PLoS ONE
Articles in this Issue
Using an e-Delphi consensus technique to develop the Stressful Adverse Veterinary Events Support (SAVES) Framework
Co-ordinated approaches to supporting veterinary practitioners in relation to adverse events are needed to mitigate associated practitioner stress and to prevent future occurrence. The overarching aim...
Cross-field strength and multi-vendor reliability of MagDensity for MRI-based quantitative breast density analysis
Purpose Breast density (BD) is a significant risk factor for breast cancer, yet current assessment methods lack automation, quantification, and cross-platform consistency. This study aims to evaluate...
Effect of health education intervention on treatment adherence and health status in patients with Chronic obstruction pulmonary disease: A random control trial
Adherence to treatment is critical to effective management of COPD and is key to addressing the growing burden of disease. So, this study conducted to evaluate the effectiveness of a health education...
Comparison of systemic immunoinflammatory biomarkers for assessing severe abdominal aortic calcification among US adults aged≥40 years: A cross-sectional analysis from NHANES
Objective Several novel biomarkers, including the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), aggregate index of systemic inflammation (AISI), platelet-lymph...
Prevalence of vision impairment among patients with diabetes mellitus in sub-Saharan Africa: A systematic review and meta-analysis
Background Diabetes mellitus is a growing global public health challenge, especially in low- and middle-income regions like sub-Saharan Africa, where healthcare resources are often limited. One of its...
Shear wave velocity prediction using Long Short-Term Memory Network with generative adversarial mechanism
Shear wave velocity (Vs) serves as a crucial petrophysical parameter for subsurface characterization, yet its acquisition remains challenging. While long short-term memory (LSTM) networks have emerged...
Sex-specific effects of appetite suppressants on stereotypy in rats
This study investigated the sex-specific effects of commonly prescribed appetite suppressants on body weight and the manifestation of motor side effects, specifically stereotypy. Employing video recor...
KU60019 inhibits ovarian cancer progression by targeting DGAT1/has-miR-1273g-3p axis
Ataxia telangiectasia mutated (ATM) blockage can induce apoptosis in ovarian cancer. However, the molecular mechanisms underlying this process remain poorly understood. In this study, ovarian cancer c...
Assessment of a multiplex arbovirus PCR Detection Test in an area endemic for Chikungunya, Zika, and Dengue viruses: An evaluation of kit performance characteristics in line with Clinical Laboratory Improvement Amendments (CLIA) Standards
Introduction Several multiplex and singleplex PCR systems exist for the detection of Dengue(DENV), Zika(ZIKV), and Chikungunya(CHIKV) viruses; however, their performance characteristics in East Africa...
Maternal deaths before and during COVID-19 pandemic: Causes and avoidable factors in a tertiary hospital in South Africa, 2018‒2022
Aim To determine the institutional maternal mortality ratio (iMMR) and avoidable factors (AVFs) before and during the COVID-19 pandemic in a tertiary hospital in South Africa. Methods This was a ret...
Systems thinking with active implementation research (STAIR): Protocol for a school-based randomised control trial for childhood obesity prevention
Introduction This paper presents the protocol for the effectiveness-implementation trial: Systems Thinking with Active Implementation Research (STAIR) for childhood obesity prevention. STAIR’s objecti...
An integrated IKOA-CNN-BiGRU-Attention framework with SHAP explainability for high-precision debris flow hazard prediction in the Nujiang river basin, China
Debris flows represent a persistent challenge for disaster prediction in mountainous regions due to their highly nonlinear and multivariate triggering mechanisms. This study proposes an explainable de...
Identifying risks in dementia care: Insights from a qualitative study with clinical pharmacists
Introduction People with dementia experience complex healthcare needs. Clinical pharmacists play a crucial role in optimising medication management and ensuring patient safety within the primary care...
Ediacaran-Cambrian paleosols of Nevada and California
The Cambrian and Ediacaran sequence of California and Nevada is rife with unconformities, paleovalleys, paleosols, and fluvial facies. This study confirms shallow marine environments for grey stromato...
Recognition of common shortwave protocols and their subcarrier modulations based on multi-scale convolutional GRU
Shortwave communication plays a vital role in disaster relief and remote communications due to its long-range capabilities and resilience to interference. However, challenges such as multipath propaga...
The impact of experimental designs & system sloppiness on the personalisation process: A cardiovascular perspective
To employ a reduced-order cardiovascular model as a digital twin for personalised medicine, it is essential to understand how uncertainties in the model’s input parameters affect its outputs. The aim...
Adolescent awareness and experience of the pubertal changes: A qualitative study from Rwanda
Introduction The transition from puberty to adolescence involves significant body changes that manifest differently across young children. It is essential that adolescents become aware of these change...
Text intelligent correction in English translation: A study on integrating models with dependency attention mechanism
Improving translation quality and efficiency is one of the key challenges in the field of Natural Language Processing (NLP). This study proposes an enhanced model based on Bidirectional Encoder Repres...
Prioritizing challenges in AI adoption for the legal domain: A systematic review and expert-driven AHP analysis
This research explores the crucial challenges influencing the adoption of Artificial Intelligence (AI) in the legal domain, a field facing escalating challenges due to rapid technological advancements...
Assessing the latest advances in bone marrow stem cell therapy for Avascular Necrosis hip: A comprehensive systematic review, meta-analysis, and meta-regression of randomized controlled trial studies
Background Avascular necrosis (AVN) of the hip is a disease characterized by vascular disruptions, where 67% of untreated cases may lead to the collapse of the femoral head. None of the current approa...
Global, regional, and national burden of meningitis among children, 1990–2021: An analysis of the global burden of disease study 2021
Background Childhood meningitis remains a serious and life-threatening infectious disease with considerable risk of long-term sequelae. This study aimed to provide a comprehensive evaluation of the gl...
Selection and appointment of presidents of medical universities in Iran: Bridging reality and ideal through global and local evidence
Background The selection of university presidents who oversee health systems within their respective provinces has become increasingly critical in Iran, subjecting to an ongoing scrutiny and debate. T...
Access and utilization of youth friendly sexual and reproductive health services among illiterate adolescents in Rwanda: A mixed-methods participatory study
Background Youth Friendly Health Services Centers (YFHS) in Rwanda have been established to address the lack of information and services related to reproductive health. However, there is a paucity of...
Evaluating the longitudinal physical and psychological health effects of persistent long Covid 3.5 years after infection
This is a 3.5-year single-center observational cohort study investigating the longitudinal impact of Long Covid on the physical and mental health of patients. Patients were assessed at 3 months, 1 yea...
Magnitude of multidrug-resistant and extended-spectrum β-lactamase-producing gram-negative bacteria from tracheal aspirates of intensive care unit patients in Ethiopia
Background Globally, multidrug-resistant (MDR) and extended-spectrum β-lactamase-producing (ESBL)Gram-negative bacterial pathogens are causing significant public health problems, particularly in inten...