PLoS ONE
Articles in this Issue
Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study
Rationale Robust COVID-19 outcomes classification is important for ongoing epidemiology research on acute and post-acute COVID-19 conditions. Protocolized medical record review is an established metho...
MAP1LC3C repression reduces CIITA- and HLA class II expression in non-small cell lung cancer
In the last decade, advancements in understanding the genetic landscape of lung squamous cell carcinoma (LUSC) have significantly impacted therapy development. Immune checkpoint inhibitors (ICI) have...
Assessment of public awareness and perspectives towards adverse drug reaction reporting system in Karachi, Pakistan
Background Public involvement in reporting adverse drug reactions (ADRs) generates a broader database on drug safety. Underreporting remains a hindrance to implementing an effective pharmacovigilance...
Role of the platelet-lymphocyte ratio as a prognostic indicator in patients with intracranial hemorrhage: A systematic review and meta-analysis
Background The prognostic value of platelet-lymphocyte ratio (PLR) in ischemic stroke had been investigated in previous studies. However, the results of studies on PLR in patients with intracranial he...
Identifying children who develop severe chronic kidney disease using primary care records
Background Understanding whether symptoms suggestive of chronic kidney disease (CKD) are reported to primary care before diagnosis may provide opportunities for earlier detection, thus supporting stra...
Enhancing contact recommendation in social platforms through mental health awareness: Exploring Anorexia Nervosa as a case study
We analyze and propose a solution for the exposure of vulnerable users to harmful content during their interaction with contact recommender systems in social platforms. Our approach is dedicated to ma...
The role of peer support in coping and adjustment to dialysis and transplantation: Study protocol
Introduction People with kidney failure receiving dialysis or kidney transplantation find it difficult to adapt to treatment related routines and restrictions, and feel frustrated when their expectati...
Hydrogeochemical and isotopic analysis for interpreting the formation of the complex geothermal system in the Guide Basin, Northeastern Tibetan Plateau
The Guide Basin, located in the northeastern Tibetan Plateau, is rich in geothermal resources. However, whether the genesis of all geothermal waters in the basin is consistent remains an unresolved qu...
Identifying engagement strategies for Hispanic youth with anxiety: A youth-centered, Design-Thinking approach
Anxiety is the most common and widespread mental health disorder impacting youth between the ages of 10–19. Youth of color including Hispanic youth are disproportionately impacted. Fewer than 20% of y...
The systematic techno-stylistic and chemical study of glass beads from post-15th century West African sites
The systematic chemical analysis of large collections of archaeological glass beads is essential to better understand trade patterns at different times around the world. Glass beads’ trade towards and...
Effects of whole-body vibration training as an adjunct to conventional rehabilitation exercise on pain, physical function and disability in knee osteoarthritis: A systematic review and meta-analysis
Background Knee osteoarthritis (KOA) is a prevalent degenerative joint condition that impairs mobility and quality of life. While whole-body vibration training (WBVT) shows promise as an adjunct to co...
Saikosaponin A alleviates depressive-like behavior induced by reserpine in mice by regulating gut microflora and inflammatory responses
Saikosaponin A (SSA), a key ingredient of Chaihu-Shugan-San, has been shown to possess anti-inflammatory, antioxidant and antidepressant properties. Therefore, the present study aimed to investigate t...
Impact of the COVID-19 pandemic on outcomes of acute ischemic stroke patients treated with endovascular therapy: A multicenter Canadian study
Objective The novel coronavirus disease 2019 (COVID-19) pandemic led to the implementation of wide-ranging institutional infection control protocols. The purpose of this study is to determine the effe...
Why are individuals tracing travel trends? A case study of City Walk in Malaysia
Studying the emerging travel trends of City Walk is a beneficial activity for young groups. However, there is a lack of research and understanding regarding the motivation and mechanism behind these t...
Validity of heart rate measurements in wrist-based monitors across skin tones during exercise
Purpose To evaluate the accuracy of a wrist-based heart rate (HR) monitor at different exercise intensities across different skin tones. Methods Using a cross-sectional design, we compared HR measur...
Navigating Industry 4.0: Leveraging additive technologies for competitive advantage in Colombian aerospace and manufacturing industries
Industry 4.0 initiatives aim to improve competitive advantage. Additive technologies are a technological innovation and have great potential in a developing country like Colombia, The study analyzes h...
Enhancing machine learning performance in cardiac surgery ICU: Hyperparameter optimization with metaheuristic algorithm
The healthcare industry is generating a massive volume of data, promising a potential goldmine of information that can be extracted through machine learning (ML) techniques. The Intensive Care Unit (I...
Barriers and facilitators of adherence to treatment interventions for COPD amongst individuals from minority ethnic communities: Meta-ethnography
Objective Numerous studies have documented the low adherence rate to treatment interventions for Chronic Obstructive Pulmonary Disease (COPD) amongst minority ethnic communities. This systematic meta-...
The impact of climate variability on agricultural employment in Mexico from 1980–2017
Employment in the agricultural sector is highly dependent on climate. Most agricultural jobs worldwide rely on predictable precipitation, in terms of both quantity and seasonality. Mexico is a largely...
Evaluation of a home-based parenting support programme—Parenting Young Children—For parents with intellectual and developmental disabilities when there is a risk for neglect: Study protocol for a multi-centre study
Introduction Parents with intellectual and developmental disabilities (IDDs) often need parenting support, but there are few evidence-based programmes adapted to their cognitive needs. Parenting Young...
DeepKymoTracker: A tool for accurate construction of cell lineage trees for highly motile cells
Time-lapse microscopy has long been used to record cell lineage trees. Successful construction of a lineage tree requires tracking and preserving the identity of multiple cells across many images. If...
Explore the possible influence of Sjogren’s syndrome on thyroid cancer: A literature data mining and meta-analysis
Objectives To explore the potential influence of Sjogren’s syndrome (SS) on thyroid cancer (TC). Methods First, a literature data mining (LDM) approach was used to reconstruct functional pathways co...
Implementation research to develop an optimized delivery model for effective implementation of evidence-based interventions to reduce stillbirth in India: A study protocol
Background Stillbirth remains a public health concern in India, despite a decrease in reported rates. Inconsistent data collection hampers clear understanding the burden of stillbirth, and interventio...
Cost analysis of corneal tissue processing: A scoping review protocol
Introduction Diseases affecting the cornea are a group of pathological conditions responsible for the main causes of blindness worldwide. Corneal transplantation aims to replace dysfunctional corneal...
A multicenter cross-sectional survey of the role of community pharmacists, attitudes, and perceptions in preventing and controlling cardiovascular diseases
Background Cardiovascular diseases are a leading cause of mortality globally and impose suffering and economic difficulties, particularly in low- and middle-income countries. Community pharmacists pre...