PLoS ONE
Articles in this Issue
Understanding the effect of stay-at-home orders on psychological distress during the COVID-19 pandemic: Evidence from a longitudinal study in Australia
The extraordinary public policy response to COVID-19 in Australia saw extended lockdowns in some Australian states and territories, some of the longest in the world. This paper seeks to understand the...
Light-driven phenotypic plasticity in the depth-generalist coral, Pavona varians
Climate change is causing shifts in the spatial distribution of species and a reshuffling of the composition of multiple community types. On coral reefs, deep water can act as both refuges and refugia...
Computer-assisted rehabilitation system in the use of motor function recovery: A protocol for scoping review
Backgrounds Motor dysfunction, a prevalent sequela of neurological disorders such as stroke, Parkinson’s disease, and cerebral palsy, profoundly compromises patients’ capacity to perform daily activit...
Liver-related outcomes in patients with cirrhosis: The value of clinical and laboratory data and noninvasive tests
Background and Purpose Cirrhosis patients face high mortality risks from complications, emphasizing the need for prognostic tools to estimate risk of adverse liver outcomes based on cirrhosis etiology...
The management of patients who self-harm in adult inpatient mental health settings: A policy analysis of English NHS mental health trusts
The management of self-harm is a critical focus for staff in inpatient mental health settings. This study aimed to better understand how staff are guided through policies to manage self-harm via the f...
Research on urban resilience assessment and driving forces based on Production-Living-Ecological Spaces: A case study of the Three Gorges Reservoir Area in China
This study aims to develop a resilience evaluation approach based on production-living-ecological spaces and identify the key drivers of urban resilience in less-developed areas, taking the Three Gorg...
BHGNN-RT: Capturing bidirectionality and network heterogeneity in graphs
Graph neural networks (GNNs) have shown great promise for representation learning on complex graph-structured data, but existing models often fall short when applied to directed heterogeneous graphs....
Structural impact of synonymous mutations in six SARS-CoV-2 Variants of Concern
SARS-CoV-2 continues to spread and infect people worldwide. While most effort into characterizing variants of this virus have focused on non-synonymous changes, accumulation of synonymous mutations in...
The familiarity effect of Chinese stroke stimulus and imagery on contextual integration: Evidence from ERP correlates
The neural process of contextual integration has been examined through the phenomenology of semantic incongruence of words. The present study investigated whether the effort of contextual integration...
How does the institutional environment improve the entrepreneurial quality of returnees? A configuration analysis based on a complex system view
Enhancing high-quality entrepreneurship among returnees stands as a pivotal mechanism in driving the robust economic development of emerging economies. The inquiry into crafting an enabling institutio...
Vulnerability in research ethics: A systematic review of policy guidelines and documents
Background The history of research involving human subjects has demonstrated the importance of offering everyone an equal opportunity to participate in research, while safeguarding those who require s...
Isolation, identification, and evaluation of the antioxidant properties of lactic acid bacteria strains isolated from meat environment
Oxidative stress is a condition in which the body loses balance between the production of free radicals and the body’s ability to neutralize them. The role of antioxidants is to protect cells and tiss...
Rising burden of pancreatic cancer in China: Trends, drivers, and future projections
Pancreatic cancer is one of the most lethal malignancies globally, with increasing incidence and mortality trends. In China, the disease burden has escalated over the past three decades, yet comprehen...
How does social support influence autonomous physical learning in adolescents? Evidence from a chain mediation and latent profile analysis
Purpose This study examines how social support influences adolescents’ autonomous physical learning behavior, exploring the mediating roles of self-efficacy and exercise motivation, and the moderating...
The impact of family farming on Afrotropical flower fly communities (Diptera, Syrphidae): A case study in Tanzania
To provide empirical evidence about the impact of family farming on Afrotropical flower fly communities (Diptera, Syrphidae), we established a large experimental setup in the Morogoro area (Eastern Ce...
Design and evaluation of a mechanical pencil-based actuator for a wasp-inspired needle
In percutaneous interventions, long and thin needles are used to reach deep target locations within the body. However, inserting a long and thin needle into the tissue can cause needle buckling, resul...
Chiliadenus iphionoides: From chemical profiling to anticancer, antioxidant, α-amylase, and α-glycosidase activities
Recently, essential oils (EOs) have garnered attention for their biological properties as a source of natural compounds with anticancer, antibacterial, and antioxidant effects. Chiliadenus iphionoides...
Whole genome-based reclassification of several species of the genus Nonomuraea
Earlier classification methods lacked the resolution necessary to delineate species comparing to current standards, particularly since a significant number of bacterial taxa were described before the...
Exploring the relationship between self-care agency and quality of life in adults with diabetes: A cross-sectional study
Self-care agency is the ability to perform self-care. Clarifying the factors of self-care agency that are related to quality of life can help determine the most effective nursing support. This cross-s...
Masked face matching benefits from isolated facial features
Verifying the identity of an unfamiliar person is a difficult task, especially when targets wear masks that cover most of their faces. This presents a major challenge for law enforcement in border con...
Next-Generation Sequencing (NGS) in non-small cell lung carcinoma: A real-world experience in the public health system of Galicia (Northwest Spain)
The validation of several predictive biomarkers has improved the clinical outcomes of non-small cell lung carcinoma (NSCLC) patients. Single tests do not cover the mutational co-occurrences, so they d...
Novel extensions of k-harmonically convex functions and their applications in information science
Convex analysis theory has found extensive applications in optimization, information science, and economics, leading to numerous generalizations of convex functions. However, a drawback in the vast li...
Contrast-enhanced ultrasound with VEGFR2-targeted microbubbles for monitoring combined anti-PD-L1/anti-CTLA-4 immunotherapy effects in a murine melanoma model with immunohistochemical validation
Background Immune checkpoint inhibitors (ICIs) have emerged as a highly effective treatment option for patients with metastatic melanoma. As not all patients respond to ICI immunotherapy, imaging biom...
The association between care modality and hospitalizations and emergency department visits for ambulatory care-sensitive conditions during and after the pandemic in Ontario, Canada
The COVID-19 pandemic required a rapid transition to virtual care as a key strategy to maintain healthcare access while minimizing virus transmission risks. However, the impact of this shift on hospit...
Microsporidia infection alters C. elegans lipid levels
Microsporidia are fungal-related obligate intracellular parasites that infect many types of animals. Microsporidia have exceptionally reduced genomes resulting in limited metabolic capabilities and ar...