PLoS ONE
Articles in this Issue
Exosomal miR-320b regulates cardiomyocyte FOXM1 expression and may serve as an early-stage compensatory mechanism in obstructive sleep apnea
This study aimed to investigate the potential compensatory role of plasma exosomal microRNAs (miRNAs), particularly miR-320b, in mitigating early myocardial damage in severe obstructive sleep apnea (O...
Ageing-driven molecular and functional changes in the bovine endometrium
Understanding how ageing impacts endometrial function is crucial for preserving fertility in older females. While ageing-related cellular dysfunction and inflammation are observed in the bovine uterus...
Phytochemical characterization, anticancer potential, and nanoemulsion-based delivery of Chiliadenus montanus
Chiliadenus montanus (Vahl) Boiss. (Asteraceae) is a pharmacologically significant plant with different potent pharmacological properties. This study aimed to evaluate the phytochemical and anticancer...
Diabetic retinopathy as the primary predictor of mild cognitive impairment in type 2 diabetes: Insights from machine learning models
Mild cognitive impairment (MCI) is a significant and increasingly recognized problem in individuals with type 2 diabetes mellitus (T2DM). This study aims to develop a machine-learning model to predict...
Edge percolation centrality: A new measure to quantify the influence of edges during percolation in networks
Numerous centrality measures exist to quantify the influence of edges within a network, with edge betweenness being one of the more well-known measures. However, such measures are inadequate in networ...
Construction of an automated machine learning-based predictive model for postoperative pulmonary complications risk in non-small cell lung cancer patients undergoing thoracoscopic surgery
Objective To develop a predictive framework integrating machine learning and clinical parameters for postoperative pulmonary complications (PPCs) in non-small cell lung cancer (NSCLC) patients undergo...
Gene electrotransfer with flow-through microchannel and lower alternating voltage generated induced pluripotent cells from human lymphoblastoid cell lines
Induced pluripotent stem cells (iPSCs) are useful for studying genetic and rare diseases and can be generated by reprogramming immortalized lymphoblastoid cell lines (LCLs) stored in global repositori...
Postural control and trunk muscle activation in transtibial amputees: A pilot electromyographic study
Transtibial amputation affects postural stability, requiring trunk muscle analysis to support balance and rehabilitation. This pilot study aimed to compare trunk muscle activations during postural swa...
Impacts of resistance training combined with vibration training on the IGF-1/PI3K/AKT/FOXO3 axis and clinical outcomes in patients with sarcopenia: A protocol for a randomized controlled trial
Background Sarcopenia is an age-associated disorder characterized by a progressive decline in skeletal muscle mass, strength, and physical function. The condition is linked to low levels of anabolic h...
How do digital platform capabilities affect service innovation in service manufacturing firms? The role of knowledge creation and environmental uncertainty
The recent wave of scientific and technological revolutions, coupled with industrial advancements, has catalyzed the rise of service-oriented manufacturing enterprises in China. Despite their notable...
Optimizing access to fruits and vegetables in rural communities: A decision-making model for the placement of produce markets
Many rural communities experience limited access to fruits and vegetables (FV) and may benefit from food environment interventions to increase the number of produce markets selling FV. Systems analysi...
The experience of mental effort during a continuous performance task: Exploring the influence of task- and person-based factors
Using mental effort to engage in cognitively demanding tasks is associated with a conscious experience, and this experience serves as a regulatory mechanism. However, important issues remain in our un...
Social skills development in children aged 4–8 years
The primary goal of this study was to examine children’s social skills (SS) development by comparing various factors (countries, genders, and age groups). Additionally, this study aimed to analyze how...
Supervised spike sorting feasibility of noisy single-electrode extracellular recordings: Systematic study of human C-nociceptors recorded via microneurography
Sorting spikes from noisy single-channel in-vivo extracellular recordings is challenging, particularly due to the lack of ground truth data. Microneurography, an electrophysiological technique for stu...
Unilateral biportal endoscopic lumbar interbody fusion versus minimally invasive transforaminal lumbar interbody fusion in the treatment of lumbar degenerative diseases: a retrospective multicenter cohort study
Background Minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) is one of the most commonly used methods for lumbar fusion. However, in recent years, the unilateral biportal endoscopic...
Multi-omics analysis of parthanatos related molecular subgroup and prognostic model development in stomach adenocarcinoma
Stomach adenocarcinoma (STAD), the most prevalent histological subtype of gastric cancer, exhibits high heterogeneity and poor prognosis, posing significant therapeutic challenges. Parthanatos, a dist...
Prevalence and associated factors of delay in seeking malaria treatment among under five children in the Horn of Africa: A systematic review and meta-analysis
Introduction Malaria is a global public health problem, particularly in sub-Saharan African countries. It is responsible for 90% of all deaths worldwide. To reduce the impact and complications associa...
Validation and potential refinement of the Malaysia Medication Adherence Assessment Tool (MyMAAT) among patients with non-dialysis chronic kidney disease
Background Medication adherence is essential for managing chronic kidney disease (CKD) and preventing its progression. In Malaysia, adherence is commonly assessed using the 12-item Likert scale Malays...
Water use efficiency of Cupressus gigantea is higher in mountain slope habitats compared to riverside habitats
Cupressus gigantea is an endemic species of the Yarlung Zangbo River in Tibet, China, and is designated as a national key protected wild plant species. It is uniquely distributed in the specific secti...
Determinants of sustainable solid waste management in Jimma City, Southwest Ethiopia
Background Exponential urban growth has led to a significant increase in solid waste production, making solid waste one of the most significant issues faced by urban spaces in developing countries. Th...
Dichotic turncoats: Lateralization of auditory processing in two dichotic listening tasks using melodies and syllables
When confronted with dichotically presented syllables, right-handed healthy individuals tend to consciously perceive syllables presented to the right ear more often. This phenomenon, known as the righ...
The development of the “Laab Nuer Model” for food safety management in handling traditional Lanna cuisine in Thailand
Food contaminants in traditional Lanna cuisine persist as a public health issue since there is no readily apparent method to prevent this contamination. Hence, this study was conducted to develop a pr...
Time of urine sampling may influence the association between urine specific gravity and body composition
Urine specific gravity (USG) is frequently utilized in sports practice and research to assess hydration status. Prior research suggests that individuals with large amounts of fat-free mass (FFM) and m...
Enhanced Bézier curve-based trajectory planning for high-altitude autonomous trucks
Highway freight transport is the backbone of Tibet’s logistics network, accounting for 76.4% of regional freight movement (Tibet Bureau of Statistics, 2024). Challenging alpine road conditions—charact...
Tunable single- and dual-wavelength lasers around 1.4 μm in Nd:LuGdAG crystal
We present the first diode-pumped tunable single- and dual-wavelength (DW) laser operation near 1.4 μm spectral region in Nd:LuGdAG (Nd:LGAG) crystal on the 4F3/2 → 4I13/2 transition. Three distinct l...