PLoS ONE
Articles in this Issue
Animal models in preclinical metastatic breast cancer immunotherapy research: A systematic review and meta-analysis of efficacy outcomes
Breast cancer, particularly metastatic breast cancer (MBC), presents aggressive clinical challenges with limited treatment success. Immunotherapy has emerged as a promising approach, however, discrepa...
The plant matrix of Artemisia annua L. for the treatment of malaria: Pharmacodynamic and pharmacokinetic studies
Artemisinin-based combination therapies (ACTs) constitute the principal strategy for combating malaria in contemporary times, and research into the multifaceted components of Artemisia annua L. (A. an...
In-depth investigation of genome to refine QTL positions for spontaneous sex-reversal in XX rainbow trout
Sex determination is a flexible process in fish, controlled by genetics or environmental factors or a combination of both depending on the species. Revealing the underlying molecular mechanisms may ha...
‘It’s not just immoral!’: The role of moral disengagement and incivility in dehumanising the transgressor of immoral behaviour
People who engage in immoral behaviour are often dehumanised. However, they also tend to justify their actions to convince themselves or others that their misconduct is morally acceptable. In this pap...
A new early actinopterygian from the Mid-Pennsylvanian Logan Quarry Shale member of Indiana
Kalops is a genus of early ray-finned fish in North America. It is distinguished from early actinopterygians by the combination of the following characters: subterminal mouth, rounded oval shaped lacr...
AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease models
Biallelic mutations in the glucosylceramidase beta 1 (GBA1) gene are the underlying genetic cause of Gaucher’s disease (GD), resulting in a deficient lysosomal hydrolase and subsequent accumulation of...
Retraction: Multiliteracies meet new methods: The case for digital writing in English education case study in G-7 countries
Prognostic and predictive value of IDO expression in metastatic melanoma treated with Ipilimumab
Background The tumor microenvironment is crucial for prognosis and response to immunotherapy in several tumor entities. Methods In a multicenter retrospective study, a total of 86 tumor samples from...
A contemporary tool for assessing instrumental activities of daily living: Validation of a caregiver-reported scale for non-institutionalized older adults
Background Instrumental activities of daily living (IADL) refer to activities necessary for independent living, emphasizing community-related tasks. The literature has limited measurement tools that a...
3000 yr-old patterns of mobile pastoralism revealed by multiple isotopes and radiocarbon dating of ancient horses from the Mongolian Altai
Pastoral nomadism is of great cultural and economic importance in several regions of the world today. However, documenting ancient patterns of mobility in societies where pastoralism was central is ch...
Socioeconomic inequalities in Chile during the COVID-19 pandemic: A regional analysis of income poverty
The COVID-19 pandemic caused an unprecedented economic crisis, intensifying poverty levels in Latin America, particularly in Chile. This study examines the short- and long-term socioeconomic impacts o...
Gender differences in the impact of fatigue on lower limb landing biomechanics and their association with anterior cruciate ligament (ACL) injuries: A systematic review and meta-analysis
Background This meta-analysis examines the impact of neuromuscular fatigue on gender differences in lower limb landing biomechanics and its correlation with ACL injury risk. Methods A comprehensive...
Evaluation approach of prefabricated components based on multi-layer complex network model combined with improved topsis method
Prefabricated buildings face greater and different prefabricated components throughout their entire lifecycle, leading to a significant increase in management difficulty. This article proposes an eval...
Retraction: COVID-19 pandemic and unemployment rate prediction for developing countries of Asia: A hybrid approach
Exploration of combined factors related to quality of life after knee replacement surgery
In this study, we aimed to identify combined factors associated with lower postoperative quality of life (QOL) in knee replacement (KR) patients, utilising data from the Osteoarthritis Initiative (OAI...
Did he or didn’t he? Mixed evidence for the continued influence of retracted misinformation on person impressions
Retracted misinformation often continues to influence event-related reasoning, but there is mixed evidence that it influences person impressions. A recent study found no evidence for the continued inf...
Application of artificial intelligence in X-ray imaging analysis for knee arthroplasty: A systematic review
Background Artificial intelligence (AI) is a promising and powerful technology with increasing use in orthopedics. The global morbidity of knee arthroplasty is expanding. This study investigated the u...
Effect of timed exercise interventions on patient-reported outcome measures: A systematic review
Background Exercising at a specific time of day has the potential to mitigate the negative effects of disrupted circadian rhythms caused by irregular work and sleep schedules on the development of chr...
Multifaceted investigations of PSMB8 provides insights into prognostic prediction and immunological target in thyroid carcinoma
The Proteasome 20S subunit beta 8 (PSMB8) is an integral element of the immunoproteasome complex, playing a pivotal role in antigen processing. Despite its significance, the contributory role of PSMB8...
Disability services in higher education: Statistical disparities and the potential role of AI in bridging institutional gaps
Disparities in disability services between two-year and four-year higher education institutions pose challenges to achieving equitable access to accommodations. This study applies a robust quantitativ...
Exploring the impact of a personalised disability reform on people with disability and their primary carers: Evidence from the Australian national disability insurance scheme
Australia introduced the National Disability Insurance Scheme (NDIS) in 2013 to provide personalised formal care to individuals under 65 with significant and likely permanent disability. However, many...
The F-words relating to symptomatic flexible flat feet: A scoping review
Flexible flat feet are one of the most common musculoskeletal concerns presenting to paediatric health services, despite this being an expected finding in children under 10 years and only requiring ma...
WTools: A MATLAB-based toolbox for time-frequency analysis of infant data
Electroencephalography (EEG) is an established method for investigating neurocognitive functions during human development. In cognitive neuroscience, time-frequency analysis of the EEG is a widely use...
Evaluating the effects of e-health interventions on mental health outcomes in individuals with breast cancer: A systematic review
Individuals with breast cancer (BC) often experience significant psychological distress throughout their cancer journey, and while e-health interventions show promise, evidence of their effectiveness...
Exploring barriers and facilitators in implementation fidelity of malaria screening intervention at Nepal-India border point-of-entry health desks-A mixed method study
Purpose This research aimed to identify the barriers and facilitators in implementation fidelity of malaria screening at Nepal-India border Point of Entry (POE) health desks. Method A mixed-method a...