PLoS ONE
Articles in this Issue
Investigation of severe dengue outbreak in Maumere, East Nusa Tenggara, Indonesia: Clinical, serological, and virological features
Background Dengue, an acute febrile disease caused by dengue virus (DENV) infection, is endemic to Indonesia. During early 2020, an outbreak of severe dengue occurred in Maumere, East Nusa Tenggara p...
Deformation monitoring and safety stability evaluation study of high-altitude limestone dumps
We employed synthetic aperture radar interferometry (InSAR) to assess the slope stability of a high-altitude landfill in Sangri County, Shannan, Tibet. To address the unique climatic conditions of hig...
Spatio-temporal analysis of human brucellosis distribution in Neyshabur, Iran from 2015 to 2022, a cross-sectional study
Background Human brucellosis is a global endemic disease and a significant public health concern. This cross-sectional study aims to explore the characteristics of human brucellosis, as well as its sp...
Unsupervised neural network-based image stitching method for bladder endoscopy
Bladder endoscopy enables the observation of intravesical lesion characteristics, making it an essential tool in urology. Image stitching techniques are commonly employed to expand the field of view o...
Videos engaging in conspiracy theories: Promoting or refuting foreign-pseudohistory on the video-sharing website (Bilibili)
Foreign pseudohistory, as one format of conspiracy theories, is an unverified discourse explicitly stating that a culture, civilization, or achievement outside one’s homeland country did not exist, do...
Development and validation of interpretable machine learning models for triage patients admitted to the intensive care unit
Objectives Developing and validating interpretable machine learning (ML) models for predicting whether triaged patients need to be admitted to the intensive care unit (ICU). Measures The study analy...
Transcriptomic analysis reveals cloquintocet-mexyl-inducible genes in hexaploid wheat (Triticum aestivum L.)
Identification and characterization of genes encoding herbicide-detoxifying enzymes is lacking in allohexaploid wheat (Triticum aestivum L.). Gene expression is frequently induced by herbicide safener...
Identification of the key role of IL-17RB in the treatment of osteoarthritis with Shaoyao Gancao decoction: Verification based on RNA-seq and bioinformatics analysis
Background Shaoyao Gancao Decoction (SGD) is a classic and representative oral administration of traditional Chinese medicine formula. It is composed of two Chinese herbal medicines, Paeoniae Radix Al...
Proteomic and metabolomic profiling reveals the underlying molecular mechanisms in modified alternate-day fasting-mediated protection against Diabetic kidney disease
Background Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease, and while lifestyle interventions like intermittent fasting have shown promise in treating diabetes, the impact o...
Use of a mouse model for the isolation of Borrelia puertoricensis from soft ticks
The isolation of tick-borne relapsing fever (TBRF) spirochetes has proven to be a useful tool to understand their distribution in geographic areas where the tick vectors inhabit. However, their isolat...
Spatiotemporal variation in fish species distribution and abundance in the Vaishav stream, Kashmir Himalaya–India
Exploring the intricate dynamics of aquatic ecosystems present study investigates the spatio-temporal variations in the ecological parameters of the fish community within the Vaishav stream, Kashmir H...
Integration of pharmacodynamics, network pharmacology and metabolomics to elucidate the effect and mechanism of Jingfang Granule in the treatment of Paraquat induced Pulmonary fibrosis
Objective One of the main risk factors of COVID-19 is Pulmonary fibrosis (PF). The protective effect of Jingfang Granule (JF) to bleomycin-induced PF has been confirmed in our previous studies. This w...
Changes in vaginal Ureaplasma and Lactobacillus due to antibiotic regimen for premature rupture of membranes
Preterm premature rupture of membranes (PPROM) is associated with preterm delivery and neonatal complications. PPROM is often complicated by intra-amniotic inflammation and/or microbial invasion of th...
miR-455-3p has superior diagnostic potential to PSA in peripheral blood for prostate cancer
Background Prostate-specific antigen (PSA) is commonly used as a biomarker to diagnose and predict the course of prostate cancer (PCa). However, PSA detection is susceptible to changes in the physiolo...
Notch2/3-DLL4 interaction in urothelial cancer cell lines supports a tumorigenic role of Notch signaling pathways in bladder carcinoma
Introduction The Notch pathway plays an important role in many aspects of cancer biology and acts in a dichotomous way in bladder cancer. The mechanisms behind this behavior are still elusive. Here, w...
Nutrition educational interventions for athletes related to low energy availability: A systematic review
Low energy availability (LEA) is a prevalent concern among athletes, often attributed to intentional or unintentional under-fueling behaviors. Nutritional and energy availability educational intervent...
Measuring progress in availability and readiness of Basic emergency obstetric and newborn care (BEmONC) services in Bangladesh, 2014–2017
Increasing the availability and readiness of basic emergency obstetric and newborn care (BEmONC) services is essential for improving maternal and neonatal health. However, little is known about any pr...
Cost profiles of cancer patients at the end of life: Estimates from the EPICOST-study
Objectives The study aims to analyze care and cost patterns in the Veneto region for cancer patients in the final phase of their disease. Methods The study cohort includes adult patients alive on 1....
No detectable effect of urbanization on genetic drift or gene flow in specialist herbivorous insects of milkweed
Urbanization is hypothesized to isolate populations and restrict dispersal, leading to reduced genetic diversity and increased genetic differentiation. We tested this hypothesis in specialist herbivor...
Interval price prediction of livestock product based on fuzzy mathematics and improved LSTM
Livestock product prices serve as a barometer and bellwether for the agricultural market. However, traditional point prediction techniques focus mainly on tracking or fitting, resulting in limited inf...
Bioinformatics analysis of genes associated with disulfidptosis in spinal cord injury
Research findings indicate that programmed cell death (PCD) plays a pivotal role in the pathophysiology of spinal cord injury (SCI), and a recently discovered form of cell death, disulfidptosis, has e...
Maternity care providers’ experiences of work-related serious events (MATES): An International survey
Internationally, many women experience physiological childbirth with positive experiences and good health outcomes for them and their baby. For some, due to health complications and context of childbi...
Long-term consumption of hydrogen-rich water provides hepatoprotection by improving mitochondrial biology and quality control in chronically stressed mice
Background Chronic stress has emerged as a prevalent facet of contemporary existence, significantly jeopardizing overall bodily health. The liver, a pivotal organ responsible for metabolic equilibrium...
Risk factors associated with the recurrence of diabetic foot ulcers: A meta-analysis
Aims Diabetic foot ulcers have caused significant medical, economic and social consequences for patients, families and society. With appropriate treatment, many diabetic foot ulcers can heal, temporar...
The perspectives of women on sustainable fashion consumption: Comparative study of university teachers and students
In the recent decade, fashion industry has been receiving extensive criticisms for having a significant negative impact on the environment and people. As the counterpoint of rapid pace and cheap price...