PLoS ONE
Articles in this Issue
Transcriptome analyses reveal differences in the response to temperature in Florida and Northern largemouth bass (Micropterus spp.) during early life stages
Temperature is one of the most relevant factors influencing the development of aquatic species, making it a key parameter to consider for aquaculture. Largemouth bass (LMB; Micropterus spp.) are highl...
Assessing benthic invertebrate vulnerability to ocean acidification and de-oxygenation in California: The importance of effective oceanographic monitoring networks
Greenhouse gas emissions from land-use change, fossil fuel, agriculture, transportation, and electricity sectors expose marine ecosystems to overlapping environmental stressors. Existing climate vulne...
Transcriptomic analysis of human primary T cells after short-term leucine-deprivation and evaluation of kinase GCN2’s role in regulating differential gene expression
Chimeric Antigen Receptor T (CAR-T) cells offer a promising strategy for cancer treatment. These CAR-T cells are either autologous or allogeneic T cells that are genetically modified to express a chim...
Mean platelet volume as a biomarker for liver fibrosis in patients with Non-alcoholic fatty liver disease
Introduction Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease worldwide. Accurate assessment of liver fibrosis is essential for the prognosis and manageme...
A community based, bottom-up, multi-pronged, technology integrated approach to enhance tuberculosis related awareness and treatment adherence in Uganda: The ACTS model
Background Tuberculosis (TB) is still a major public health challenge globally and Uganda is one among the top 30 high TB burden countries. One of the key factors determining TB treatment success rate...
Couples and parenting dynamics during Covid-19 pandemic: A systematic review of the literature
The COVID-19 pandemic constituted a public health crisis bound to impact couples, parents, and families globally. However, the literature on the impacts of COVID-19 in families is not yet integrated....
The influence of survival conditions on farmer willingness to participate in non-grain conversions of cultivated land based on the SOR model
Non-grain conversions (NGC) of cultivated land pose a great threat to national food security, and farmers are the direct actors in the NGC of cultivated land. Exploring the influence of farmer’ surviv...
Fixed point results for ℑ-Contractions in JS-generalized metric spaces with an application
The goal of this work is to establish ℑ-contractions and to show some novel fixed point theorems for these contractive conditions in the setting of generalized metric spaces in the sense of Jleli and...
Top-down effects on translucency perception in relation to shape cues
It is well established that object shape perception significantly influences the perception of translucency. However, how object shape cues such as motion and binocular disparity affect the perception...
Identification of biomarkers in Alzheimer’s disease and COVID-19 by bioinformatics combining single-cell data analysis and machine learning algorithms
Background Since its emergence in 2019, COVID-19 has become a global epidemic. Several studies have suggested a link between Alzheimer’s disease (AD) and COVID-19. However, there is little research in...
Active tuberculosis in household contacts of bacteriologically confirmed pulmonary tuberculosis patients: A multicenter study finding the ‘Missed One’ in Central Ethiopia
Background There was a ‘missing millions’ gap between the incidence of tuberculosis (TB) cases and the notified cases. In many TB high-burden countries, only about 25% of household contacts (HHCs) com...
Leveraging natural language processing for efficient information extraction from breast cancer pathology reports: Single-institution study
Background Pathology reports provide important information for accurate diagnosis of cancer and optimal treatment decision making. In particular, breast cancer has known to be the most common cancer i...
Analysis of differential expression of matrix metalloproteinases and defensins in the nasopharyngeal milieu of mild and severe COVID-19 cases
Introduction A subset of COVID-19 disease patients suffers a severe form of the illness; however, underlying early pathophysiological mechanisms associated with the severe form of COVID-19 disease rem...
Inverse association between prognostic nutritional index and kidney stone prevalence: A population-based study
Background Kidney stones frequently occur due to metabolic disorders, dietary habits, and lifestyle influences. The Prognostic Nutritional Index, which reflects an individual’s nutritional condition,...
Transcriptomic analysis of benznidazole-resistant Trypanosoma cruzi clone reveals nitroreductase I-independent resistance mechanisms
The enzyme nitroreductase I (NTRI) has been implicated as the primary gene responsible for resistance to benznidazole (Bz) and nifurtimox in Trypanosoma cruzi. However, Bz-resistant T. cruzi field iso...
Research on the evolution and evaluation of Chinese sports industry policies based on intelligent analysis
In recent decades, with the support and traction of a number of key policy steps, the scale of China’s sports industry has achieved a new leap. The optimization of industrial structure has made new pr...
Carsharing operation optimization with the comprehensive consideration of economic and social benefits
Carsharing is regarded as a new mode of transportation that can meet the diversity of travel demands. This study develops a bi-level programming model to design operating strategies aiming to maximize...
Selecting indicators for the measurement of low-value care using German claims data: A three-round modified Delphi panel
By reducing healthcare services that offer little benefit or potential harm to patients (low-value care), resources can be redirected towards more adequate treatments, improving healthcare efficiency...
Prevalence of burnout syndrome in Brazilian anesthesiologists during the COVID-19 pandemic: A cross-sectional survey
Background Burnout syndrome, one of the consequences of chronic exposure to stressful, is more prevalent among physicians compared to the general population. Anesthesiology, alongside high-stress spec...
Effect of using home-based dynamic intermittent pneumatic compression therapy during periods of physical activity on functional and vascular health outcomes in chronic stroke: A randomized controlled clinical trial
Background Intermittent pneumatic compression (IPC) therapy may benefit stroke patients by eliciting more intensive training sessions that may result in better health, mobility and ultimately quality...
Targeting beta-lactamase activity with Oxacyclohexadecan-2-one in carbapenem-resistant uropathogenic E. coli: A molecular simulation approach
Urinary tract infections caused by uropathogenic Escherichia coli (E. coli) are a global health concern, with rising rates and antibiotic resistance demanding novel treatments. Therefore, in this stud...
Multi-agent deep reinforcement learning-based robotic arm assembly research
Due to the complexity and variability of application scenarios and the increasing demands for assembly, single-agent algorithms often face challenges in convergence and exhibit poor performance in rob...
Altered resting-state amplitudes of low-frequency fluctuations in offspring of parents with a diagnosis of bipolar disorder or major depressive disorder
Offspring of parents with bipolar disorder (BD) or major depressive disorder (MDD) are at high biological risk (HR) of these disorders given their significant heritability. Thus, studying neural corre...
Analysis of the network structure characteristics and influencing factors of regional tourism economy
The tourism economic network is a crucial factor influencing regional tourism interrelations and economic behaviors. This study selects Sichuan Province, China, as the research area and employs social...
An integrated approach for advanced vehicle classification
This study is dedicated to addressing the trade-off between receptive field size and computational efficiency in low-level vision. Conventional neural networks (CNNs) usually expand the receptive fiel...