PLoS ONE
Articles in this Issue
β-Nicotinamide adenine dinucleotide (β-NAD) acts as a bronchodilator
Introduction β-Nicotinamide adenine dinucleotide (β-NAD) is recognized as a sympathetic neurotransmitter that relaxes vascular and intestinal smooth muscle through purinergic receptor pathways. In the...
Correction: Loss-of-function mutation of NSD2 is associated with abnormal placentation accompanied by fetal growth retardation in mice
Exposure to the organochlorine pesticide cis-chlordane induces ALS-like mitochondrial perturbations in stem cell-derived motor neurons
Amyotrophic Lateral Sclerosis (ALS) is a debilitating and incurable neurodegenerative disease with unsolved etiology. Due to the large proportion of patients lacking direct disease inheritance, unders...
Development of a decision model for the selection of exoskeletons for application in automotive production plants
This paper presents the development of a decision model for the selection of exoskeletons for application in automotive production plants. The decision model consisted of three stages: (1) Human Facto...
The impact of pulsatile vs. non-pulsatile perfusion in patients undergoing cardiopulmonary bypass: A comprehensive systematic review and meta-analysis of 33 randomized controlled trials
Background Pulsatile perfusion is a developing technique that attempts to mimic the natural pulsatile flow of blood during cardiopulmonary bypass (CBP). Purpose This systematic review and meta-analy...
Disparities and trends of the incidence and mortality of female-specific cancers in the United States
Background Female-specific cancers (FSCs) impose substantial burdens on healthcare systems and economies worldwide. The significant impact of these cancers in the United States warrants further invest...
Music genre classification with modified residual learning and dual neural network
Music Genre is an abstract property of music that can identify shared traditions and conventions. In the recent past, music genre classification has shown a significant role in MIR that has attracted...
High unawareness of kidney dysfunction in European older adults and the importance of early detection through comorbidities
Introduction Chronic kidney disease (CKD) continues to go undiagnosed at significant rates in Europe, with few exploring the underlying mechanisms which prompt detection. Considering the causal link o...
Long-term coal gangue dump regulates bacterial communities in different disturbance areas: Evidence mostly from diversity and network complexity
In order to clarify the effects of long-term coal gangue(CG) dump on the surrounding soil bacterial community structure, we selected the CG dump formed during the mining of Tunlan coal mine in Gujiao...
Stimulation of resistance genes and antioxidant enzymes in lettuce by nano metal oxides against root rot caused by Rhizoctonia solani
Root rot, caused by Rhizoctonia solani L., is becoming an increasing issue for lettuce. Nanoparticles (NPs) are emerging as a promising approach for managing biotic stress, offering advantages surpass...
Trends in the disease burden of thyroid cancer among adolescents and young adults: A comparative study of China and global estimates (1990–2021)
Objective This study aimed to assess temporal trends, epidemiological features, and sex differences in the thyroid cancer burden among adolescents and young adults, globally and in China, from 1990 to...
Correction: Development and analyses of stakeholder driven conceptual models to support the implementation of ecosystem-based fisheries management in the U.S. Caribbean
Clinical outcome of radiofrequency ablation in patients with hepatocellular carcinoma aged 80 years and older
Background and aim The incidence of hepatocellular carcinoma (HCC) is positively correlated with age, and the population of patients with HCC was also older at the time of clinical diagnosis. In the S...
New polymorph of tofacitinib citrate and in vitro equivalence study of its sustained-release tablets
Tofacitinib citrate (TOC) is clinically used primarily for the treatment of moderate to severe rheumatoid arthritis in patients who are intolerant or inadequately responsive to methotrexate. In this s...
Psychological distress and wellbeing as mediators between anti-mattering (feelings of insignificance) and irritability among Lebanese adolescents: A cross-sectional study
Background This study examined the mediating effect of psychological distress and wellbeing in the association between anti-mattering and irritability among a sample of Lebanese adolescents—a topic th...
Identification of cCMP- and cUMP-binding proteins using cCMP and cUMP coupled to agarose and biotin matrices
There is increasing evidence for a role of cyclic CMP (cCMP) and cUMP as second messengers. In a recent study we showed that cCMP activates both purified cGMP-dependent protein kinase Iɑ (PKGIɑ) and c...
Family roles and limitations as mediators in medical communication for cancer patients: A qualitative study
This qualitative study explored the role and limitations of families as mediators of medical communication among cancer patients in South Korea. Semi-structured interviews were conducted with 46 parti...
HLF gene is a poor prognostic factor in acute myeloid leukemia patients with FLT3-ITD/NPM1 mutations undergoing hematopoietic transplantation
Acute myeloid leukemia (AML) patients with FLT3-ITD mutations were benefit from hematopoietic cell transplantation (HSCT) in the first complete remission. Previous research suggested that newly diagno...
Correction: A framework for identifying calcium accumulation problem in cropland: Integrating field surveys, legacy soil map, and machine learning models
Spatiotemporal coupling and coordinated development of rural revitalization and rural tourism in Jiangsu
Rural tourism is pivotal in addressing the unidirectional urban-to-rural flow of resources, such as labor migration. However, the interaction between rural tourism and rural revitalization in develope...
Quantification of timelapse 3D tumor spheroid killing activity of NK cells using a live-cell imaging system
Natural killer (NK) cells are critical components of the immune system, responsible for recognizing and eliminating a wide range of abnormal cells, including those infected by pathogens or transformed...
Health impact and cost-effectiveness analysis of gender-neutral versus female-only 9-valent human papillomavirus vaccination in Taiwan
The prevalence of human papillomavirus (HPV)-related diseases in women has declined in countries introducing HPV vaccinations for girls but remains high among men. The objective of this study was to c...
Correction: Prognosis of extracolonic findings on clinical computed tomographic colonography: A single-center experience
Sustainable development of China’s aesthetic teaching in long-term policy changes
The construction level of the teaching staff in aesthetic education determines the education quality, and relevant policies are the guarantee for the teaching staff construction. Due to multiple facto...
Synergistic effects of sesame oil, extra virgin olive oil, psyllium extract, and dandelion extract on cholesterol gallstone dissolution: An in vitro comparative study against Rowachol®
Background Cholesterol gallstones represent a significant global health burden. Current treatments, including surgery and oral dissolution agents, are often invasive or limited by side effects and var...