PLoS ONE
Articles in this Issue
Factors influencing intentions to use Apple Pay: A behavioral perspective
The study aims to investigate factors influencing Apple Pay adoption, focusing on lifestyle congruence, perceived security, perceived trust, perceived financial control, ease of use, and relative adva...
Rehabilitation needs of adults after a brain tumour diagnosis: A scoping review
Rehabilitation can improve physical and cognitive function and quality of life in people who have been diagnosed with brain tumours. The aim of this scoping review was to examine the international evi...
Prevalence of malaria, anemia and associated factors among school children in Hawassa city, Sidama, Ethiopia
Background The recurrent occurrence of malaria and anemia are leading causes of morbidity and mortality in children especially in sub-Saharan Africa. In tropical regions, malaria is a major contributo...
Conversion of a telomere resolvase into a Cre-like site-specific recombinase
Hairpin telomere resolvases are a unique family of enzymes involved in producing the hairpin (hp) telomeres of bacterial organisms and phages that possess linear DNA’s terminated by hp telomeres. The...
Language in vivo vs. in silico: Size matters but Larger Language Models still do not comprehend language on a par with humans due to impenetrable semantic reference
Understanding the limits of language is a prerequisite for Large Language Models (LLMs) to act as theories of natural language. LLM performance in some language tasks presents both quantitative and qu...
Prevalence and associated factors of anemia during pregnancy at a tertiary hospital in Zambia
Background Anemia during pregnancy is among the leading causes of poor outcomes among mothers and neonates in low-resource settings like Zambia. This study aimed to determine the prevalence and factor...
Application of telemedicine in fatigue management for patients with multiple sclerosis: A scoping review
Background Fatigue is a prevalent symptom in people with Multiple Sclerosis, but evidence for the effectiveness of telemedicine in treating this symptom remains incomplete. Despite favorable clinical...
Use of hybrid quantum-classical algorithms for enhancing biomarker classification
Quantum machine learning (QML) combines quantum computing with machine learning, offering potential for solving intricate problems. Our research delves into QML’s application in identifying gene expre...
A new method for a priori practical identifiability
Background and objective : Practical identifiability analysis, i.e., ascertaining whether a model property can be determined from given data, is central to model-based data analysi...
Spatial distribution of pathogenic fungal isolates from clinical samples in Uganda: Diagnostic gaps and trends, January 2020 - May 2024
Background Pathogenic fungi cause approximately 13 million infections and 1.5 million deaths worldwide each year, yet surveillance and diagnosis remain inadequate in resource-limited settings. In Ugan...
Complex traces: Examining morbidity and mortality among 19th Century migrants to South Australia using a Complex Adaptive Systems framework
In multidisciplinary research interpreting interactions between diverse data sources requires a Complexity approach. A Complex Adaptive Systems (CAS) framework allows the relationships of multiple fac...
Canopy insect communities are shaped by the genes and phenotypes of their aspen hosts
1. Community genetics research aims to identify genetic and phenotypic mechanisms that shape communities as extended phenotypes. To date, most progress has been made identifying variation in herbivore...
Meteorological drought under historical and future climate scenarios in North Gojjam sub-basin, Abay River basin of Ethiopia
The impacts of climate change are expected to vary considerably across regional and local scales, underscoring the urgent need for localized assessments. This study investigates the spatio-temporal ch...
Sex-dependent effects of a gestational ketogenic diet on offspring birth and lifespan
Low-carbohydrate, high-fat ketogenic diets (KDs) are used for treating drug-resistant epilepsy, and other potential benefits, such as treating neurological disorders, metabolic syndrome, and cancer ar...
Fabrication and appraisal of targeted axitinib loaded bilosomes for the enhanced breast and ovarian anticancer activity
The goal of this study was the formulation and optimization by statistical means of bilosomal formulations of axitinib (AXT) in order to improve its anticancer efficacy in a targeted manner. A central...
Maximizing cost savings and clinical outcomes: A retrospective analysis of antimicrobial stewardship for meropenem utilization in Saudi Arabia
Background Meropenem, a key antibiotic for multidrug-resistant infections, is often misused, leading to antimicrobial resistance, increased healthcare costs, and excessive consumption. Optimizing its...
Frequency domain manipulation of multiple copy-move forgery in digital image forensics
Copy move forgery is a type of image forgery in which a portion of the original image is copied and pasted in a new location on the same image. The consistent illumination and noise pattern make this...
Characterizing the influence of racism-related stress and pandemic-related changes in social connections on cardiovascular health: Study protocol and theoretical framework
Background Cardiovascular-related morbidity and mortality among young adults are rising, and disparities between young Black and White women are immense. Health behaviors including physical activity a...
Extensive novel diversity and phenotypic associations in the dromedary camel microbiome are revealed through deep metagenomics and machine learning
The dromedary camel, also known as one-humped camel or Arabian camel, is iconic and economically important to Arabian society. Its contemporary importance in commerce and transportation, along with th...
Intensive luteal phase support in hormone replacement and modified natural cycle frozen embryo transfers in ovulatory patients: A propensity score-matched study
Background The optimal endometrial preparation protocol for frozen embryo transfer (FET) remains controversial, with different cycle regimens and luteal phase support strategies across studies yieldin...
Elucidating insights on how care was prioritized, adapted, and missed during and post pandemic
Globally, healthcare systems continue to recover and manage system demands, including our sustained HHR pressures exacerbated by the COVID-19 pandemic. Health system leaders need to understand how hea...
Cellular repressor of E1A-stimulated genes 1 enhances skeletal muscle performance through the stimulation of muscle differentiation and Akt-mTOR signaling pathway activation
Cellular repressor of E1A-stimulated genes 1 (CREG1), a glycoprotein secreted by various cell types, plays a crucial role in cellular differentiation and energy metabolism. While previous research has...
Efficacy of pharmacological and non-pharmacological therapy on chronic cancer pain intensity of adults with cancer: A network meta-analysis protocol
Background Chronic cancer pain is very common symptom in cancer patients, but this issue has not been satisfactorily resolved by the conventional three-step analgesic therapy. There are multiple non-p...
Long-term trends and future projections of the burden of tuberculosis among children and adolescents in China
Background China ranks third in estimated TB incidence in 2023, accounting for 6.8% of the global cases. TB in children and adolescents is a public health issue that today warrants priority attention...
Effects of quarantine and vaccination on the transmission of Lumpy skin disease: A fractional approach
Lumpy skin disease (LSD) is a viral infection that affects cattle, resulting from the lumpy skin disease virus. This study investigates the impact of vaccination and quarantine strategies on LSD outbr...