PLoS ONE
Articles in this Issue
Off-target sequence variations driven by the intrinsic properties of the Cas–sgRNA–DNA complex in genome editing
Genome-editing technologies hold significant potential across various biotechnological fields, yet concerns about possible risks, including off-target mutations, remain. To ensure safe and effective a...
Pesticide safety training to promote sustainable practices among French tree fruit and fresh vegetable farmers: A pre-post intervention survey
Objective Reducing pesticide exposure in agricultural activities remains a major challenge, particularly for crops that rely heavily on pesticides, such as fruits and vegetables. Integrated pest manag...
Preterm infants’ first breastfeeding attempt: Early initiation and performance: A large multicentre questionnaire study based on maternal observations
The Baby-friendly Hospital Initiative for neonatal wards and the World Health Organization recommend that stable preterm infants initiate breastfeeding regardless of gestational age, postmenstrual age...
Effect of the TIM-3/Gal-9 signaling pathway on macrophage polarization in peri-implantitis
Introduction Peri-implantitis (PI) is a common complication of oral implant surgeries. Understanding the role of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) and its ligand gale...
Predictors of weight progression among HIV infected adults on anti-retroviral treatment in Mekelle hospital, Tigray, Ethiopia: A longitudinal study
Background Human immunodeficiency virus (HIV) remains a significant global public health issue, causing over 35 million deaths until 2017. In 2013, 24.7 million people in sub-Saharan Africa were livin...
The novel mechanism of financing effect on companies development empirical study
As China’s economy continues to expand rapidly, the demand for capital among enterprises has surged, leading to an increased preference for short-term loans intended for long-term investments. An anal...
Factors associated with Anganwadi Workers’ service delivery of Integrated Child Development Services (ICDS) in rural India: A cross-sectional analysis of household and community health worker surveys
Objectives India’s 1.4 million Anganwadi Workers (AWW), a type of community health worker (CHW), serve 158 million beneficiaries under the Integrated Child Development Services (ICDS) program. They pl...
A culturally adapted psychologically informed, audiologist-delivered, manualized intervention for chronic tinnitus patients in Malaysia: Protocol for a randomized controlled feasibility trial
Background Tinnitus, a phantom auditory perception, varies from mild awareness to intolerable sounds that can severely impact psychological well-being, sometimes leading to suicidal ideation. While it...
Effect of glycemic control and type of diabetes treatment on TB treatment outcomes among people with TB-diabetes: A systematic review (updated August 2024)
Background Stringent glycemic control and/or using insulin either as a replacement for or in addition to oral hypoglycemic agents (OHAs) has been recommended for people with tuberculosis and diabetes...
Characteristics and actions in high-risk COPD in unstable patients: The EPOCONSUL audit
Objective: To assess the clinical characteristics of high-risk COPD patients considered not stable for having had moderate or severe exacerbations of COPD in the three months prior to the audited revi...
The efficacy of promoting sustained shared thinking through the use of activity books on parental empowerment; A quasi-experimental study
Background Parental empowerment serves as an essential driving force in promoting child development during the early childhood period. Sustained shared thinking is a method involving two or more indiv...
Evaluating interprofessional primary care teams in high-income countries: A scoping review protocol on the conceptualization and measurement of team functioning, effectiveness, performance and collaboration in primary care
Introduction The delivery of primary care (PC) services by interprofessional teams serves as the cornerstone for building high-performing PC systems. Interprofessional team-based care is a collaborati...
How did the urban and rural resident basic medical insurance integration affect medical costs?—Evidence from China
The Urban and Rural Residents’ Basic Medical Insurance (URRBMI) aims to improve access to medical services, increase medical insurance benefits to reduce medical costs, and ultimately achieve medical...
Prognosis, treatment decision-making and value: A qualitative exploration of the emerging role of breast cancer prognostic assays
Background Breast cancer prognostic assays are emerging as tools used by physicians in the cancer treatment decision-making process. This technology is new, and we must interrogate the integration of...
The dichotomy of human decision-making: An experimental assessment of stone tool efficiency
The physical properties of distinct raw materials, such as hardness, homogeneity, and grain size, have been recurrently suggested as some of the key reasons for human decision-making, namely the selec...
Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal hippocampus
Acute moderate-intensity exercise (AME) after learning has been reported to exogenously boost consolidation of hippocampus-dependent memory, resulting in improved long-term persistence. However, the n...
Determinants of acceptability of schistosomiasis mass drug administration among primary school children in Busega District, Northwestern Tanzania
Background Schistosomiasis is endemic in Tanzania, with a prevalence ranging between 12.7% to 87.6%. Mass drug administration (MDA) with praziquantel is the main recommended choice of preventive treat...
Type of pre-existing chronic conditions and their associations with Merkel cell carcinoma (MCC) treatment: Prediction and interpretation using machine learning methods
Objective This study examined the prevalence of pre-existing chronic conditions and their association with the receipt of specific cancer-directed treatments among older adults with incident primary M...
Comparison of kinesiotape, counterforce brace, and corticosteroid injection in patients with tennis elbow: A prospective, randomized, controlled study
Objective The aim of the study was to compare the effects of corticosteroid injection, kinesio tape, and counterforce brace on pain intensity, Common Extensor Tendon thickness, grip strength, and func...
Multiple timescales of context influence perceptual sensitivity to common pairings of musical pitch and timbre
Previous studies have established that musical pitch and timbre (specifically, spectral shape) perceptually covary: lower pitches are associated with darker timbres (less higher-frequency energy) and...
DNA sequence classification for diabetes mellitus using NuSVC and XGBoost: A comparative
Diabetes Mellitus is a global health concern, characterized by high blood sugar levels over a prolonged period, leading to severe complications if left unmanaged. The early identification of individua...
The role of albumin-corrected anion gap as a predictor of all-cause mortality in patients with Sepsis-AKI: A propensity score-matched cohort study
Background The potential association between albumin-corrected anion gap at admission and prognosis in patients with sepsis-induced AKI remains uncertain. The purpose of this study was to explore the...
Integrated bioinformatics and experimental validation identify ATF3 as a key gene in secondary brain damage after intracerebral hemorrhage
Background Secondary brain injury following intracerebral hemorrhage (ICH) is a critical clinical challenge, yet the molecular mechanisms driving neuronal damage remain poorly understood. This study i...
Mechanistic investigation of glycolysis and pyroptosis in colon adenocarcinoma tissues, and prognostic analysis of patient clinical outcomes
Background The exact mechanisms driving colorectal cancer (CRC) are yet to be fully elucidated. This study aims to confirm the reliability of a prognostic model for colon adenocarcinoma (COAD) by anal...
Gene variations and sweet taste sensitivity in Zambian adults with and without type 2 diabetes mellitus
Background Sweet taste perception and preference play crucial roles in dietary habits and health outcomes. Understanding the genetic basis of taste thresholds and preferences can provide insights into...