PLoS ONE
Articles in this Issue
Mathematical modelling of tissue growth control by positive and negative feedbacks
This study investigates the regulation of tissue growth through mathematical modeling of systemic and local feedback mechanisms. Employing reaction-diffusion equations, the models explore the dynamics...
Long term trends in NHS inpatient bed provision in England, 1960–2020
Objectives To examine the reduction in NHS inpatient hospital beds in England from 1960 until 2020, including five categories: Acute, Geriatric, Maternity, Mental Illness and Learning Disability beds;...
Unearthing prehistoric diets: First evidence of horse meat consumption in Early Bronze Age Sicily
This paper presents the earliest documented evidence for the presence and consumption of horse meat in Early Bronze Age Sicily, significantly revising previous understandings of equid use on the islan...
Optimizing gene prioritization for clinical diagnosis of metabolic genetic disorders
The expansion of next-generation sequencing has generated vast genomic datasets, but translating this information into clinically actionable tools for inherited metabolic disorders (IMDs) remains chal...
Assessing the genetic diversity of Ethiopian indigenous goat ecotypes at the hemoglobin locus and its associations with morphometric traits
Genetic variation is the baseline for viability, fitness, survivability, and improvement of livestock raised under diverse agroclimatic conditions. The study aimed to assess the genetic variation in t...
Spatial distribution and cluster analysis of road traffic accidents in Nepal
Background Road traffic accidents (RTAs) continue to pose a significant menace to global public health in the form of a high incidence of mortality, disability and economic expense. Their space-time t...
Spatio-temporal evolution and convergence patterns of E-commerce development in China: Regional disparities and policy implications
The rapid development of e-commerce has become a key driver of economic transformation and regional development in China. However, significant spatial and temporal disparities persist across regions....
Identification of BOLD engine deficiencies and suggestions for improvement based on a curated Tachina (Diptera) record set
The increasing number of Barcode of Life Database (BOLD) records per species and genus leads to contradictory species assignments within Barcode Index Numbers (BINs), serving as identifiers for the BO...
Computational model of alpha 7 nicotinic acetylcholine receptor in thalamic reticular nucleus neurons and their involvement in network states
Human 15q13.3 microdeletion syndrome (15q13mds) is a genetic disorder caused by a heterozygous deletion of multiple genes, including the CHRNA7 gene, which encodes the α7 nicotinic acetylcholine recep...
Comparison of sequential data analysis and functional data analysis for locomotor adaptation
Learning rates for skills such as walking may depend on circumstances or time, while incentivization with punishments or rewards may affect human skill learning. We consider a state space model for dy...
Early multimodal vasopressor strategy in septic shock (TRICYCLE)—Study protocol for a randomized controlled clinical trial
Introduction The main mechanism of hypotension in septic shock is persistent vasodilation secondary to vascular hyporeactivity despite high endogenous catecholamine levels and despite endogenous activ...
Perceptions of barriers and facilitators to opioid reduction after total joint arthroplasty among orthopedic surgeons practicing in Canada, Japan, and the Netherlands: A qualitative description study
Opioid analgesics are commonly prescribed after total knee and hip arthroplasty to manage pain. Rates of opioid prescribing after arthroplasty differ by country, suggesting differences in policies or...
Facilitators and barriers to building research capacity among clinical nurses: A systematic review protocol
Background Clinical nurses’ research capacity is essential for building a research-active nursing workforce and advancing evidence-based practice. Despite increasing global attention, few systematic r...
Comparison of the clinical outcomes between conventional intracytoplasmic sperm injection (ICSI) and PIEZO-ICSI in women undergoing the first cycle of in-vitro fertilization
The effectiveness of PIEZO-ICSI (P-ICSI) compared to conventional ICSI (C-ICSI) is still controversial. The only confirmed effectiveness of P-ICSI compared to C-ICSI is that it can reduce the number o...
FDA-DETR: A frequency-aware DETR with dynamic query and adaptive multi-task optimization for oriented small object detection
Oriented small object detection remains a challenging problem in computer vision, largely due to the weak feature representation and high computational cost of existing detection Transformer (DETR)-ba...
Correction: The Temporary Incapacity (TI) register as a complementary system to traditional epidemiological surveillance during the COVID-19 pandemic in Spain
Optimization of flooding parameters and enhanced-efficiency development for surface-modified nano-SiO₂ emulsion in low-permeability sandstone reservoirs
Low-permeability reservoirs, characterized by poor reservoir quality and pronounced heterogeneity, consistently encounter engineering challenges during waterflooding operations, such as suboptimal dis...
A novel strategy for resource utilization of oily drilling waste fluids in northern Shaanxi: Stepwise flotation of bentonite and barite using SDS and interfacial reaction mechanisms
Northern Shaanxi’s oil-gas drilling produces large amounts of waste drilling fluids with high-value solids (barite, bentonite). Traditional disposal causes resource waste and pollution. This study pro...
“Double Bind” with a twist: A corpus-assisted discourse study of gender performances of male and female entrepreneurs on Twitter (now X)
Previous studies have demonstrated that women in male-dominated fields face a challenging “double bind”—they must display traditionally masculine traits while maintaining feminine qualities. This stud...
Protocol for a study to evaluate the safety and efficacy of prophylactic negative pressure wound therapy after abdominal perineal resection (VACPAC study)
Introduction Abdominal perineal resection (APR) is a surgical procedure for rectal cancer that frequently results in perineal wound surgical site infections (SSI), particularly in high-risk patients u...
One-on-one and group-based physical activity intervention compared to a waitlist control for post-secondary student mental health and social well-being: A 3-arm parallel randomized controlled trial protocol
Introduction Physical activity (PA) service provision in the post-secondary context is recognized as important for promoting student mental health. Nonetheless, most evidence is of poor quality and la...
Correction: Near point-of-care HIV viral load testing: Cascade after high viral load in suburban Yangon, Myanmar
MACML: Marrying attention and convolution-based meta-learning method for few-shot IoT intrusion detection
The widespread deployment of Internet of Things (IoT) devices has made them prime targets for cyberattacks. Existing intrusion detection systems (IDSs) heavily rely on large-scale labeled datasets, wh...
A multi-strategy enhanced secretary bird optimization algorithm for high-precision inverse kinematics in robotic arms
The assembly of pyrotechnic grain demands high precision and stability in robotic arm motion control due to the small shell apertures and stringent assembly accuracy requirements. Inverse kinematics i...
The speed of change in climate and land cover is associated with the speed of biodiversity changes in avian assemblages of the United States
Changes in climate and land use land cover are a widely recognized threat to the stability of natural species assemblages’ composition and biodiversity. Species-specific responses to these changes can...