PLoS ONE
Articles in this Issue
Heterogeneity among Venezuelan migrants in terms of coping in the context of the population exodus from Venezuela
This study concentrates on the unparalleled exodus of Venezuelans in recent years. By June 2024, the global population of Venezuelan migrants and refugees had reached 7.7 million, with 6.6 million set...
Genomic insights into Yanbian cattle: Breed-specific selective sweeps identified by whole-genome sequencing
The Chinese Yanbian Yellow cattle are an indigenous East Asian breed, closely related to the Korean Hanwoo cattle, and presumably share the same origin. However, unlike Hanwoo, which has undergone app...
Construction and validation of a prognostic model based on mitochondria-associated endoplasmic reticulum membranes gene signature in LUAD patients
Background Mitochondrial-associated endoplasmic reticulum membranes (MAM) are implicated in various malignancies, but their prognostic value in lung adenocarcinoma (LUAD) remains underexplored. Meth...
Single-cell transcriptomic analysis reveals the association of Ccl6+Ccr2+Arg1+ macrophages with renal interstitial fibrosis in AKI
Background Acute kidney injury (AKI) is a major health burden with a high risk of progression to chronic kidney disease (CKD). Renal fibrosis is the ultimate outcome of CKD progression, with M2 macrop...
Real-world trends in rheumatic disease rates among pregnancies in Ontario, Canada: A repeated cross-sectional study
Objective Despite increasing rheumatic disease prevalence among female individuals in Ontario, Canada, research is limited on whether this has translated to an increased proportion of pregnancies with...
Substrate degradation and black soldier fly larvae bioconversion performance profile on co-digested oil palm biomass-based feedstock
Utilization of oil palm empty fruit bunches (OPEFB) is limited due to its low nutrient value but high lignocellulose content. Black soldier fly larvae (BSFL, Hermetia illucens L.) is capable of conver...
Role of c-Myc activating the transcription of PD-L1 in immune escape during benzene-induced malignant transformation of human lymphoblasts
Benzene is a widely used industrial raw material. Benzene and its metabolite hydroquinone are believed to be related to the occurrence of benzene-related leukemia. Epidemiological studies have reveale...
Integration of wearable devices and artificial intelligence in Alzheimer’s disease: A scoping review protocol
The incidence of Alzheimer’s disease (AD) continues to rise, and predictive models combining artificial intelligence (AI) with wearable devices offer a new approach for its detection and diagnosis. Ex...
How do college coaches in the United States identify youth female and male soccer players?
Talent identification (TI) in soccer is a complex and multifactorial process within the context of collegiate sport in the United States, where coaches must assess performance-ready athletes often und...
Genome-wide identiffcation of the WRKY gene family in poplar and the positive role of PsnWRKY95 in response to cadmium stress
WRKY is a crucial transcription factor family in plants, participating in a variety of physiological processes and stress responses. In this study, we identified 102 WRKY genes from the poplar genome,...
Health-economic evaluation of statins versus lifestyle changes for cardiovascular disease prevention
Introduction The German Federal Ministry of Health aims to improve cardiovascular health by expanding statin eligibility. However, the shift in funding from lifestyle-based preventive programs to stat...
ETS2 targets ZMYND11 to inhibit thyroid cancer progression via the mTOR signaling pathway
Background Despite advancements in thyroid cancer (THCA) treatment, the prognosis for advanced cases remains poor. Cellular senescence is crucial in tumor progression, with ETS2 emerging as a key regu...
Sun protection behavior beliefs among adults living in rural United States: A qualitative study in Minnesota
Although skin cancers are considered mostly preventable, more people in the US are diagnosed with skin cancer than all other cancers combined. Sun safety recommendations include wearing sun-protective...
The impact of outdoor walking interventions on frailty among older adults with mobility limitations: Findings from the Getting Older Adults Outdoors (GO-OUT) study
Objective Diverse strategies are needed to reduce frailty. This study evaluated the effects of two behavioural interventions targeting outdoor walking on reducing the level of frai...
It’s not difficulty that matters, but strategy: Perceived stressor, functional and dysfunctional coping strategies in ultra-trails of extreme duration
To date, no studies have proposed specific taxonomies of stressors and coping strategies used to manage them by ultra trail runners in races longer than 200 miles, with existing research focusing on s...
Research on the influence of the morphology of coarse aggregates from Reclaimed Asphalt Pavement (RAP) on the mechanical properties of asphalt concrete based on finite element modeling
Using recycled coarse aggregates (RCA) to prepare asphalt mixtures can reduce the consumption of natural sand and gravel resources and solve the environmental pollution problem caused by waste asphalt...
Evaluation of collector spacing, positioning, and nozzle selection methods on water distribution uniformity in center pivots
Proper design and periodic evaluation of center pivot irrigation systems are essential for ensuring uniform water distribution and improving water use efficiency in irrigated agriculture. This study a...
Hormonal contraceptives and body composition by use of stable isotope dilution techniques among women of reproductive age in Nyeri County, Kenya
Background Hormonal contraceptives are widely used by women of reproductive age (WRA) globally, yet their impact on body composition remains poorly understood, particularly in low-resource settings. T...
Wound healing effects of 80% methanol and solvent fractions of the leaf of Cordia Africana Lam: (Boraginaceae) against wound models in mice
Background Chronic wounds present a major health challenge, and traditional remedies are frequently employed in developing nations for wound treatment. This study sought to assess the safety and effec...
The admissibility of digital evidence from open-source forensic tools: Development of a framework for legal acceptance
The proliferation of cybercriminal activities from 2023 to 2025 has highlighted the critical role of digital forensics in legal proceedings; however, resource constraints often limit access to effecti...
Self-guided versus facilitator-guided debriefing in immersive virtual reality simulation: Protocol for a randomized controlled non-inferiority trial assessing teamwork skills in medical students
Simulation-based medical education has been shown to be more effective but also logistically demanding and costly compared to other educational strategies in developing medical skills. Immersive virtu...
Validation of the FVB/N-Tg(HSA* LR)20bCath mice of myotonic dystrophy using swallowing function assessment, histology, and immunofluorescence analysis
Myotonic dystrophy is associated with dysphagia, which can lead to severe complications such as aspiration pneumonia and choking. However, few histopathological studies on dysphagia in myotonic dystro...
Repopulation of the gut microbiota after a screening colonoscopy
Objective Role of microbiome has been highly studied for its association with various medical conditions. After a colonoscopy, repopulation of colonic microbial load is known to occur, however the qua...
The effects of different multidirectional plyometric sequences on shooting, balance, and neuromuscular performance in professional male basketball players
Objective Repeated multidirectional jumps are highly specific movements in basketball, which may be important to integrate the training routine. Accordingly, this study aimed to assess the effects of...
Characteristics of quantitative dynamic contrast-enhanced magnetic resonance imaging for orbital space-occupying lesions: A retrospective case series study
Objective This study aimed to compare the differences in the quantitative parameters of quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) across various types of orbital spac...