PLoS ONE
Articles in this Issue
Symptomatic dry eye disease (DED) in cohort of contact lens wearers in Jordan
Understanding the symptomatic dry eye disease (DED) and its associated risk factors among contact lens wearers is crucial for clinicians to tailor effective interventions, enhance patient care, and pr...
Regional differences in prevalence, awareness, treatment and control of hypertension in Poland - comparison of two national multi-center health surveys: WOBASZ and WOBASZ II
Introduction Data on regional differences in the current prevalence of hypertension in Poland remain limited. Objectives...
Prevalence and burden of anhedonia among patients with major depressive disorder in South Korea: A cross-sectional, observational study
Background Anhedonia (ANH), a key symptom of major depressive disorder (MDD), has a substantial societal and economic burden. In South Korea, while MDD is prevalent, the evidence r...
The German translation of the Oxford utilitarianism scale: Validation and the impact of the Covid-19 pandemic on the observations
The study of utilitarian inclinations is probably the most experimentally investigated aspect of morality. The Oxford Utilitarianism Scale has been developed to provide a self-report tool for reliable...
Comprehensive analysis of proline metabolizing genes reveals their functional diversification and abiotic stress response in Solanum lycopersicum
Proline plays a crucial role in plant stress responses. Proline metabolizing genes (PMGs) are a group of enzymes involved in its catabolism in mitochondria and the biosynthesis in the chloroplast and...
Adaptive output steps: FlexiSteps network for dynamic trajectory prediction
Accurate trajectory prediction is vital for autonomous driving, robotics, and intelligent decision-making systems, yet traditional models typically rely on fixed-length output predictions, limiting th...
Investigating the causes of casing deformation induced by faults and natural fractures in shale gas platform wells
During the development of deep shale gas in Luzhou, southern Sichuan, faults and natural fractures caused extensive casing shear deformation, including those that happen during hydraulic fracturing an...
Retraction: Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy
A lightweight zero-trust authentication architecture for IoT via unified enhanced FAST-SM9 and dynamic re-authentication
Authentication is a crucial challenge for Internet of Things (IoT) security, especially in open, distributed and resource-constrained environments. Current methods have significant shortcomings in ter...
Establishing an in vivo large animal model of one-lung ventilation and operative lung trauma
Background Respiratory complications, including acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), are important causes of morbidity and mortality among lung s...
Use of machine learning for early prediction of short-term mortality in veterans with metabolic dysfunction-associated steatotic liver disease
Background Metabolic dysfunction associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide and affects >25% in the United States populatio...
Hematological toxicity of anti-tumor antibody-drug conjugates: A retrospective pharmacovigilance study using the FDA adverse event reporting system
Background Although antibody-drug conjugates (ADCs) have shown significant efficacy in cancer treatment, hematotoxicity remains a serious issue. This study aims to investigate the...
Behavioural variability and repeatability in adult zebrafish (Danio rerio) using the novel tank dive test
Zebrafish ( Danio rerio ) are widely used in behavioural neuroscience as a model for studying anxiety-like and stres...
Minimally invasive detection of early-stage opisthorchiasis-associated cholangiocarcinoma using label-free surface-enhanced Raman spectroscopy (SERS) of hamster serum
Background Cholangiocarcinoma (CCA) is a deadly cancer often detected late. Current diagnostic methods, such as ultrasound and invasive biopsies, have limitations; there is a criti...
Analysis of engineering data with an innovative generalization of the Lomax distribution
As the amount and complexity of engineering data that need to be analyzed and interpreted continue to increase, the development of new distributions with outstanding adaptability is necessary. The aim...
Suitability of paddy cultivation in the Western province of Sri Lanka under different climate change scenarios
Climate change poses a significant threat to global agriculture, with implications for food security. Regions that rely heavily on rain-fed agriculture, especially in developing countries, such as the...
Frailty and nutritional inadequacy in older Korean adults: A gender-stratified analysis using National Survey Data
While frailty has traditionally been conceptualized through physical decline, it is increasingly recognized as a complex concept encompassing emotional, psychological, and social factors. This study e...
Computational evaluation of AKT2 mutations reveals R274H and R467W as potential drivers of protein instability and inhibitor resistance in cancer therapy
Cancer remains a leading cause of mortality worldwide, with genetic alterations such as single nucleotide polymorphisms (SNPs) playing a critical role in tumor progression and therapy resistance. Non-...
Global lessons from local contexts: The evolution of biomedicine education in Spain
Driven by the presence of faculty with research and clinical backgrounds, and by labor market trends favoring applied training, Biomedicine has emerged as a growing academic field in Spain. This study...
Correction: Factors affecting microbial safety behavior of beef handlers working in major beef retailers in Mizan-Aman, Southwest Ethiopia
Adolescents’ attitudes towards healthy eating: A scale development study
The aim of this study is to develop a measurement tool that can reliably and validly measure adolescent individuals’ attitudes toward healthy eating. The study group consisted of 1,006 individuals, in...
Phytochemical characterization and anticancer potential of Psidium cattleianum Sabine aerial parts’ n-hexane extract and its subfractions
Psidium cattleianum Sabine (Family Myrtaceae) is a Brazilian native shrub, valued for its diverse health and therapeutic attributes. The current study investig...
Prevalence and characteristics of metabolic dysfunction-associated steatohepatitis among pediatric patients in the MarketScan Databases
Introduction There are few epidemiologic studies of the prevalence of metabolic dysfunction-associated steatohepatitis (MASH) among pediatric populations....
A HAZOP-based hazard identification model for urban gas accidents: Development and empirical validation
Urban gas accidents pose significant threats to public safety and urban infrastructure, with traditional hazard identification methods often relying on manual inspections and experience-based judgment...
Prediction of immunogenicity of Rh antigens using in silico analysis of binding to human leukocyte antigen peptide, Basic/Translational Research
The association between human leukocyte antigen (HLA) types and blood group alloimmunization remains unclear. Previous studies have predominantly focused on predicting immunization events in cancer im...