PLoS ONE
Articles in this Issue
Framework for analyzing MAE-derived immunopeptidomes from cell lines with shared HLA haplotypes
Background The goal in vaccinology is to identify candidate antigens for clinical trials that will elicit an immune response for a significant portion of the target population. Unfortunately, promisin...
Blood flow-restricted resistance training modulates miRNAs to improve early hypertensive cardiac function
Objective The aim of this study was to explore the differentially expressed miRNAs in the hearts of rats protected from early spontaneous hypertension by blood flow-restricted resistance training and...
Collaborative representation based on enhanced tensor robust PCA for hyperspectral anomaly detection
This paper presents a novel hyperspectral anomaly detection (HAD) method, ETRPCA-CRD, which integrates enhanced tensor robust principal component analysis (ETRPCA) with collaborative representation de...
Altered carnitine-acylcarnitine profiles in levothyroxine-treated congenital hypothyroid patients with fatigue: An LC-MS/MS-based study from Bangladesh
Congenital hypothyroidism (CH), characterized by insufficient thyroid hormone production at birth, is frequently associated with fatigue, particularly in cases with delayed diagnosis. This study emplo...
Comparing Guillain-Barré syndrome outcomes between rural and urban hospitals in the United States: A retrospective cohort study
Background and purpose Rural-urban disparities in neurological care have been well documented, but limited data exist regarding Guillain-Barré Syndrome (GBS). This study examines differences in patien...
The decline of local wisdom in managing the Wain River protected forest near Indonesia’s new capital city buffer zone
The Wain River protected forest serves not only as a watershed but also holds a critical role in sustaining hydrological functions. The Sultan of Kutai Kertanegara Sultanate initiated ecological engin...
Evaluating the diagnostic performance of OpenBioLLM in neurology: A case-based assessment of a medical large language model
In the evolving field of neurological healthcare, deep learning technologies are gaining recognition for their potential to enhance diagnostic accuracy. Transformer-based models, particularly large la...
The efficacy and safety of electrical acupoint stimulation (EAS) for knee osteoarthritis (KOA): A GRADE-assessed systematic review, meta-analysis and trial sequential analysis
Electrical acupoint stimulation (EAS) is proposed as a potentially beneficial treatment for patients suffering from knee osteoarthritis (KOA). This systematic review and meta-analysis aims to assess t...
Insulator defect detection in severe weather using improved YOLOv8
Insulators, as a vital component of the power system, encounter issues such as misdetection, leakage, and low detection accuracy in inclement weather. To address this problem, this paper proposes a YO...
Effect of egg irradiation on development and sterility of wild-type and Wolbachia trans-infected Aedes aegypti mosquito vectors
Sterile Insect Technique (SIT), Incompatible Insect Technique (IIT) or a combination of the two has become alternative promising vector control approaches. In order to apply these approaches, the targ...
Minimising the impact of infectious outbreaks on resident quality of life: A qualitative proof of concept study using the Adult Social Care Outcomes Toolkit (ASCOT)
Introduction Infection control measures (ICMs) used to mitigate the effects of infectious outbreaks in care homes impact on resident quality of life (QoL). This qualitative proof-of-concept study expl...
Prevention of functional and cognitive impairment through a multicomponent exercise program during and after hospitalization of older adults (PREDISC): Study protocol for a multicenter randomized clinical trial
Hospitalisation in older adults is frequently associated with a significant risk of functional and cognitive decline. This study aims to evaluate the effectiveness of a multicomponent exercise program...
Study to determine the impact of seatbelt on Maxillofacial bone fractures and associated injuries in road traffic accidents in Saudi Arabia: A 10 years retrospective study
Background Every year around the world road traffic accidents (RTAs) cause 1.19 to 1.35 million deaths and 20–50 million non-fatal injuries that result in long-term disabilities and loss of potential...
The effect of temperature and nitrogen source modulation on Pseudomonas fluorescens AQP671 ice recrystallization inhibition activity
Cold-adapted organisms have developed many different mechanisms to protect themselves from freezing temperatures. One of these mechanisms is ice recrystallization inhibition (IRI) activity. IRI refers...
Psychometric properties of the Persian version of the hospitalized older adults’ dignity scale for measuring dignity during acute hospitalization
Background Providing dignified care is an essential aspect of high-quality nursing, and upholding patients’ dignity is emphasized in the professional standards for nurses. This research evaluated the...
Investigation of phytochemical and biochemical attributes of hypoglycemic activity of Atriplex crassifolia (C.A. Mey) extracts in alloxan diabetic animal model
Diabetes mellitus is a widespread medical and public health issue that can lead to significant health impairment. The objective of the study was to assess the antidiabetic effectiveness of various ext...
Obstructive airway disorders affecting individuals with hereditary hemorrhagic telangiectasia: A database review
Rationale and objective Dyspnea is a common symptom with varied causes. Pulmonary vascular involvement in Hereditary Hemorrhagic Telangiectasia (HHT) includes pulmonary arteriovenous malformations (PA...
Structural assessment of family and educational influences on student health behaviours: Insights from a public health perspective
The 2024 World Health Organization report reveals that 81% of adolescents worldwide fail to meet the recommended level of physical activity, highlighting a serious global public health challenge. This...
A circulating microRNA panel enhances the diagnosis of cholangiocarcinoma
Background and aim Cholangiocarcinoma (CCA), a malignancy with a high incidence in regions endemic for the liver fluke Opisthorchis viverrini, is frequently characterized by alterations in the p53 tum...
Large-scale carbon and nitrogen isotopic investigations into caprine diet and management at Tepe Yahya, southeastern Iran
Tepe Yahya, a small urban center in southeastern Iran, was embedded in cross-cultural exchange with the many entities of southwestern Asia. Besides an understanding that caprines dominated the animal...
COVID-19 vaccinations among German university students: The role of fear of COVID-19 and risk assessment
Studies on the reasons why people have opted for COVID-19 vaccination have shown that a higher fear of COVID-19 and a higher risk assessment of developing a serious illness in case of a SARS-CoV-2 inf...
Re-emerging outbreaks of chikungunya virus infections of increased severity: A single-center, retrospective analysis of atypical manifestations in hospitalized children during the 2019 outbreak in Bangkok, Thailand
This retrospective observational study assesses the clinical characteristics, atypical manifestations, and treatment outcomes in pediatric patients hospitalized with chikungunya virus (CHIKV) infectio...
Comparison of cellular responses of cultured fibroblasts from Iriomote wild cats and domestic cats exposure to polyinosinic:polycytidylic acid
The Iriomote wild cat is endemic to Iriomote Island. The total population is only 100 cats. These cats are thus listed as critically endangered on the IUCN Red List. Infectious disease is a risk facto...
Deep time evolution of the Latitudinal Diversity Gradient: Insights from mechanistic models
The latitudinal diversity gradient (LDG) designates the increase in species richness toward the tropics. While geological and climatic changes are recognized as key drivers, the precise factors and th...
Thangka super-resolution diffusion model based on discrete cosine transform domain padding upsampling and high-frequency focused attention
Thangka is a traditional Tibetan painting art form, possessing profound cultural significance and a unique artistic style. Image super-resolution technology, as an effective means of digital preservat...