An interoperable web-based platform to support health surveillance against latent tuberculosis infection in health care workers and students: The evolution of CROSSWORD study protocol
Abstract
Background Tuberculosis (TB) prevention is a major goal in teaching hospital setting. Because of the possible progression or reactivation of latent disease, the screening of both health-care workers (HCWs) and students is an important issue in the TB control program. Objective to deploy a web-based platform interoperating health surveillance systems from different hospitals to define models based on the highlighted risk factors to predict the occurrence of Latent Tuberculosis Infection (LTBI) and to define prevention strategies and interventions. Methods This is a cross-sectional ambispective observational study without drug and device. The primary endpoint is the prevalence of LTBI. The secondary endpoint is the identification of possible risk factors of LTBI in a large cohort of HCWs and students. Conclusions This study aims to enrich the primary prevention measures against TB, having a high socio-economic-health impact in high-risk populations (HCWs and students) through an interoperable digital approach based on data obtained in three large Italian teaching hospitals. ClinicalTrials.gov: NCT05756582
Article Details
Authors (32)
Angela Rizzi
Eleonora Nucera
Walter Mazzucco
Pierpaolo Palumbo
Domenico Staiti
Umberto Moscato
Francesco Maria De Simone
Michela Sali
Luca Boldrini
Nikola Dino Capocchiano
Stefano Patarnello
Gabriele Rumi
Raffaella Chini
Valentina Carusi
Michele Centrone
Alessia Di Rienzo
David Longhino
Chiara Laface
Sabato Mellone
Carmelo Massimo Maida
Emanuele Cannizzaro
Luigi Cirrincione
Maria Gabriella Verso
Annalisa Saracino
Francesco Di Gennaro
Luigi Vimercati
Luigi De Maria
Stefania Sponselli
Giancarlo Scoppettuolo
Roberta Pastorino
Antonio Gasbarrini
Riccardo Inchingolo