PLoS ONE
Articles in this Issue
Potential role of proprietary patent medicine vendors in primary eye and ear care: A mixed methods study in northern Nigeria
Background In Nigeria, patent and proprietary medicine vendors (PPMVs) are permitted to sell a limited range of medication. They are important providers of health care despite their limitations and ma...
Unified solution of non-limit active and passive earth pressure of retaining wall considering soil arching effect
The existing theory can not get the unified solution of non-limit active and passive earth pressure with clear mechanical concept. Based on Duncan-Chang stress-strain model, this paper puts forward a...
Systematic review of generative adversarial networks (GANs) in cell microscopy: Trends, practices, and impact on image augmentation
Cell microscopy is the main tool that allows researchers to study microorganisms and plays a key role in observing and understanding the morphology, interactions, and development of microorganisms. Ho...
Assessment of the prognostic value of CA125 for miscarriage risk in patients with threatened abortion: A systematic review and meta-analysis
Background Threatened abortion is a common obstetric complication where early risk stratification is crucial for clinical management. CA125, a glycoprotein biomarker produced by endometrial and tropho...
Patient acceptability of CITOBOT for cervical cancer screening: A mixed-method study
This study assessed the acceptability of CITOBOT, a device for early cervical cancer screening in a real-world pilot setting as part of a translational research project aimed at designing and clinical...
Low-salinity medium for large-scale biomass production of the marine purple photosynthetic bacterium Rhodovulum sulfidophilum
Marine purple non-sulfur bacteria such as Rhodovulum sulfidophilum are versatile due to their diverse applications in bioremediation, biotechnological productio...
Protein landscape of the brush border membrane of first instar larvae of Frankliniella occidentalis, the western flower thrips
We investigated the protein composition of the brush border membrane of larval Frankliniella occidentalis (western flower thrips), an agriculturally significant crop pest and vector of plant pathogens...
Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study
Background Tuberculosis (TB) substantially compromises health-related quality of life (HRQoL), yet limited studies have assessed its impact on Ethiopian patients using the EQ-5D instrument. This study...
In planta complementation of the betalain biosynthetic pathway with a bacterial dioxygenase
Betalains are pigments naturally produced by plants belonging to the order Caryophyllales. However, 4,5-L-DOPA-extradiol-dioxygenase (DODA), the main enzyme in their biosynthetic pathway, has also bee...
Eating in the absence of hunger is not associated with weight, self-reported eating behaviors, or well-being in pregnant adults: Prospective cohort study
Objective Eating in the absence of hunger (EAH) refers to consuming food after reaching satiation and is considered a risk factor for weight gain. This study examined relations of EAH with pregnancy-r...
Attentional biases, as measured by motion-induced blindness, are linked to schizophrenia traits
Typically, people demonstrate a small attentional bias towards the left visual field. This bias has not consistently been observed in schizophrenia. Schizophrenia has been thought to be linked to a to...
A comprehensive mapping of stress system interactions with pain and their contribution to chronification of musculoskeletal pain: Protocol of the STRAIN study
Background Stress is suggested to be an important factor contributing to the development and persistence of musculoskeletal pain. Although stress and pain interactions are well known, it remains large...
Hederagenin’s uric acid-lowering effects in hyperuricemic mice: Mechanistic insights from molecular docking and in vivo analysis
This study explored the uric acid-lowering effects of hederagenin (HD) through molecular docking analysis and a chronic hyperuricemia (HUA) mouse model. Molecular docking was performed to evaluate HD’...
Exploring varicella zoster virus proteome for construction and validation of a multi-epitope based subunit vaccine using multifaceted immunoinformatics approaches
Varicella zoster (VZ) is a viral disease caused by varicella zoster virus (VZV) that is related to alphaherpesvirus subfamily. VZV causes a neurotropic disease in humans. The aim of this work was to s...
Frugal engineering of a jaw crusher using the factor-of-frugality, a modern version of the safety-factor
Businesses are increasingly keen on going frugal due to increasing demand for sustainable and low-cost products that do not sacrifice quality. However, there is a dearth of tools for the systematic de...
Probiotic bacteria vs. yeast for gastrointestinal diseases treatment: Protocol for a systematic review and meta-analysis
Background Disruption of the gut microbiota, an essential ecosystem of microorganisms inhabiting the gastrointestinal tract (GIT), has been linked to the development and progression of various gastroi...
The Healthy Brain 9 (HB9): A new instrument to characterize subjective cognitive decline, and detect anosognosia in mild cognitive impairment
Objectives Subjective cognitive decline (SCD) affects 10% of older adults and may be a risk factor for future mild cognitive impairment (MCI) and dementia. Some individuals with MC...
Future direction of digital textbooks in undergraduate nursing education: A scoping review
Digital natives have emerged, and nursing educator must develop digital textbook(DT)s the meet their information processing methods. But literature reviews on DTs remain insufficient. This scoping rev...
The in cellular and in vivo melanogenesis inhibitory activity of safflospermidines from Helianthus annuus L. bee pollen in B16F10 murine melanoma cells and zebrafish embryos
Melanin, synthesized by tyrosinase (TYR), is a natural pigment essential for skin protection and pigmentation. However, excessive melanin production can cause dermatological disorders. Safflospermidin...
Systematic mediation and interaction analyses of kidney function genetic loci in a general population study
Chronic kidney disease (CKD) is a complex disease affecting >10% of the global population, with large between- and within-continent variability reflecting major environmental determinants. To ident...
Non-invasive tape sampling of tryptophan and kynurenine in relation to phenylalanine and tyrosine from melanoma and adjacent non-lesional skin: A pilot study
Purpose To evade immunosurveillance many cancers convert tryptophan (Trp) into kynurenine (Kyn), which induces immunotolerance and suppresses immune responses. Elevated Kyn amounts have been found in...
Understanding the changes in endogenous GA3 in relation to developmental transitions in cauliflower (Brassica oleracea var. botrytis L.)
Cauliflower is a crop with intricate developmental transitions influenced by both external and internal cues. Plant growth regulators (PGRs) play a key role in developmental transitions and plant resp...
Association between serum zinc and serum neurofilament light chains: A population-based analysis
Background While serum zinc levels are strongly associated with various neurological disorders, the relationship between serum zinc and axonal damage remains largely unexplored. Consequently, the obje...
Analysis of global stock market development—Integration of clustering, classification, and shapley values
This study aims to analyze the development of global stock exchanges by integrating clustering, classification, and Shapley Values to identify growth patterns and understand the differences in market...
Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines
Genetic medicines, including CRISPR/Cas technologies, extend tremendous promise for addressing unmet medical need in inherited retinal disorders and other indications; however, there remain challenges...