PLoS ONE
Articles in this Issue
Editorial Note: Fertility return after hormonal contraceptive discontinuation and associated factors among women attended Family Guidance Association of Ethiopia Dessie model clinic, Northeast Ethiopia: A cross-sectional study
“We have to amplify what we saw at EBOVAC” – Assessing participant perceptions, attitudes, and acceptability of an ancillary care policy in an Ebola vaccine trial in the Democratic Republic of the Congo: A mixed methods study
Introduction In a vaccine trial conducted between 2019 and 2022 in Boende, a remote, resource-constrained area of the Democratic Republic of the Congo, our research team developed an ancillary care (A...
Development and validation of a clinical prediction model for in-hospital heart failure risk following PCI in patients with coronary artery disease
Objective Patients with acute coronary syndrome (ACS) are at increased risk of in-hospital heart failure (HF) following percutaneous coronary intervention (PCI), yet understanding of the associated ri...
The impact of IRT and IDT on metaverse adoption in tourism: The moderating role of personal innovativeness among China’s generation Z
This study examines the Metaverse—a virtual world that merges entertainment, work, and social interactions—in terms of leisure tourism, using the frameworks of innovation resistance and diffusion theo...
Assessing the effects of design modifications on the use of wildlife exits designed for endangered Texas ocelots
Roadside exclusionary fencing is commonly used on highways to prevent wildlife-vehicle collisions. Although it can mitigate wildlife road mortality by limiting their access to the road, it can also cr...
Pretreatment expression of miR-191a may predict response to the induction chemotherapy based on cytarabine in acute myeloid leukemia patients – a single-center pilotal study
Background Acute myeloid leukemia (AML) is associated with the accumulation of acquired genetic disorders. Moreorver chromosomal and molecular changes are independent prognostic factors that are taken...
Diagnosis of knee meniscal injuries using artificial intelligence: A systematic review and meta-analysis of diagnostic performance
Aim of the study The aim was to systematically review the literature and perform a meta-analysis to estimate the performance of artificial intelligence (AI) algorithms in detecting meniscal injuries....
Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort
Objective Knee osteoarthritis (OA) is a heterogeneous disease with different endotypes and phenotypes, resulting in patients’ varying clinical and structural progression. Several genomic markers have...
MVT-Net: A novel cervical tumour segmentation using multi-view feature transfer learning
Cervical cancer is one of the most aggressive malignant tumours of the reproductive system, posing a significant global threat to women’s health. Accurately segmenting cervical tumours in MR images re...
Characterization of the Pank2-/- mouse retinal phenotype as a pre-clinical model for pantothenate kinase-associated neurodegeneration
Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive movement and vision disorder in the neurodegeneration with brain iron accumulation family of diseases. PKAN is caused...
Genetic profiling of inherited colorectal cancer syndromes in Tunisian patients
Objective Colorectal cancer (CRC) is among the most commonly diagnosed cancers worldwide, with 2% to 5% of cases being linked to inherited syndromes. Material and methods A cohort of 30 Tunisian pat...
Predicting podoplanin expression and prognostic significance in high-grade glioma based on TCGA TCIA radiomics
Background Podoplanin (PDPN) is a membrane glycoprotein implicated in tumor invasion and immune modulation in high-grade gliomas (HGGs). However, the non-invasive prediction of PDPN expression and its...
Estimation of the future prevalence of diabetes based on data from the Brazilian Study of Cardiovascular Risk Factors in Adolescents (ERICA)
Introduction Diabetes is a significant public health issue due to its high prevalence and multifaceted consequences, impacting both the Brazilian Unified Health System and society. The disease adverse...
Evaluation of the prevalence of MASLD, MASH and liver fibrosis in a Dutch bariatric cohort
Background and aims The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) in bariatric populations has been wid...
Determinants of cervical cancer screening utilisation among women in the least developed countries: A systematic review and meta-analysis
Background and aims Globally, cervical cancer is the fourth most common cancer among women, and more than 90% of all cervical cancer-related deaths worldwide are recorded in resource-limited countries...
New approach to the development of tailor-made feed for fish larvae using Zebrafish Danio rerio as a model
Protein hydrolysates have been used extensively as dietary protein for larval fish. Typically, they are expensive, difficult to produce, and show varying results when utilized for different species. T...
Computational design and cheminformatics profiling of omeprazole derivatives for enhanced proton pump inhibition of potassium-transporting ATPase alpha chain 1
Proton pump inhibitors are essential for treating moderate-to-severe gastroesophageal reflux, peptic ulcers, esophagitis, and related conditions by increasing gastric pH and inhibiting hydrogen ion di...
Design and experiment of spiral conveying pipe in pneumatic centralized fertilizer discharge system
To address the problem of poor fertilizer uniformity caused by vibration and skewing during rice transplanter operations, this study developed a pneumatic centralized spiral fertilizer discharge syste...
Correction: Investigating the association between diabetes and carpal tunnel syndrome: A systematic review and meta-analysis approach
Does urban density always boost smart productivity? Evidence of an inverted U-shaped relationship in Chinese cities
Does urban density always boost smart productivity? Based on panel data from 28 major Chinese cities (2011–2021), this study reveals an inverted U-shaped relationship between urban density and smart p...
Hyperuricemia and associated factors among adult cardiovascular disease patients at Salale University Comprehensive Specialized Hospital, Fitche, Central Ethiopia
Background Despite evidence suggesting that hyperuricemia (serum uric acid >7.0 mg/dL in males and >6.0 mg/dL in females) contributes to adverse outcomes like mortality and hospitalization in pa...
Heart failure treatment patterns: A pharmacoepidemiological descriptive study in Colombia (The HEATCO study)
Introduction Heart failure is a common condition associated with significant mortality. Objective: to determine the prescription patterns of medications for the treatment of heart failure in a cohort...
Organizational barriers in HPV vaccination uptake: A cross-sectional study among health sciences students
Background Human papillomavirus (HPV) is a leading cause of cervical, anal, and oropharyngeal cancers. Despite the proven effectiveness of HPV vaccination, uptake remains low, particularly among males...
Feasibility and acceptability of GeneXpert MTB/XDR implementation among healthcare workers in three low-middle income African countries
Background Xpert MTB/XDR (Xpert-XDR) testing can significantly shorten time to initiating appropriate drug-resistant tuberculosis (DR-TB) treatment, but its introduction may impact laboratory workflow...
Rethinking HIV care for youth: Insights from qualitative research with youth in Chad
Youth ages 15–24 years are significantly impacted by the HIV/AIDS epidemic, representing approximately 37% of new infections globally. This demographic is especially vulnerable in sub-Saharan Africa,...