prognosis for junior and senior national-level selection
Talent identification focuses on the ability to identify and select young athletes who show potential for future sporting success. The aim of this study was to compare the anthropometry and physical p...
Cross-cultural adaptation and multicentric validation of the Italian version of the Simplified Evaluation of CONsciousness Disorders (SECONDs)
Introduction The Coma Recovery Scale-Revised (CRS-R) is the recommended tool to assess consciousness in patients with prolonged Disorders of Consciousness (pDoC). However, the time needed to administe...
Breastfeeding self-efficacy status and associated factors among postpartum mothers at Hadiya Zone public hospitals, Southern Ethiopia
Background Breastfeeding is a crucial health-promoting behavior that has several positive effects on the health of both mothers and newborns. Breastfeeding self-efficacy (BFSE) status is an important...
Assessment of potential dominant factors for brownfield landscape regeneration: A case study in Xi’an, China
Rapid global urbanization has made brownfield reuse a vital issue for sustainable urban development. However, the regeneration of brownfield landscapes is a complex and lengthy process that requires a...
Quantitative nylon monomerization by the combination of chemical pretreatment and enzymatic hydrolysis using nylon hydrolases
Nylons, derived from fossil fuels, are widely used for their toughness and flexibility, but they pose environmental concerns due to their low biodegradability. This study explored an efficient method...
Electrochemically reduced graphene oxide integrated with carboxylated-8-carboxamidoquinoline: A platform for highly sensitive voltammetric detection of Zn(II) ion by screen-printed carbon electrode
Zinc has been demonstrated to boost immune response during SAR-CoV-2 infection, where it prevents coronavirus multiplication. Clinical investigations have testified to its beneficial effects on respir...
Comparative analysis of selected methods of carbapenemase determination among clinical Klebsiella pneumoniae
Klebsiella pneumoniae is a typical opportunistic pathogen that exhibits multiple virulence factors and antibiotic resistance conditioning mechanisms. Carbapenemases are enzymes that help bacteria to e...
How do inside directors affect corporate R&D investment? The moderating role of CEO equity incentives
This study aims to reveal whether non-CEO inside directors can promote corporate research and development (R&D) investment. Using a panel data of 3,002 Chinese manufacturing listed firms from 2011...
Coupling coordination of digital village construction and high-quality agricultural development in China
This study aims to investigate the coupling coordination relationship between digital village construction and high-quality agricultural development in China, along with influencing factors, in order...
Dynamics of multiple sustainable agricultural intensification practices adoption: Application of the intertemporal multivariate probit model
Applying an intertemporal multivariate probit model, we reveal complex complementarity and substitution effects as well as new insights on the drivers of adopting input-intensive and natural resource...
Introduction risk of fire ants through container cargo in ports: Data integration approach considering a logistic network
Invasive alien species introduced to ports through cargo containers have destroyed the biodiversity worldwide. The introduction risk at ports must be estimated to control the early stages of invasion....
Trajectory tracking sliding mode control for vertical take-off and landing aircraft based on double loop and global Lipschitz stability
Vertical Take-Off and Landing (VTOL) aircraft excel in their ability to maneuver in limited spaces, making them ideal for a variety of uses including urban air mobility, emergency response, and disast...
Measles neutralising antibody levels in patients receiving intravenous immunoglobulin treatment – a sub-analysis of a randomized, cross-over bioequivalence trial
Background Intravenous immunoglobulin is a replacement therapy for patients living with primary immunodeficiencies. Each batch of intravenous immunoglobulin is required by the Food and Drug Administra...
Correction: The salivary microbiota of patients with acute lower respiratory tract infection–A multicenter cohort study
Comprehensive cDNA cloning and putative feature analysis of endogenous cellulases possessed by the Pacific oyster, Crassostrea gigas
Previous studies have examined the cellulase activity of Crassostrea gigas (Pacific oyster) and suggested its potential utilization of terrestrial lignocellulose. However, no studies have been conduct...
Efficacy and safety of dexamethasone or triamcinolone in combination with anti-vascular endothelial growth factor therapy for diabetic macular edema: A systematic review and meta-analysis with trial sequential analysis
Background The clinical efficacy of anti-vascular endothelial growth factors (anti-VEGFs), corticosteroids, and their combined treatment for diabetic macular edema (DME) has been substantiated by nume...
Nucleus accumbens D2-expressing neurons: Balancing reward and licking disruption through rhythmic optogenetic stimulation
Nucleus accumbens (NAc) dopamine D1 receptor-expressing neurons are known to be critical for processing reward and regulating food intake. However, the role of D2-expressing neurons in this nucleus re...
A catechol-O-methyltransferase genetic variant impacts functional movement in tactical athletes
Functional movement is a valuable indicator of physical performance, injury risk, and/or musculoskeletal impairment following injury. However, genetic variation and gene–environment interactions that...