PLoS ONE
Articles in this Issue
Galectin-3 inhibition ameliorates hepatic steatosis in a multilineage 3D spheroid model
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease, and liver-related morbidity and mortality worldwide. MASLD is a multifactoria...
Correction: Geographical epidemiology of Hyalomma anatolicum and Rhipicephalus microplus in Pakistan: A systematic review
Semaglutide ameliorates diabetes-associated cognitive dysfunction in mouse model of type 2 diabetes
Background Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction, which significantly impacts the quality of life. Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, h...
Loss of a major venom toxin gene in a Western Diamondback rattlesnake population
The biochemical complexity and evolutionary diversity of snake venom composition reflects adaptation to the diversity of prey in their diets. However, the genetic mechanisms underlying the evolutionar...
Clinical characteristic and outcomes of pregnant women with COVID‐19: The PROUDEST prospective cohort study
The present study intended to characterize the clinical features and outcomes of SARS-CoV-2 infection at distinct pregnancy trimesters. A total of 260 pregnant women with SARS-CoV-2 infection at any p...
Description of the embryonic development of Holothuria floridana (Pourtalès, 1851) to produce juveniles for aquaculture and restocking
Overexploitation has severely affected the populations of Holothuria floridana, the second most valuable species of sea cucumber in the Gulf of Mexico and Greater Caribbean. Knowledge about its reprod...
Prevalence of diarrheal diseases and associated factors among under five children in Africa: A meta-analysis
Background Diarrheal diseases remain a major health threat for children under five in Africa, causing high rates of morbidity and mortality. The regional and continental pooled prevalence and risk fac...
Lack of knowledge of stakeholders in the pork value chain: Considerations for transmission and control of Taenia solium and Toxoplasma gondii in Burundi
Taenia solium and Toxoplasma gondii are important foodborne zoonotic parasites that cause substantial health and economic impacts worldwide. In Burundi, there was a lack of data on the knowledge, atti...
Attentional responses in toddlers: A protocol for assessing the impact of a robotic animated animal and a real dog
Background: Attentional processes in toddlers are characterized by a state of alertness in which they focus their waking state for short periods. It is essential to develop assessment and attention st...
Optimized Model Predictive Control for improving dynamic stability and steering accuracy in multi-axle cranes
The multi-axle crane, a long vehicle with high inertia, has historically struggled with steering efficiency and path-tracking performance. Various control strategies, including Proportional-Integral-D...
Development and validation of a nomogram for predicting false negative IGRA results in pulmonary tuberculosis patients using propensity score matching
Objective This study aims to explore factors influencing false-negative results in Interferon-Gamma Release Assay (IGRA) for patients with Pulmonary Tuberculosis (PTB), and develop...
Environmental mastery mediates relationships between mindsets and well-being
Research on mindsets, the extent to which people believe that people can change (incrementalism) has found that incrementalism is positively related to success in various domains. One explanation for...
Regulation of foliar salicylic acid at the heading stage enhances the grain 2-acetyl-1-pyrroline content and yield in fragrant rice
Despite numerous studies on salicylic acid (SA) and its functions, research regarding the regulation of foliar-applied SA at the heading stage in fragrant rice remains scarce. In this study, a pot exp...
Vertical transmission of Dengue virus type-3 and metagenomic virome profiles of Aedes aegypti mosquitoes collected in Kisumu, Kenya
Aedes aegypti is the main vector of several arboviruses including chikungunya, dengue, yellow fever and Zika. Beyond arboviruses, Aedes aegypti harbours insect-specific viruses (ISVs), which can modul...
Pathophysiological mechanisms of Postural Orthostatic Tachycardia Syndrome analyzed by means of hemodynamics
Postural Orthostatic Tachycardia Syndrome is characterized by an excessive increase in heart rate during postural changes without significant blood pressure alterations, often accompanied by symptoms...
Identification of fresh leaves of Anji White Tea: S-YOLOv10-ASI algorithm fusing asymptotic feature pyra-mid network
This study proposes the S-YOLOv10-ASI algorithm to improve the accuracy of tea identification and harvesting by robots, integrating a slice-assisted super-reasoning technique. The algorithm improves t...
Oral microbiota interactions with titanium implants: A pilot in-vivo and in-vitro study on the impact of peri-implantitis
Introduction Dental implant therapy is a reliable approach for restoring missing teeth, offering functional and aesthetic benefits in suitable clinical cases. However, there is sti...
Newly acquired word-action associations trigger auditory cortex activation during movement preparation: Implications for Hebbian plasticity in action word learning
Action word learning is believed to rely on mechanisms of Hebbian learning. However, this biological mechanism requires activation of the neural assemblies representing a word form and a corresponding...
Laparoscopic repair of the caesarean section scar niche: A prospective cohort study
Objective To evaluate the effect of laparoscopic repair of the large niche on short-term and long-term outcomes, i.e., extent of scar healing (increase in scar thickness or residual myometrium (RM) an...
Exploring the mechanism of Synechococcus sp. XM-24 in gastric cancer treatment via network pharmacology and molecular docking
Objective We investigated the potential molecular mechanisms of Synechococcus sp. XM-24 affect gastric cancer (GC) development. Furthermore, this study aimed to provide a theoretical basis for develop...
The association between salivary amylase gene copy number and enzyme activity with type 2 diabetes status
The association between salivary amylase gene ( AMY1 ) copy number (CN) and metabolic health parameters, such as insulin resistance, has been studied but with c...
Carbapenem-resistant Enterobacterales among patients with bloodstream infections in South Africa: Consolidated surveillance data, 2015–2021
Background A fifth of blood cultures from patients with infections acquired in a healthcare setting in South Africa will yield an organism. Carbapenem-resistant Enterobacterales (CREs), specifically K...
Few-shot network intrusion detection method based on multi-domain fusion and cross-attention
Deep learning methods have achieved remarkable progress in network intrusion detection. However, their performance often deteriorates significantly in real-world scenarios characterized by limited att...
Stochastic parametric skeletal dosimetry model for humans: Anatomical-morphological basis and parameter evaluation
Radiation exposure of the hematopoietic system that results in a radiation dose to bone marrow of more than 100 mGy leads to an increase in the risk of leukemia in humans. Excess relative risk of leuk...
A novel method for approximate solution of two point non local fractional order coupled boundary value problems
The aim of this paper is to investigate the solution of fractional-order partial differential equations and their coupled systems. A novel method is proposed, which effectively handles these problems...