PLoS ONE
Articles in this Issue
Comparative transcriptome analysis provides new insights into the response of common bean to infection by race 65 of Colletotrichum lindemuthianum
The farming of common beans ( Phaseolus vulgaris ) is crucial for global nutrition, culture, and economy, but the cr...
The recurrence and mortality risk in Luminal A breast cancer patients who lived in high pollution area
Luminal A is the most common subtype of breast cancer and has the best prognosis comparing to the others. The association between air pollution and survival of breast cancer have been reported but not...
New bridging eco-acoustic indices inspired by deep neural networks for fine-grained bird vocalization recognition across diurnal cycles
Revealing difference in bird vocalization changes from the perspectives of song recognition and acoustic indices has become a hot topic and challenge in recent ecological landscape research. This pape...
Clinically interpretable electrovectorcardiographic machine learning criteria for the detection of echocardiographic left ventricular hypertrophy
Echocardiographic left ventricular hypertrophy (Echo-LVH) is frequently underdetected by traditional electrocardiogram (ECG) criteria due to limited sensitivity. We investigated whether integrating EC...
Association of ABCG2 421G>T (rs2231142) Polymorphism with rosuvastatin induced adverse effects in dyslipidemic patients: Implication for personalized medicine
Statins are considered as the first line drugs for the treatment of hyperlipidemia. Despite proven efficacy of rosuvastatin, inter-individual variations in plasma rosuvastatin levels have been documen...
Minimum Dietary Diversity for Children aged 6–23 months as a predictor of micronutrient adequacy in Ethiopia: Validation of the proxy indicator
Background The Minimum Dietary Diversity for Children aged 6–23 months (MDD-C) is a proxy indicator of micronutrient adequacy. There is a lack of evidence regarding the performance of this proxy indic...
Antimicrobial stewardship programs and antibiotic use in Africa: A systematic review and meta-analysis protocol
Background Antimicrobial resistance (AMR) is a significant public health crisis, particularly in Africa where infectious disease burdens are high. While antimicrobial stewardship programs (ASPs) are a...
Experimental investigation on the physical and mechanical properties enhancement of red clay modified with “RoadyesTM”
This study investigates the enhancement of the physical and mechanical properties of red clay from the Zhuzhou region using a nano polymer material (RoadyesTM), cement, and lime. The effects of varyin...
Treatment outcomes in lower limb lymphedema misdiagnosed as iliac vein compression syndrome: A retrospective analysis
Iliac vein compression is highly prevalent in the general population, which may lead to misdiagnosis of lower limb lymphedema as iliac vein compression syndrome and subsequent stent placement. This st...
Understanding social support during pregnancy: A qualitative study of women’s lived experiences in Nepal
This research study examines the experience and understanding of available social support in Nepal and its importance during pregnancy. The interviews, utilising twenty in-depth interviews with pregna...
Cause-and-effect relationships in a nonlinear model of Bitcoin’s energy use and price volatility effect
The environmental impact of Bitcoin (BTC) has been a source of concern due to its substantial energy consumption, which is a result of its proof-of-work mining algorithm and transaction processes. The...
Evaluation of a novel virtual reality training intervention to address implicit bias among healthcare workers, using an implementation science framework
Background There is a link between racial bias and poor health outcomes among Black, Indigenous, and People of Color (BIPOC). We aimed to design and evaluate a novel pilot virtual reality (VR) trainin...
Comparative physicochemical characterization and sensory profiling of Western Algerian and Polish honeys
Background An in-depth analysis was conducted on 37 honey samples from western Algeria representing diverse floral sources—lavender, rosemary, sweet white mustard, thyme, milk thistle, carob, orange,...
Mitochondrial dysfunction-related metabolite methylmalonic acid is associated with decreased cognitive performance
Purpose Methylmalonic acid (MMA), a mitochondrial metabolite derived from propionate metabolism, has been implicated in fatal neurodegeneration in children with congenital methylmalonic acidemia. Howe...
Metabolic dysfunction-associated steatotic liver disease (MASLD) can be a possible predictive factor of incident CKD: NAGALA cohort study
Background A decade-long follow-up study identified metabolic dysfunction-associated fatty liver disease (MAFLD) as an independent predictor for the onset of chronic kidney disease...
Duloxetine and pregabalin: High-dose monotherapy or their combination?—Study protocol for a randomized trial in patients with postoperative pain after total knee arthroplasty based on the classification of central sensitization inventory scores
Background Residual pain after total knee arthroplasty (TKA) often causes patient dissatisfaction. Patients with preoperative central sensitization (CS) are especially susceptible...
Computational structural studies of SGLT2-related polypharmacy
Introduction Sodium Glucose Cotransporter 2 (SGLT2) is the main active transport protein involved in sodium and glucose reabsorption in the kidney. SGLT2 inhibitors (SGLT2i) are widely recommended for...
Depression, anxiety, and stress levels during the COVID-19 pandemic: A longitudinal study among Indonesian psychologists
During the COVID-19 pandemic, while clinical psychologists played a crucial role in supporting mental health, their well-being was overlooked compared to other healthcare professionals. Therefore, thi...
Differential regulation of the eicosanoid biosynthesis pathway in response to Enterocytozoon hepatopenaei infection in Litopenaeus vannamei
The microsporidian Enterocytozoon hepatopenaei (EHP) is a highly contagious pathogen that causes severe growth retardation in penaeid shrimp. EHP infection dama...
Development of nursing quality evaluation indicators for extracorporeal membrane oxygenation based on Donabedian theory: A Delphi study
Extracorporeal membrane oxygenation (ECMO) serves as a vital therapy for refractory severe respiratory and circulatory failure. With its expanding application in China and the heightened demand for hi...
Concordance between self-reported SARS-CoV-2 positivity and laboratory-confirmed positivity
As the use and availability of at-home antigen tests for SARS-CoV-2 infection have increased, the number of individuals with SARS-CoV-2 infections that are reported to state COVID-19 surveillance syst...
Impact of the grassland ecological compensation policy on pastoral production efficiency—evidence from pastoral China
The impact of the Grassland Ecological Compensation Policy (GECP), which protects grassland ecology while promoting the transformation and improvement of grassland animal husbandry, on pastoral produc...
Personal and perceived stigma towards mental disorders among attendants of patients with mental illness in selected health facilities of Bangladesh
The objective of this study was to explore the stigma among attendants (close relatives or other caregivers) who brought patients with mental illness to the selected mental health facilities in Bangla...
Effects of a loaded change of direction training program on physical performance in U-19 elite soccer players
Changes of direction are one of the most repeated actions during football matches, which is why the inclusion of these actions in the training of the football player must be a fundamental aspect. The...
Utility of cochlear perilymph biomarkers for hearing loss - A systematic review
The live cochlea is a critical and delicate sensory organ with tissue sampling posing a risk to balance and hearing functions. Consequently, a researchers’ ability to investigate the pathogenesis of s...