PLoS ONE
Articles in this Issue
Barriers and facilitators to HIV viral load suppression among adolescents living with HIV in Lubumbashi, Democratic Republic of the Congo: A qualitative study
Background Antiretroviral therapy (ART) has been pivotal in improving the lives of adolescents living with HIV (ALHIV) globally. However, achieving and maintaining viral load suppression (VLS) among A...
Households willingness to join and pay for community-based health insurance: implications for designing community-based health insurance based on economic Status in Ethiopia
Background Despite the encouraging results achieved by community-based health insurance in Ethiopia, the program faces significant challenges. Among these challenges is the current practice where prem...
The impact of clot permeability on platelet fluxes toward its surface
Platelet aggregation is regulated by a series of chemical reactions that control platelet adhesion on a thrombogenic surface. These reactions are influenced by the complex interaction between reaction...
Identification of glucocorticoid-related genes in systemic lupus erythematosus using bioinformatics analysis and machine learning
Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease that has significant impacts on patients’ quality of life and poses a substantial economic burden on society. Objectiv...
Effect of intraocular pressure on crystalline lens oscillations: a computational study using porcine eye model
This study addresses a crucial knowledge gap by investigating the impact of intraocular pressure (IOP) on the wobbling characteristics of the crystalline lens in an ex vivo setting. It utilizes previo...
Academic research values: Conceptualization and initial steps of scale development
We draw on value theory in social psychology to conceptualize the range of motives that can influence researchers’ attitudes, decisions, and actions. To conceptualize academic research values, we inte...
Punicic acid alleviates methylglyoxal-induced oocyte dysfunction during in vitro maturation in mouse species
Dicarbonyl stress, characterized by the abnormal accumulation of reactive dicarbonyl metabolites and advanced glycation end-products (AGEs), is implicated in various pathological conditions, including...
Enrichment of Porphyromonas gingivalis in colonic mucosa-associated microbiota and its enhanced adhesion to epithelium in colorectal carcinogenesis: Insights from in vivo and clinical studies
Objectives The oral–gut axis is believed to play a role in the pathogenesis of colorectal cancer (CRC). Previous studies have demonstrated the transmission of oral microbiota to the gut, disrupting gu...
Unleashing the green potential: Unraveling the power of environmental concerns in driving employees’ green behavior
This study investigates how environmental concerns influence employees’ green behavior within businesses, with a focus on the roles of attitude, green knowledge, and perceived behavioral control, unde...
Tris inhibits a GH1 β-glucosidase by a linear mixed inhibition mechanism
Here we demonstrate that Tris (2-amino-2-(hydroxymethyl)-1,3-propanediol), largely used as a buffering agent, is a linear mixed inhibitor ( K i...
Screening potential anti-osteoarthritis compounds using molecular docking based on MAPK and NFκB pathways and validating their anti-osteoarthritis effect
Osteoarthritis is an extremely common disease. However, it lacks effective nonsurgical treatments. Molecular docking has been widely used in drug discovery. However, no studies focus on screening anti...
A machine learning-based model for predicting survival in patients with Rectosigmoid Cancer
Background The unique anatomical characteristics and blood supply of the rectosigmoid junction confer particular significance to its physiological functions and clinical surgeries. However, research o...
Impact of work-family conflict on work engagement among female university teachers: Evidence from China
University faculty, including female teachers, often face work-family conflict (WFC) which subsequently impacts their work engagement. This study analyzes data from 489 questionnaires using Mplus 8.0...
An interoperable web-based platform to support health surveillance against latent tuberculosis infection in health care workers and students: The evolution of CROSSWORD study protocol
Background Tuberculosis (TB) prevention is a major goal in teaching hospital setting. Because of the possible progression or reactivation of latent disease, the screening of both health-care workers (...
Time-restricted eating in early-stage Huntington’s disease: A 12-week interventional clinical trial protocol
Huntington’s disease (HD) is a devastating neurodegenerative disorder characterized by a variety of debilitating symptoms including abnormal motor control, cognitive impairment, and psychiatric distur...
CN metabolism and nitrogen use efficiency of rice with different nitrogen form and rate
Nitrogen (N) is one of crucial mineral nutrients for rice cultivation, however excessive N application has resulted in lower utilization and thus occasionally attributes to environmental impacts. Simu...
Ten years of visual field change in people living with diabetes: A prospective longitudinal study
Background A better characterization of diabetic retinopathy (DR) may be helpful to monitor early disease, predict progression of DR, and to evaluate new treatment strategies. Visual function has bee...
Enhanced catalytic performance of palladium nanoparticles supported on novel N and F co-doped bio-carbon material for 5-hydroxymethylfurfural conversion
A novel N, F-co-doped bio-carbon material derived from cellulose was successfully developed via a convenient and simple strategy. The obtained bio-carbon material was characterized with various techni...
Sleep disturbances among young adult dual users of cigarettes and e-cigarettes: Analysis of the 2020 National Health Interview Survey
Background The increasing use of conventional cigarettes and e-cigarettes among young adults (18-35 years) in the US raises significant health concerns, including impacts on sleep. While smoking’s ad...
Impact of double-bolus tracking to individualize scan timing of the portal venous phase in preoperative computed tomography colonography angiography for right-sided colon cancer
Aim In computed tomography colonography angiography (CTC-A), used for preoperative screening of right-sided colon cancer, the timing of venous phase imaging is conventionally determined by a fixed-de...
Effects of inspiratory muscle training on respiratory function, diaphragmatic thickness, balance control, exercise capacity and quality of life in people after stroke: A randomized controlled trial protocol
Background Stroke is associated with diaphragmatic weakness and impaired respiratory function as well as balance impairment. The role of inspiratory muscle training (IMT) on improvement of respirator...
A systematic review and meta-analysis on pharmacist-led interventions for the management of peptic ulcer disease
Pharmacists are essential for developing pharmacotherapy plans, conducting clinical assessments, and overseeing drug monitoring. Their interventions help prevent medication errors and adverse drug eve...
Optimization of Decision Support Technology for Offshore Oil Condition Monitoring with Carbon Neutrality as the Goal in the Enterprise Development Process
This study aims to explore the integration of the Faster R-CNN (Region-based Convolutional Neural Network) algorithm from deep learning into the MobileNet v2 architecture, within the context of enterp...
Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4+ T cells during blood-stage Plasmodium infection
Plasmodium-specific CD4+ T cells differentiate into effector and memory subsets during experimental malaria, via mechanisms that remain incompletely characterised. By mining scRNA-seq data of CD4+ T c...
Mental health policy implementation in low- and middle-income countries: a realist review protocol
Introduction Formulating and implementing mental health policy is foundational to public mental health. The implementation of mental health policy varies in low- and middle-income countries (LMICs), w...