PLoS ONE
Articles in this Issue
Associations between day of admission, admission hyponatremia and hospital outcomes in medical patients: A retrospective multicenter cohort study
Introduction We investigated the relationship between admission day, serum sodium concentration, and outcomes in medical inpatients. Hyponatremia, the most common electrolyte abnor...
Challenges, innovations and considerations for the use of tongue swabs in Mycobacterium tuberculosis complex detection
Background Sputum-based testing is most used for diagnosing pulmonary tuberculosis (TB), but non-sputum specimens such as tongue swabs (TS) offer additional...
Porosity prediction from well logging data via a hybrid MABC-LSSVM model
Porosity is a key parameter for evaluating reservoir performance, but high-precision prediction is highly challenging in complex shale reservoirs due to the strong heterogeneity of the formation and t...
Effects of game-based learning and flipped classroom strategies on performance and reasoning in patient safety education for surgical nursing students
Introduction The present study aimed to assess the effect of game-based learning (GBL) on surgical nursing students’ performance and reasoning skills in the management of patient s...
User informed design of oral dispersible strips (ODS) to deliver pediatric antiretroviral therapy in Kenya: A mixed methods evaluation of product preferences and acceptability
Background Innovation to streamline the administration of pediatric antiretroviral therapy to infants and small children is urgently needed. The objective of this study was to asse...
Study on repair materials and technologies for addressing crack-related damage in the Earthen City Wall of Kaifeng
Rain and snow seepage into the cracks of the soil wall is the leading cause of its surface weathering, and the key to crack repair lies in developing reasonable repair materials. Based on the carbonat...
Protocol for a randomized controlled trial of steroid versus methotrexate as first-line monotherapy in the management of idiopathic granulomatous mastitis
Background Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease affecting mainly young to middle aged women. Its aetiology is idiopathic and poorly underst...
Research on data transaction compliance: A collaborative and co-governance approach considering buyer erroneous feedback
Data transactions are frequently hindered by compliance risks due to participants’ lack of self-regulation and the presence weak regulatory mechanism. To address seller’s non-compliant transaction iss...
MONTUR project: Dataset for understanding and forecasting tourist flows
This study presents an advanced system for monitoring and forecasting tourist flows in the Aosta Valley using distributed sensor technologies, cameras, and machine learning algorithms. This innovative...
Antibiotics utilization patterns among tertiary care hospitals in Ethiopia
Background Antibiotics are among the most used medicines globally, but antimicrobial resistance (AMR) threatens their effectiveness. The greatest mortality burden associated with A...
Evaluating phone call follow-ups in Sub-Saharan Africa: A systematic review and meta-analysis
Background Healthcare systems in Sub-Saharan Africa (SSA) face significant challenges, including limited resources, understaffing, and geographical barriers, which hinder effective...
Genomic variance in Yucatan pigs and detection of donor-derived cell-free DNA after heart transplantation
Acute rejection, one of the most devastating complications that can occur following organ transplantation, is caused by antigenic differences between the organ donor and the recipient. Following cardi...
Speed encoding in the rat striatum
The striatum plays a central role in motor control, yet how it dynamically represents variables such as locomotion speed, particularly across varying behavioral contexts, remains incompletely understo...
Can government-guided funds promote innovation output in strategic emerging enterprises? Evidence from China
Using 9,138 observations from 731 strategic emerging enterprises in China’s A-share market between 2010 and 2023, this study explores the impact of government-guided funds on innovation in these enter...
Rapid 3D phenotyping of chick embryo liver development at HH22-HH41 embryonic stages using X-ray microcomputed tomography with PTA staining
Animal models, particularly the chicken embryo (CE), remain crucial for advancing developmental biology and medicine. Liver embryogenesis, a complex and tightly regulated process, is particularly susc...
Assessment of meridic larval and adult diets for mass rearing of Bactrocera dorsalis (Diptera: Tephritidae)
The oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae), is a widespread pest in Bangladesh. Sterile Insect Technique (SIT) offers a solution for eff...
Research on emission reduction investment strategies for low carbon technology enterprises
This study investigates optimal capital allocation strategies for corporate decarbonization initiatives under technological transition constraints. A decision analysis framework grounded in real optio...
Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse
Studies of human perception have shown early cortical signals for primary information encoding, and later signals for higher order processing. An important late signal is the cortical event-related de...
Online exposure to marriage information and marriage expectations of Generation Z in China: The roles of marriage value and relative information exposure
Purpose The marriage expectations of Generation Z youth in China, the main force of marriage currently and over the next decade, are declining. In this study, several moderated med...
Identification of novel therapeutic inhibitors against E6 and E7 oncogenes of HPV-16 associated with cervical cancer
Human Papilloma Virus type 16 (HPV-16) is highly oncogenic with the E6 and E7 oncogenes playing crucial roles in the pathogenesis of HPV-related cervical carcinogenesis. Targeting these oncoproteins w...
Development and characterisation of fast dispersible dimenhydrinate tablets: Compactional study and in-silico PBPK modeling
The aim of this study was to optimize and evaluate dimenhydrinate fast dispersible tablets (50 mg) by utilizing cost effective direct compression method. A total of nine formulations (F1-F9) were desi...
Retrieval-augmented Chinese text-to-SQL generation for conversational bibliographic search
To overcome the limitations of current bibliographic search systems, such as low semantic precision and inadequate handling of complex queries, this study introduces a novel conversational search fram...
Intersecting challenges and ways forward: The impact of the COVID-19 pandemic on an urban First Nations community in Southern Ontario, Canada
The COVID-19 pandemic has had wide-ranging impacts on communities worldwide, with Indigenous communities in southern Ontario, Canada, being no exception. Partnering with Aamjiwnaang First Nation, we e...
Normative value of upper extremity Y balance test in healthy subjects aged between 18 and 36 years from South India: A cross-sectional study
Introduction The Upper Quarter Y Balance Test (UQYBT) is a validated tool used to assess unilateral upper extremity function in a closed kinetic chain. It evaluates parameters such...
“I just thought I was lucky to be protected from HIV:” Qualitative evaluation of barriers and facilitators of pre-exposure prophylaxis use for adolescent girls and young women at higher risk of HIV acquisition in Lilongwe, Malawi
Adolescent girls and young women (AGYW) are at higher risk of HIV acquisition than their male counterparts, especially in sub-Saharan African countries such as Malawi. Therefore, HIV prevention progra...