PLoS ONE
Articles in this Issue
Mental health and health-related quality of life among adults with osteoarthritis: A national population-based study
Background Adults with osteoarthritis are vulnerable to mental health disorders, which may have a significant impact on their Health-Related Quality of Life (HRQoL). Thus, the purpose of this study wa...
AKR1C2 silencing promotes ferroptosis and inhibits proliferation, migration, and invasion in lung cancer cells
Background Lung cancer is the leading cause of cancer-related deaths worldwide, so research and development of potential therapeutic targets is urgent. Methods The target gene, AKR1C2, was screened...
Differences in hair coat condition between female and male mice occur through testicular-derived factors and are affected by the presence of another mouse
An animal’s coat protects its body from ultraviolet rays, physical and chemical damage, and temperature changes. It also plays an important role in showing individual information like a pattern for th...
Research on learning achievement classification based on machine learning
Academic achievement is an important index to measure the quality of education and students’ learning outcomes. Reasonable and accurate prediction of academic achievement can help improve teachers’ ed...
Group antenatal care positively transforms the care experience: Results of an effectiveness trial in Malawi
Background We developed and tested a Centering-based group antenatal (ANC) model in Malawi, integrating health promotion for HIV prevention and mental health. We present effectiven...
Effect of retinoic acid treatment on the retinoic acid signaling pathway in a human siRNA-based aniridia limbal epithelial cell model, in vitro
Purpose In the present study, we evaluate gene and protein expression levels in an in vitro siRNA-mediated PAX6 knockdown limbal epithelial cell (LEC) model after RA treatment. This study aims to inve...
Suicidal ideation and non-fatal suicidal self-directed violence prevalence and associations among Veterans residing in U.S. Pacific Island Territories: Guam, American Samoa, and the Northern Mariana Islands
Suicide rates are high in United States (U.S.) Pacific Island Territories, where large numbers of Veterans reside. Yet knowledge of suicidal self-directed violence (SSDV) among Veterans in this region...
Editorial Note: Depressive symptoms and associated factors among HIV positive patients attending public health facilities of Dessie town: A cross-sectional study
The effect of photoperiod, environmental temperature and wind speed on external quality of free-range turkey eggs
Due to the lack of research in free-range poultry, the influence of environmental factors on laying remains underdeveloped nowadays. Therefore, the present study aimed to determine the influence of me...
Bridging self-directed learning and competency in interdisciplinary teaching among STEM lecturers: How psychological capital connects
University STEM education is vital for cultivating innovative talents but is hindered by a lack of lecturers skilled in interdisciplinary teaching. Research on the interplay between psychological capi...
Evaluating the readability, quality, and reliability of responses generated by ChatGPT, Gemini, and Perplexity on the most commonly asked questions about Ankylosing spondylitis
Ankylosing spondylitis (AS), which usually occurs in the second and third decades of life, is associated with chronic pain, limitation of mobility, and severe decreases in quality of life. This study...
Development of cookies from wheat-yellow/white maize composite blends and their physical and sensory evaluation
Wheat is a staple food in many countries globally, but it alone cannot meet the dietary demands of the growing population. To address this, there is an increasingly critical need to integrate alternat...
The influence of women’s groups mobilisation on health emergency response: Evidence from the Ebola outbreak in Liberia
Background The 2014–2016 Ebola outbreak in West Africa showed that multiple response strategies are necessary to contain disease outbreaks in resource-constrained settings. A critical component of the...
Estimating abundance of harvested populations at the management unit scale
Management of harvested populations relies on accurate assessment of abundance within management units to reevaluate and set harvest regulations. Several statistical approaches use readily available a...
Factorial structure of the patient health questionnaire-9, generalized anxiety disorder-7 and berger HIV stigma scale-short form among adolescents living with HIV in Ghana
Background Mental health issues and stigma experiences significantly affect adolescents living with HIV (ALHIV). While the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7...
A genome-wide SNP-SNP interaction analysis exploring novel interacting loci associated with the risk of recurrence in colorectal cancer
Background Genetic factors can influence and predict patient outcomes. The association of interactions of germline SNPs with patient outcomes is an understudied area of prognostic research. In this st...
Verification of emerging genomic mutations in Mycobacterium tuberculosis allows transmission chains to be distinguished in an epidemiological typing cluster extending over thirty years
Whole genome sequencing (WGS) is able to identify epidemiological links between Mycobacterium tuberculosis isolates. Recent clustering can be ruled out using a...
Aging dimensions and markers as relative predictors of mortality in a longitudinal epidemiological sample
Measurement of aging is critical to understanding its causes and developing interventions, but little consensus exists on what components such measurements should include or how they perform in predic...
Does geopolitical risks drive the extreme spillovers of bulk energy and chemical commodity
Geopolitical risks (GPR) can affect the prices of natural resources, which are crucial for survival and sustainable economies. Based on the TVP-VAR-BK models, this paper examines the asymmetric risk c...
Investigating the effect of butanol isomers on combustion and emissions in port injection dual fuel diesel engines: an experimental study
The present study examines the effects of substituting alternative fuels for diesel fuel and employing a dual fuel approach on diesel engine combustion characteristics and emissions. Various butanol i...
Association between the Body Roundness Index and osteoarthritis: A population-based study
Background Obesity is recognized as an independent risk factor for the development of osteoarthritis (OA). The Body Roundness Index (BRI) represents a novel metric for assessing obesity, yet its conne...
Long-term anti-SARS-CoV-2 antibody trajectories after neutralizing monoclonal antibody treatment
Background Neutralizing monoclonal antibodies (nMAbs) have been used to treat COVID-19 and are increasingly being used to treat other infections. However, there is concern that by neutralizing the SAR...
Tracheostomy in COVID-19: A retrospective cohort study of outcomes and mortality predictors in a specialized infectious disease hospital in Brazil
Background The COVID-19 pandemic profoundly impacted critical care practices, leading to a significantly increase in tracheostomies for patients with respiratory failure. This study aimed to investiga...
Influence of openings on the snowdrift characteristics of cubes
Snow drifts and accumulates under wind actions, leading to a complex distribution of snow around and on the surface of structures with openings, which in turn has a detrimental influence on the struct...