PLoS ONE
Articles in this Issue
Comparison of traditional systemic analgesic, single shot or continuous fascia iliaca compartment block for pain management in patients with hip or proximal femoral fractures: A protocol for systematic review and network meta-analysis
Introduction Pain management for hip and proximal femoral fractures includes oral and parenteral opioids and various regional anesthesia techniques. Fascia iliaca compartment blocks (FICB) are commonl...
Beyond the Greater Angkor Region: Automatic large-scale mapping of Angkorian-period reservoirs in satellite imagery using deep learning
Archaeologists often use high-resolution satellite imagery to identify potential archaeological sites or features, including ancient settlements, burial mounds, roads, and even subtle differences in v...
Physical activity and handgrip strength in patients with mild, moderate and severe haemophilia: Impacts on bone quality and lean mass
Background Patients with haemophilia (PwH) might be restricted in physical activity (PA) depending on the severity phenotype. It is well-known that PA affects overall health including bone quality. Th...
Psychophysiological correlates of science communicators
We conducted a study in an ecological setting to evaluate the heart rate variability (HRV) of expert communicators during a live national primetime video interview. The study involved 32 expert scienc...
Association of ambient air pollution exposure with psychological distress in mid and later adulthood: A 26-year prospective cohort study
Background Existing evidence on associations between exposure to air pollution and psychological distress from middle to older age is limited by consideration of short exposure periods, poor historic...
CRISPR/dCas12a-mediated activation of SlPAL2 enhances tomato resistance against bacterial canker disease
Crop protection is essential for maintaining and improving agricultural productivity. While pesticides are commonly used to control pests, they pose several challenges, including environmental harm an...
Assessing least-cost mitigation methods for environmental phosphorus loading of different pasture-based and housed dairy production systems in Great Britain
Mitigating environmental phosphorus loading (EPL) from dairy farms reduces water pollution and improves the sustainability of production. Studies generally simulate EPL from dairy farms using a repres...
Identification of cross-reactive vaccine antigen candidates in Gram-positive ESKAPE pathogens through subtractive proteome analysis using opsonic sera
The Gram-positive pathogens of the ESKAPE group, Enterococcus faecium, and Staphylococcus aureus , are well-known to pos...
Prevalence and antimicrobial susceptibility pattern of gram-negative bacteria contaminating the hands of patients’ visitors at regional referral hospitals in Dar-es-Salaam
Background Hand contamination by bacteria is a significant source of infection transmission, especially in hospital settings. A healthcare-associated infection is one that a person contracts as a resu...
Level of overweight and obesity surpassed underweight among women in 40 low and middle-income countries: Findings from a multilevel multinomial analysis of population survey data
Background Despite continued global and local initiatives to address nutritional problems, low- and middle-income countries are facing both malnutrition and non-communicable diseases, with about 80% o...
Deep phenotyping to understand hearing and hearing disorders: Protocol for a feasibility study
Globally, hearing loss affects around 1.5 billion people, while tinnitus is estimated to impact around 740 million. More research is urgently needed to address the challenges presented by hearing loss...
Accurate disaster entity recognition based on contextual embeddings in self-attentive BiLSTM-CRF
Automated extraction of disaster-related named entities is crucial for gathering pertinent information during natural or human-made crises. Timely and reliable data is vital for effective disaster man...
Behaviour-based movement cut-off points in 3-year old children comparing wrist- with hip-worn actigraphs MW8 and GT3X
Background Behaviour-based physical intensity evaluation requires rigorous calibration before application in long-term recordings of children’s sleep/activity patterns. This study...
Effects of sleeve gastrectomy and Roux-en-Y gastric bypass on the pharmacokinetics of gabapentin and pregabalin: A cohort study
Background Bariatric surgery may affect the pharmacokinetics of medications by altering the gastrointestinal physiology. Pharmacokinetic changes of first-line neuropathic pain medications such as gab...
Exploring the link between work-related psychosocial factors and professional quality of life among ethiopian healthcare workers: Insights from structural equation modelling analyses
Background Work-related psychosocial factors increase the likelihood of poor professional quality of life (PQoL) outcomes, which are composed of three subscales burnout (BO), compassion fatigue(CF), a...
37-Day microgravity exposure in 16-Week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites
Exposure to weightlessness in microgravity and elevated space radiation are associated with rapid bone loss in mammals, but questions remain about their mechanisms of action and relative importance. I...
Healthcare-seeking behaviors and factors influencing non-adherence among cervical cancer patients attending Bugando Oncology Clinic in Mwanza, Tanzania: A qualitative Phenomenological study
Background In low- and middle-income countries, particularly in Tanzania, most patients with cervical cancer present with advanced-stage disease and exhibit non-adherence which results in increased n...
The effect of nuciferine on the renal dysfunction following ischemia-reperfusion injury
Renal ischemia-reperfusion injury (IRI) is an inevitable consequence of several clinical conditions and surgical procedures including renal transplantation and resuscitation following systemic hypoten...
Omega-3 attenuates the severity of medication-related osteonecrosis of the jaws in rats treated with zoledronate
This study aimed to evaluate the ability of ω-3 to modulate the tissue response in rats with MRONJ, focusing on histopathological and immunohistochemical parameters. Forty Wistar rats were subjected t...
The effect of time-of-day on short-term repetitive maximal performance, cognitive ability and psychological variables in adolescents
Previous studies investigating the diurnal variation of physiological and psychological variables during exercise have yielded conflicting results. The present investigation was designed to assess the...
Self-efficacy, self-esteem, and happiness in older adults: A cross-sectional study
Background Happiness is crucial for well-being in older people, but it can be challenged by various health issues. While previous research has explored individual predictors of happiness, there is li...
In vitro experiments and network pharmacology-based investigation of the molecular mechanism of neferine in the treatment of gastric cancer
Background Gastric cancer is the world’s leading tumor disease in terms of morbidity and mortality and is currently treated clinically with a comprehensive approach based on surgery. Studies have demo...
Ethnic variations in cardiovascular disease (CVD) risk factors and associations with prevalent CVD and CVD mortality in the United States
Objective To explore the association between ethnicity and cardiovascular disease (CVD) risk factors, including physical inactivity, obesity, hypertension, type 2 diabetes (T2D), lack of health insura...
PUNCH2: Explore the strategy for intrinsically disordered protein predictor
Intrinsically disordered proteins (IDPs) and their intrinsically disordered regions (IDRs) lack stable three-dimensional structures, posing significant challenges for computational prediction. This st...
Mobilizing community health assets through intersectoral collaboration for social connection: Associations with social support and well-being in a nationwide population-based study in Catalonia
Background Limited social connection among older adults poses a global public health challenge, reducing sources of support and affecting health and well-being. National public health strategies that...