PLoS ONE
Articles in this Issue
Optimizing the train timetable in a high-speed rail corridor: The implications on departure time, fare cost and seat preference of passengers
High-speed railway timetables are typically based on origin-destination (OD) passenger demand, establishing departure times and intervals for trains. Utilizing this data, operators systematically deve...
A novel ABC fractional-order mathematical model for malaria transmission dynamics incorporating treatment-seeking behavior
Malaria remains a significant global health challenge, particularly in developing countries. This study introduces a novel ABC fractional-order model to analyze malaria transmission dynamics, incorpor...
Natural soap is clinically effective and less toxic and more biodegradable in aquatic organisms and human skin cells than synthetic detergents
In the era of COVID-19, concerns about and consumption of soaps and detergents have increased. The environmental effects, along with their direct impacts on the human body, are being simultaneously co...
Advancing breast cancer prediction: Comparative analysis of ML models and deep learning-based multi-model ensembles on original and synthetic datasets
Breast cancer is a significant global health concern with rising incidence and mortality rates. Current diagnostic methods face challenges, necessitating improved approaches. This study employs variou...
Relationships of corticosterone and thyroxine with mortality, mass gain, feeding and activity in Kemp’s ridley sea turtles (Lepidochelys kempii) recovering from cold-stunning
Mass strandings of juvenile Kemp’s ridley sea turtles (Lepidochelys kempii) occur annually on the shores of Cape Cod, Massachusetts, USA, during the months of Oct-Dec. Strandings have increased from d...
Editing metacaspase (StMC7) gene enhances late blight resistance in Russet Burbank potato
Plants induce hypersensitive response programmed cell death (HR-PCD), upon biotrophic pathogen infection, to contain the pathogen to the point of infection. Apoptotic-like PCD (AL-PCD) has been report...
Impact of conditional cash transfer on households food security in Akwa Ibom State, Nigeria
The Nigerian government introduced the Household Upliftment Program (HUP) which is a conditional cash transfer scheme to help households improve consumption levels, reduce poverty and therefore preven...
Some diseases are described in the literature as sometimes acute, sometimes chronic: How do general practitioners take medical decisions when faced with “fluctuating” conditions? A qualitative study
Background Although there is a clear distinction between the management of typically acute diseases (e.g., a sore throat) and the management of typically chronic diseases (e.g., diabetes), there is al...
Does the registration system reform reduce the finance sector’s risk spillover effect in China’s stock market—Causal inference based on dual machine learning
With growing uncertainty in global trade, improving access to domestic capital markets has become an important way to manage financial risk spillovers. This study examines how the registration system...
Prevalence of the depression among heart failure patients in Ethiopia, 2024: A systematic review and meta-analysis
Background Heart failure (HF) is a major clinical condition contributing to high morbidity, mortality, and healthcare burden. Depression is increasingly recognized as a nontraditional risk factor for...
The impact of historical redlining policies on community composition and the COVID-19 pandemic in Boston
The COVID-19 pandemic has accentuated racial and socioeconomic disparities that have existed in the U.S. because of structural racism. We aimed to understand how the legacy of historical redlining pol...
Correction: Exercise prescription for the prevention and treatment of chronic diseases in primary care: Protocol of the RedExAP study
The relationship between pollen monodiets and the activities of proteolytic systems in the fat body and hemolymph of honeybee workers
The homogenization of landscapes through the introduction of large-scale farms, the decline of biodiversity conditioned by high summer temperatures and dry weather, as well as the expansion of alien s...
Animal movement estimation and network-based epidemic modeling: Illustration for the swine industry in Iowa (US)
Animal movement plays a critical role in disease transmission between farms. However, in the United States, the lack of available animal shipment data, sometimes coupled with a lack of detailed inform...
Correction: Psychological distress during the COVID-19 pandemic in Canada
A comparative systematic review and meta-analysis of uterine artery resistance in pregnant women with and without previous history of cesarean section
Background Increased uterine artery resistance in pregnant women with a history of cesarean section has been suggested to contribute to adverse pregnancy outcomes. However, the literature presents con...
Cell-mechanical parameter estimation from 1D cell trajectories using simulation-based inference
Trajectories of motile cells represent a rich source of data that provide insights into the mechanisms of cell migration via mathematical modeling and statistical analysis. However, mechanistic models...
A study protocol for a pragmatic pre-post trial to determine the feasibility and effectiveness of a novel co-designed service to support health and wellbeing of older carers of older people
Older carers (≥50 years) of older people (≥65 years) are an important sub-group of carers performing valuable roles in providing informal care but often do not have the time or give priority to suppor...
Correction: Close to the border—Resilience in healthcare in a European border region: Findings of a needs analysis
Enhancing stock timing predictions based on multimodal architecture: Leveraging large language models (LLMs) for text quality improvement
This study aims to enhance stock timing predictions by leveraging large language models (LLMs), specifically GPT-4, to filter and analyze online investor comment data. Recognizing challenges such as v...
Vicarious post-traumatic growth in Chinese oncology nurses: A cross-sectional study
In the traditional Chinese culture, vicarious trauma poses a significant threat to oncology nurses who are frequently exposed to death and illness. This exposure can undermine both the physical and me...
Impact of serum phosphate levels during CRRT on extubation failure and hospital mortality in mechanically ventilated ICU patients—A study based on the MIMIC-IV database
Background Electrolyte imbalances, particularly phosphate depletion, are prevalent yet often underestimated complications in the Intensive Care Unit (ICU), notably among patients undergoing Continuous...
Diagnoses and critical care outcomes in a rural Tanzanian high dependency unit: A prospective cohort study
Background Data on rural sub-Saharan African high-dependency units (HDU) are lacking. We describe patient’s characteristics, diagnoses, and outcomes of patients admitted to a Tanzanian HDU, and identi...
Identifying determinants for promoting public engagement via Chinese E-government TikTok in public health emergencies
Background Social media have become vital tools for governments during public health crises, enabling the timely dissemination of critical information, health guidance, and public engagement. In China...
“...In Kiambu county, there are different things being done”: A qualitative exploration of healthcare workers’ experiences with cord care practices
Introduction Neonatal sepsis (NNS) continues to be a leading cause of neonatal mortality in low-resource settings. NNS can occur secondary to umbilical stump infections (omphalitis) and this requires...