PLoS ONE
Articles in this Issue
Short-duration ischemic preconditioning does not improve jump or change of direction performance in elite male handball players
This study aimed to compare the effects of a short-duration ischemic preconditioning (IPC) protocol with different cuff pressures on change of direction and jumping performance in elite male handball...
Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression
Background Acute myeloid leukemia (AML) is a malignant disorder characterized by the accumulation of immature myeloid cells which can be developed and exacerbated through inflammation. Interferon-β (I...
Development and validation of the arabic version of the social-ecological model questionnaire for patients undergoing maintenance hemodialysis
Background Patients undergoing maintenance hemodialysis (MHD) in Arabic-speaking regions, particularly in Palestine, face unique sociopolitical and cultural barriers affecting their care and quality o...
Anti-cancer activity of 7-methoxyheptaphylline from Clausena harmandiana against PANC-1 pancreatic cancer cells and its sustainable extraction method
Pancreatic cancer presents a significant therapeutic challenge characterized by poor survival rates, leading to development of innovative treatment strategies. This study evaluated the anti-cancer pot...
Immuno-informatics voyage through molecular mimicry of Heat Shock Proteins: Potential IBD immunopathogenesis
Background The interplay between the gut microbiota axis and host immunity is pivotal in the pathogenesis of inflammatory bowel disease (IBD), an idiopathic inflammatory condition. Molecular mimicry m...
Trends and disparities in dilated cardiomyopathy related mortality among adults in the United States: A CDC WONDER analysis (1999–2023)
Background Dilated cardiomyopathy (DCM) is a progressive myocardial disease characterized by ventricular dilation and impaired systolic function, often leading to heart failure and increased mortality...
Clinical and pathological implications of the presence of MECA-79-expressing tumor cells in pathological stage IA lung adenocarcinoma
Approximately 15% of patients with resected pathological stage IA lung adenocarcinoma develop recurrent disease, indicating the formation of a cancer metastasis-promoting microenvironment, and highlig...
Re-weighted estimation of the transition probability density for second-order diffusion processes
The transition probability density of second-order diffusion processes plays a fundamental role in statistical inference and practical applications such as financial derivatives pricing. This paper co...
Performance and carcass characteristics of Nellore cattle fed a high-concentrate diet with a phytogenic additive blend
This study evaluated the effects of a phytogenic feed additive – a blend of tannins, flavonoids, and essential oils – on intake, performance, and carcass traits of feedlot-finished Nellore cattle. The...
EGCN: Entropy-based graph convolutional network for anomalous pattern detection and forecasting in real estate markets
Real estate markets are inherently dynamic, influenced by economic fluctuations, policy changes and socio-demographic shifts, often leading to emergence of anomalous—regions, where market behavior sig...
Correction: Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes
Studying on the efficiency of higher education resource allocation and its influencing factors in the western China using DEA-Malmquist and Tobit models
Optimizing higher education resource allocation in western China is vital for advancing national development through education and talent. This research covers the DEA Malmquist to examine the effecti...
Expertise-driven temporal gaze dynamics during anticipation in volleyball
Perceptual-cognitive comparisons of experts and novices have consistently shown that experts use specific visual strategies to process visual scenes in their domain of expertise, reflected in eye move...
The association between serum lipid levels and colorectal cancer risk: A dose-response meta-analysis of 23 studies
Background Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and the second leading cause of cancer-related mortality. Based on recent studies, lipid levels may have a relation...
Research on the stability of the ballast water tank on the offshore floating platform based on numerical simulation
The study of stabilisation performance is a crucial consideration in the design of offshore floating platforms. For large floating structures, incorporating passive anti-roll tanks is a common techniq...
Electroacupuncture alleviates pain-like behaviors through modulating DNMT3a/MOR signaling pathway in CCI rats
Neuropathic pain (NP) affects mental health and social functioning of people. Electroacupuncture (EA) has been shown to be effective in relieving NP in clinical practice, but the specific mechanism is...
Development of a validated PROM set for children with tinnitus using the Patient-Reported Outcomes Measurement Information System – Protocol for the ‘Tinnitus in Children’ (TinC) study
Introduction Tinnitus in children remains an underexplored area of research, with limited knowledge about its prevalence and impact on daily lives. Current assessments of the impact of tinnitus in chi...
Beyond health: A machine learning analysis of structural barriers to school attainment in Somalia
In fragile states like Somalia, the link between poor health and educational exclusion is critical yet poorly understood. This study uses a novel machine learning approach to identify and rank the mos...
Evaluation of disparities in the incidence, presentation, and treatment of pediatric differentiated thyroid cancer in the United States (2000–2022)
Introduction Rates of pediatric differentiated thyroid cancer (DTC) have been increasing, yet disparities in incidence, diagnosis, and treatment across race and ethnicity have not been fully explored....
Effectiveness of the U-Niko intervention: Protocol for a cluster randomized controlled trial of a municipal-based tobacco and nicotine cessation intervention for adolescents and young adults
Introduction The use of nicotine products among youth is increasing, while existing cessation services remain underutilized. Thus, the U-Niko intervention has been developed to provide an evidence-bas...
Evaluation of nanopore sequencing for increasing accessibility of eDNA studies in biodiverse countries
Biodiversity loss is a global challenge of the 21st century. Environmental DNA (eDNA)-based metabarcoding offers a cost- and time-efficient alternative to conventional biodiversity surveys, enabling d...
Lizard polymorphic throat colors are distinguishable by conspecifics and predators across variable light environments
Color polymorphisms, or distinct color variants within a population, provide tractable study systems for studying the generation, maintenance, and loss of phenotypic diversity in nature because biolog...
Social norms and security and justice services for gender-based violence survivors in Nepal: Programmatic implications from a mixed-methods assessment
Background Gender-based violence (GBV) is highly prevalent throughout the world. Only a small fraction of survivors seek help from security and justice (S&J) providers such as the police or courts...
Association of estrogen receptor single nucleotide polymorphisms and perinatal depression
Depression during pregnancy and in the postpartum period have been receiving increasing attention considering the possible complications for the mother and baby if left untreated. Genetic variations i...
Columbia suicide severity rating scale screen scores in adults with Chiari malformation Type 1
Adult Chiari malformation Type 1 is a neurological condition characterized by high levels of chronic pain, disability, and psychological distress, yet self-harming behaviors have not previously been s...