PLoS ONE
Articles in this Issue
The global impact of non-alcoholic fatty liver disease (including cirrhosis) in the elderly from 1990 to 2021 and future projections of disease burden
Background Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by hepatic steatosis and inflammation in individuals with no significant alcohol consumption history. Predomin...
Computer-aided discovery of dual-target compounds for Alzheimer’s from ayurvedic medicinal plants
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline, driven by the accumulation of amyloid-beta plaques and neurofibrillary tangles. It involves the dysfunction...
Identification of novel biomarkers related to pathogenesis and treatment of psoriasis based on integrated analysis of weighted gene co-expression network analysis and LASSO
Background Psoriasis is an inflammatory skin disease, and current treatments have their own limitations, including moderate treatment effectiveness, poor compliance, and potential safety risks, etc. T...
PoseNet++: A multi-scale and optimized feature extraction network for high-precision human pose estimation
Human pose estimation (HPE) has made significant progress with deep learning; however, it still faces challenges in handling occlusions, complex poses, and complex multi-person scenarios. To address t...
Optimizing genomic diversity assessments for conservation of Bromus auleticus (Trinius ex Nees) using individual and pooled sequencing
Bromus auleticus, a valuable forage grass native to the Pampa biome, is currently undergoing genetic erosion. Therefore, it is essential to assess appropriate methodologies for developing population g...
Study protocol of group antenatal care implementation at a public women’s hospital in Brazil
The antenatal care is an important service offered to women during pregnancy that aims to guarantee the mother and fetus’s health. In Brazil, although the coverage of this service is high, the outcome...
Cooperation is not rewarded by friendship, but generous and selfish students repel each other in social networks
Humans cooperate across various contexts, despite the individual costs involved. Cooperation and prosocial behavior may persist because these costs are offset by reputation and other social benefits....
Evaluation of sugar meal administered anti-Leishmania compounds on the vectorial capacity of the vector, Lutzomyia longipalpis
Multiple strategies involving the parasite-host-vector triad are necessary to control leishmaniasis. One option is to prevent or reduce transmission of the pathogen by the phlebotomine sand fly vector...
Validation and adaptation of a Turkish version of the dietarian identity questionnaire
Dietarian identity reflects an individual’s cognitive, emotional, and behavioral orientation toward the consumption or avoidance of animal-based foods, including red meat, poultry, fish, eggs, and dai...
Establishment of Cre/LoxP-mediated multifunctional reporter knock-in rats with the CRISPR system
Rats and mice are essential experimental animals in preclinical research, serving as models for various human diseases and contributing significantly to drug development. Rats offer distinct advantage...
Does nematic order allow groups of elongated cells to sense electric fields better?
Collective response to external directional cues like electric fields helps guide tissue development, regeneration, and wound healing. In this study we focus on the impact of anisotropy in cell shape...
Confidence in elections among U.S. local officials: Effects of social trust, partisanship and political ambition
The U.S. public’s confidence in elections is intensively studied in the last decade but little is known about election confidence among locally elected officials, whose roles and community status may...
Boomerang and bones: Refining the chronology of the Early Upper Paleolithic at Obłazowa Cave, Poland
Beginning with the Early Aurignacian, Homo sapiens demonstrated an enhanced symbolic capacity, expanding artistic expressions from body decoration to portable art and aesthetically refined tools. Thes...
Association of microtubule destabilization with platelet yields in terminally differentiating hiPSC-derived megakaryocyte lines
Millions of platelet units are needed each year to manage thrombocytopenia and other conditions linked to excessive bleeding. These life-saving treatments still depend entirely on donated platelets, d...
Altiplano agricultural origins was a process of economic resilience, not hardship: Isotope chemistry, zooarchaeology, and archaeobotany in the Titicaca Basin, 5.5-3.0 ka
Prevailing models of agricultural origins tend to envision that economic hardship drove the transition from foraging to farming economies. Growing human populations and the depletion of high-ranked an...
How does mindfulness training affect attention and penalty kick performance in university football player
Athletes often struggle to maintain attentional focus and performance consistency under pressure, particularly during high-stakes tasks like penalty kicks. This study examined the effects of brief min...
Assessment of testicular self-examination awareness and practice among adult males in Ajman, United Arab Emirates: A cross-sectional study
Introduction Testicular cancer (TC) is one of the most common cancers affecting men between the ages of 15 and 40 years. Testicular self-examination (TSE) is an effective tool for the early detection...
Seasonal and periodic patterns of PM2.5 in Manhattan using the variable bandpass periodic block bootstrap
Air quality is a critical component of environmental health. Monitoring and analysis of particulate matter with a diameter of 2.5 micrometers or smaller (PM2.5) plays a pivotal role in understanding a...
Gender differences in trunk appearance perception and health-related quality of life (HRQoL) in the patients with moderate adolescent idiopathic scoliosis (AIS) undergoing orthotic treatment: An observational study
Background Orthotic treatment is commonly used as a non-surgical intervention for managing moderate adolescent idiopathic scoliosis (AIS). Although prior studies have evaluated various factors influen...
Crossing chasms: A PLS approach to EU public sector performance assessment
This paper examines the dynamics of public sector performance across European Union (EU) countries through a comprehensive methodological framework. This study introduces the European Public Sector Pe...
Experiences of Indigenous and ethnic minority women with culturally safe healthcare in Europe: A scoping review
Worldwide, Indigenous and ethnic minority women encounter discrimination in access to high quality healthcare and other advantageous social determinants of health. Cultural safety is the concept of pr...
Efficient preconditioning strategies for accelerating GMRES in block-structured nonlinear systems for image deblurring
We propose an efficient preconditioning strategy to accelerate the convergence of Krylov subspace methods, specifically for solving complex nonlinear systems with a block five-by-five structure, commo...
Validating self-administration as an agile modality for high-frequency diet quality data collection
Data collection of diet quality is important to estimate global dietary transitions affecting public health. Mobile-phone based tools can provide a low-cost and rapidly deployable modality to compleme...
Elucidating the functions of gut microbiota from two edible dung beetle species: Implications for waste management and food industry
Dung beetle larvae are consumed globally, yet their gut microbiota across different geographical locations remains largely unexplored. This study examined the diversity and composition of the gut micr...
Land use and climate change-based multi-scenario simulation of ecosystem service trade-offs/synergies: A case study of the central Yunnan urban agglomeration, China
Exploring Land use and climate change-based multi-scenario simulation of ecosystem service trade-offs/synergies is of great importance to regional ecological security and sustainable development. Taki...