PLoS ONE
Articles in this Issue
Television watching and cognitive outcomes in adults and older adults: A systematic review and dose-response meta-analysis of observational studies
This systematic review and meta-analysis aimed to examine the association between television watching and cognitive outcomes in adults and older adults as the current evidence is inconsistent. We sear...
Advection, diffusion and linear transport in a single path-sampling Monte-Carlo algorithm: Getting insensitive to geometrical refinement
We address the question of numerically simulating the coupling of diffusion, advection and one-speed linear transport, with a specific focus on managing geometrical complexity. We base our work on rec...
Interest in public involvement, engagement and participation in research among patients with asthma: A secondary analysis of the EPI-ASTHMA study
Patient and Public Involvement, Engagement and Participation (PPIEP) is essential in asthma research due to the disease’s complexity. However, information regarding the characteristics of patients wit...
Botulinum toxin type A success rates and predictive factors for favourable outcomes in paediatric patients with acquired esotropia
Purpose This study aimed to assess the efficacy of botulinum toxin type A in treating childhood-acquired comitant esotropia and identify predictive factors of treatment success. Methods This retrosp...
Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment
Endometriosis is characterized by the presence of endometrial tissue outside the uterine cavity. The administration of drugs designated for this condition has significant adverse effects, such as sign...
Support To Rural India’s Public Education System (STRIPES2) and impact on numeracy and literacy scores: A cluster randomized trial in rural villages of Madhya Pradesh, India
Introduction Rates of primary school enrolment have improved in India, but levels of learning achievement remain low. In the Support To Rural India’s Public Education System (STRIPES) trial, a para-in...
The type III secretion system translocases IpaC, SipC, and BipC are partially folded alpha helical proteins lacking in tertiary structures
The Type III secretion system (T3SS) is essential in the virulence of many bacterial pathogens that cause infectious diseases in humans. The T3SS consists of an injectisome that bacteria use to inject...
Impingement of suspending droplets with coming ones at different off-central distances: A molecular dynamics study
Impingement of binary nanodroplets on solid surface can produce various outcomes, which are very important to various practical applications, such as lab on a chip and digital microfluidics. In the pr...
Brief mindfulness coaching enhances selective attention in medical scientists: A pilot study
Medical scientists have dual commitments to clinical care and research efforts. Such commitments can create hectic and stressful work schedules, which may impact on well-being and cognition. In this s...
Visual enumeration remains challenging for multimodal generative AI
Many animal species can approximately judge the number of objects in a visual scene at a single glance, and humans can further determine the exact cardinality of a set by deploying systematic counting...
Intra- and intergenerational costs of handicapping in the Saffron Finch (Sicalis flaveola), a thraupid with delayed plumage maturation
Life history theory posits negative trade-offs between current reproduction and survival and between current and future reproduction. We tested if the Saffron Finch (Sicalis flaveola), a sexually dich...
Low-carbon optimal scheduling of integrated energy systems based on multi-strategy ameliorated goose algorithm and green certificate-carbon trading coordination
The integrated energy systems (IES) in China face a dual challenge under the “dual-carbon” targets: maximizing renewable energy utilization while minimizing carbon emissions. Traditional tiered carbon...
Morphometric analysis for prioritizing critical areas of Urpash watershed in Sindh catchment of the lesser Himalayas using RS and GIS approach
Effective soil and water conservation is critical in fragile watersheds prone to erosion. However, assessing erosion susceptibility in ungauged watersheds remains challenging due to the lack of observ...
C3AR1 may aggravate diabetic nephropathy by mediating oxidative stress via ITGB2 regulation in renal tubular epithelial cells
Diabetes nephropathy (DN) is the most common chronic complication of diabetes and has become an important cause of end-stage renal failure. Oxidative stress and inflammatory response play important dr...
Enhanced RGB-D SLAM through orthogonal plane constraints and point-line-plane collaborative optimization
Accurate visual localization in complex indoor environments remains a significant challenge due to feature degradation and cumulative errors. In response, we propose PLPM-SLAM, a novel RGB-D SLAM fram...
Formalized aspect-oriented misuse case for specifying crosscutting security threats and mitigations
Software applications are essential for managing daily life activities, including social interactions and business transactions, that significantly increase the need for security in sharing sensitive...
Pension levels of chinese institutions during the transition period: A case study of universities
Background With China’s rapidly aging population, the combined effects of this demographic shift and a growing wave of retirements present significant challenges for the sustainability of the basic pe...
Process optimization of modified sodium persulfate for the remediation of total petroleum hydrocarbon contaminated soil
Petroleum hydrocarbon (TPH) contamination at industrial sites poses severe ecological and health risks to humans. However, conventional persulfate oxidation suffers from low efficiency and high oxidan...
Combinatorial effects of Zingiber officinale and Citrus limon juices: Hypolipidemic and antioxidant insights from in vivo, in vitro, and in silico investigations
The combined use of Zingiber officinale (ginger) and Citrus limon...
Relationship between Sn elemental background values and regional longevity levels—Data from Yunnan, China
The relationship between the geographic environment and human health has been a long-standing focus of scientific inquiry. Sn as an essential trace element for the human body, play vital roles in indi...
Effect of opaque porcelain on color and aesthetic outcomes of titanium-abutment implant restorations
Objective This study evaluated the effects of opaque porcelain (OP) on color parameters and aesthetic outcomes of all-ceramic implant restorations with varying abutment types and restoration thickness...
Resolution of physics and deep learning-based protein engineering filters: A case study with a lipase for industrial substrate hydrolysis
Computational enzyme design remains a powerful yet imperfect tool for optimizing biocatalysts, especially when targeting non-natural substrates. Using design tools we investigated Pseudomonas aerugino...
Everything, everywhere, all at once - Surveillance and molecular epidemiology reveal Melissococcus plutonius is endemic among Michigan, US beekeeping operations
European foulbrood (EFB) is a severe bacterial disease of honey bee brood often leading to significant declines in colony health and honey production. The dearth of data on this disease in the United...
Evaluation of statistical regression models in predicting factors influencing HBV and HIV among female sex workers in Ghana: A Bio-behavioural survey
Purpose This study aims to evaluate the effectiveness of parametric statistical methods—specifically logistic regression, Poisson regression, and Cox proportional hazards models—in identifying factors...
Transient vascular occlusions in a zebrafish model of mycobacterial brain infection
Mycobacterial brain infection, for example tuberculous meningitis (TBM), caused by Mycobacterium tuberculosis, is a severe manifestation of tuberculosis that occurs when the bacteria invade the brain....