PLoS ONE
Articles in this Issue
Structure and diversity of intestinal methanogens in black carp (Mylopharyngodon piceus), grass carp (Ctenopharyngodon idella) and water samples
The present research investigation aims to examine the community features of methanogens in the intestinal tract of black and grass carp, as well as their association with methanogens in water samples...
Meriones unguiculatus serves as a spontaneous primary aldosteronism rodent model
Background Primary aldosteronism (PA) is the most common form of endocrine hypertension. The available animal models of PA rely on gene manipulation, thus fail to duplicate the general pathological pr...
Optimising test intervals for individuals with type 2 diabetes: A machine learning approach
Background Chronic disease monitoring programs often adopt a one-size-fits-all approach that does not consider variation in need, potentially leading to excessive or insufficient support for patients...
Characterizing plasma and cerebrospinal fluid biomarkers relevant to neurodegeneration in captive olive baboons (Papio anubis)
Alzheimer’s disease and related dementias (ADRD) present a significant global disease burden that is only expected to grow in the future. As such, there is a need to develop and investigate biomarkers...
Multifunctional molecular hybrid for targeted colorectal cancer cells: Integrating doxorubicin, AS1411 aptamer, and T9/U4 ASO
Colorectal cancer (CRC) poses a global health challenge, with current treatments often harming both cancerous and normal cells. To improve efficacy, a multifunctional drug delivery platform has been d...
A systematic review and meta-analysis of psychological treatments to improve sleep quality in university students
Objective This paper reviews the literature evaluating psychological treatments to improve sleep quality in young adult university students. Method Participants (N = 6179) were young adult (aged 18–...
Sex and age differences in cardiovascular risk factors and lifestyle in patients recently diagnosed with diabetes mellitus: A cross-sectional study in Spanish primary health care
Aims To describe the main characteristics of patients recently diagnosed with DM regarding cardiovascular risk factors and diabetes-related complications, compare possible differences according to sex...
Image captioning in Bengali language using visual attention
Automatically generating image captions poses one of the most challenging applications within artificial intelligence due to its integration of computer vision and natural language processing algorith...
Formulation and evaluation of atorvastatin calcium trihydrate Form I tablets
Solid forms transformations and new crystal structures of an active pharmaceutical ingredient (API) can occur due to various manufacturing process conditions, especially if the drug substance is formu...
You can’t see what you don’t measure! A scoping review of measurements of gender-based violence, its determinants and consequences in academia
Introduction Assessing the problem of gender-based violence in academia internationally is challenging due to a lack of empirical evidence and differences in how it is measured. The contribution of th...
Experiences of rehabilitation one year after breast cancer diagnosis–A focus group study from the ReScreen randomized controlled trial
Background Treatment for breast cancer poses major challenges and leads to a variety of side-effects and problems that affect life for a long time. Experiences and symptoms vary, and research indicate...
Sickness absenteeism among nurses after the COVID-19 pandemic: A study protocol
Introduction Sickness absenteeism among the nurses in Malaysia is not fully understood. Complicated with the increase in workload and mental stress during the COVID-19 pandemic and the manifestation o...
From larva to adult: In vitro rearing protocol for honey bee (Apis mellifera) drones
Development of a successful in vitro rearing protocol has been essential for pesticide safety assessment of immature honey bee workers under laboratory conditions. In contrast, pesticide safety testin...
Investigating the safety of physical rehabilitation with critically ill patients receiving vasoactive drugs: An exploratory observational feasibility study
Background Physical rehabilitation of critically ill patients may improve physical outcomes; however, the relative benefits and risks with patients requiring vasoactive drugs is currently unknown. A f...
The impact of carbohydrate quality on gut health: Insights from the NHANES
Background High- and low-quality carbohydrate diets are linked to gut health. However, their specific relationship with constipation or diarrhea is unclear. This study uses 2005–2010 NHANES data to ex...
Exploring the underlying mechanisms of customers’ intention to adopt product recommendations from live streamers: A moderated mediation approach
Live streaming has emerged as one of the indispensable channels for product information dissemination. Product recommendations from live streamers play an increasingly important role in customers’ pur...
Understanding the aliya pulsed electric field dose-response relationship: Implications for ablation size, thermal load, and immune response in an orthotopic murine breast cancer model
Aliya®Pulsed Electric Field (PEF) technology is an emerging strategy in the field of cancer treatment, offering a novel approach to ablation therapy that does not rely on thermal mechanisms. By employ...
Sample Size Impact (SaSii): An R script for estimating optimal sample sizes in population genetics and population genomics studies
Obtaining large sample sizes for genetic studies can be challenging, time-consuming, and expensive, and small sample sizes may generate biased or imprecise results. Many studies have suggested the min...
EEG theta and alpha oscillations during tactical decision-making: An examination of the neural efficiency hypothesis in volleyball
According to the neural efficiency hypothesis (NEH), individuals with higher expertise in a domain use their brain more efficiently when processing domain-specific tasks and show more efficient brain...
Genetic diversity and population structure analysis of Forsythia ovata, a Korean endemic, based on genotyping-by-sequencing
The perennial shrub Forsythia ovata Nakai, native to the Korean Peninsula, has a highly restricted natural habitat, occurring only in a small area within the Baekdudaegan Mountain Range located in Gan...
Current and emerging approaches to cochlear immunosuppression with translation to human inner ear stem cell therapy: A systematic review
Hearing loss is a significant health burden across all stages of life. One in 5 people suffer hearing loss, with 5% of the world’s population experiencing disabling hearing loss. A large proportion of...
On people’s perceptions of climate change and its impacts in a hotspot of global warming
The Hindu Kush Himalayan region is a global hotspot for climate change and highly vulnerable to its direct and indirect impacts. Understanding people’s perception of climate change is crucial for effe...
Zika virus modulates arthropod histone methylation for its survival in mosquito cells
Zika virus (ZIKV) is a mosquito-borne human pathogen that causes mild febrile illness in adults and severe neurological complications and microcephaly in newborns. Studies have reported that ZIKV modu...
The effect of acupuncture on quality of life in patients with irritable bowel syndrome: A systematic review and meta-analysis
Background Acupuncture has been used to improve the quality of life (QoL) of patients in clinical settings. However, the effect of acupuncture on QoL in patients with irritable bowel syndrome (IBS) re...
Optimizing mechanical ventilation: Personalizing mechanical power to reduce ICU mortality ‐ a retrospective cohort study
Background Mechanical ventilation, a crucial intervention for acute respiratory distress syndrome (ARDS), can lead to ventilator-induced lung injury (VILI). This study focuses on individualizing mecha...