PLoS ONE
Articles in this Issue
HIV-1 controllers possess a unique CD8+ T cell activation phenotype and loss of control is associated with increased expression of exhaustion markers
Background HIV-1 controllers are a rare population of individuals that exhibit spontaneous control of HIV-1 infection without antiretroviral therapy. Underst...
Exosome-mediated modulation of radioresistance: The radiation-induced bystander effect in prostate cancer cells
Exosomes are involved in intracellular communication and mediate the radiation-induced bystander effect (RIBE). We assessed the ability of exosomes to modify the radiation response of PC3 and DU145 pr...
Low Th2 and high PD1+ TFh cells in blood predict remission after CTLA-4Ig treatment for 48 weeks in early rheumatoid arthritis
Objective To determine whether baseline CD4+ T helper (Th) cell subset proportions in blood may serve as predictive biomarkers for achieving remission 48 weeks after initiating CTLA-4Ig, anti-tumor ne...
ProSPective evaluation of the dIagnostic accuracy of siNe spiN non-contrast flatdEtectoR CT (FDCT) for the detection of intracranial hemorrhage in stroke patients - Protocol of a non-inferiority comparison to multi detector CT
Rationale Whether syngo DynaCT Sine Spin non-contrast flat detector CT (FDCT) imaging is sufficient to rule out intracranial hemorrhage in suspected acute stroke patients is unknown. Aim To determin...
Perception of healthcare administrators on the impediments of optimizing adverse events following immunization e-Reporting in Nigeria
Background Adverse events following immunization (AEFI) are any negative medical event that occurs after vaccination but may or may not be causally related to the vaccine. AEFI reporting is the gatewa...
VNC-Dist: A machine learning-based semi-automated pipeline for quantification of neuronal position in the C. elegans ventral nerve cord
The C. elegans ventral nerve cord (VNC) provides a genetically tractable model for investigating the developmental mechanisms involved in neuronal positioning a...
Predictors of suicide attempts among adolescents with suicidal ideations and a plan: Results from the National Survey on Drug use and Health (NSDUH)
Purpose Suicide remains an ongoing public health concern, especially among adolescents. While many studies investigated the transition from ideations to attempts, they did not specifically look at the...
Machine learning-based identification of diagnostic and prognostic mitotic cell cycle genes in hepatocellular carcinoma
Mitotic cell cycle (MCC) is a critical process in cell growth and division, and dysregulation of MCC genes may contribute to tumorigenesis. In this study, to identify diagnostic and prognostic value o...
Generative AI and academic scientists in US universities: Perception, experience, and adoption intentions
The integration of generative Artificial Intelligence (AI) into academia has sparked interest and debate among academic scientists. This paper explores the early adoption and perceptions of US academi...
Correction: The role of supplier-induced demand on the occurrence of information overload in managerial reporting environments
Fluid-derived lattices for unbiased modeling of bacterial colony growth
Bacterial colonies can form a wide variety of shapes and structures based on ambient and internal conditions. To help understand the mechanisms that determine the structure of and the diversity within...
Best practices of judicial governance: A scoping review protocol
Background Enhancing performance in the public sector is closely tied to institutional structures, governance models, and the behavior of public officials. In the Judiciary, these factors significantl...
Supportive care needs and quality of life among cancer patients in China: A cross-sectional study
Introduction In this study, the factors associated with unmet supportive care needs (SCNs) were examined, and their correlation with quality of life (QoL) among cancer patients was explored. Methods...
Single nucleus RNA sequencing of the cerebral cortex from genetically diverse inbred mouse strains reveals differences in pericyte and endothelial cell composition
Genetic background influences animal behavior and susceptibility to brain diseases. To evaluate how genetic background influences the relative number and/or types of cells in the brain, we performed s...
MiR-146a participates in regulating the progression of periodontitis through the Wnt/β-catenin signaling pathway
Objectives This study aims to investigate the potential role of miR-146a/Wnt/β-catenin signaling axis in the pathogenesis of periodontitis, using LPS-stimulated hPDLCs as a cell model. Methods Saliv...
Correction: Leadership development as a novel strategy to mitigate burnout among female physicians
Energy-efficient communication between IoMT devices and emergency vehicles for improved patient care
The rising integration of emergency healthcare services with the Internet of Medical Things (IoMT) creates a significant opportunity to improve real-time communication between patients and emergency v...
Unraveling the after-hours dilemma: Consequences of overworking among teleworkers—A scoping review protocol
Background Telework, also referred to as telecommuting, remote work, flexible work, and virtual work, involves working from a location different from the traditional office and often uses online commu...
Long-term neurological consequences following benzodiazepine exposure: A scoping review
Benzodiazepine acute withdrawal syndrome is well known, but the long-term neurological consequences of benzodiazepine exposure are much less familiar. A scoping review was conducted of electronic data...
Determinant factors of Chief Data Officer adoption in government: A topic model and structural equation modelling approach
With the generation of massive amounts of data, the Chief Data Officer (CDO) has been introduced in governments worldwide. Existing research on CDO is quite limited and primarily focuses on general de...
Eradication of Mycoplasma pneumoniae biofilm towers by treatment with hydrogen peroxide or antibiotic combinations acting synergistically
Mycoplasma pneumoniae is an important chronic, asthma-associated pathogen that is increasingly antibiotic-resistant. These bacteria have highly reduced genomes and lack a cell wall and numerous other...
Integrated DNA methylome and transcriptome analysis reveals the epigenetic regulatory mechanisms underlying maize response to copper stress
DNA methylation plays a crucial role in plants’ adaptation to environmental stresses. However, the precise role of DNA methylation in regulating the response of maize (Zea mays L.) to copper stress re...
A new design of wind power prediction method based on multi-interaction optimization informer model
The accurate prediction of wind power is imperative for maintaining grid stability. In order to address the limitations of traditional neural network algorithms, the Informer model is employed for win...
Study on deformation law of coal pore mechanism characteristics under peak cluster landform
In order to reveal the change rule of coal pore structure under the peak cluster landform, coal samples were taken from nine different mountain heights based on the vertical variability of the landfor...
Novel cervical pedicle screw design to enhance the safety insertion without compromising biomechanical strength
Background Lateral mass screw (LMS) is a more widely adopted method for posterior cervical spine fixation than the cervical pedicle screw (CPS). Despite its lower pullout strength, the insertions of L...