PLoS ONE
Articles in this Issue
Self-reported infertility and longitudinal measures of cardiovascular risk factors: The CARDIA study
Introduction Previous reports have noted associations between infertility in women and increased risk of cardiovascular disease (CVD) events in later life. However, reports conflic...
Associations of serum pepsinogen and Gastrin-17 with Helicobacter pylori infection, sex, and age, in an asymptomatic coastal population: A cross-sectional study in Rizhao, China
Background Pepsinogen (PG) and gastrin-17 (G-17) are widely used in the screening of gastric diseases. Our cross-sectional clinical study investigates the re...
Effect of music therapy on sleep quality in elderly: A systematic review and meta-analysis
Background Sleep disturbances are common among older adults, affecting up to 50% of this population and significantly impacting quality of life and health outcomes. Music therapy h...
The 3N Model and collective support for extreme measures to combat COVID-19
Understanding resistance to COVID-19 measures is crucial, since it undermines public health efforts during crises. Building on prior research showing the crucial role of individual psychological facto...
The efficacy and safety of lignocaine-embedded dissolvable microneedle versus EMLA for topical analgesia in adults undergoing venepuncture: A single-centre, parallel-group, double-blind randomised clinical trial protocol in a tertiary care setting
Venepuncture-associated pain is a major source of distress commonly experienced by adult patients in day-to-day clinical practice. Topical lignocaine application before venepuncture may address this i...
Time to phlebitis onsite and its predictors among admitted patients with peripheral intravenous cannulas at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia, 2024/ 2025: A prospective follow-up study
Introduction Phlebitis due to peripheral intravenous cannulation is a common issue in hospitalized patients which leading to serious complications such as deep vein and pulmonary t...
Nonlinear dynamics of curve-face gear transmission systems in two-parameter plane
To systematically investigate the nonlinear dynamic characteristics of curve-face gear transmission systems and the influence of key parameters on their dynamic behavior, this study established a 6-de...
Detection and characterization of human bocaparvovirus in children with and without acute gastroenteritis in African-descendant community of Northern Brazil
Human bocaparvovirus (HBoV) is an emerging virus with worldwide distribution, may be associated with cases of acute gastroenteritis (AGE). To date, four types of HBoV have been characterized: HBoV1, H...
The relationship between the neutrophil percentage to albumin ratio and the occurrence of prostate cancer
Background Although prior research has indicated that nutritional and inflammatory markers may play a role in prostate cancer development, the exact interplay and underlying mechan...
Two-stage cluster sampling to assess SARS-CoV-2 seroprevalence without pre-enumeration: An example from Madagascar
Implementing population-based surveys in resource-constrained settings presents logistical challenges when detailed population enumeration is unavailable. We developed a field mapping system integrate...
Effect of dopamine on TGF-β2 secretion by human retinal pigment epithelial cells and the underlying mechanism
Background Dopamine is known to play a role in the development of myopia. In this study, we investigated the effect of dopamine (DA) on the secretion of transforming growth factor-...
Harnessing genetic diversity: The genomic and transcriptomic insights of Eugenia uniflora for environmental resilience
Pitanga ( Eugenia uniflora L.), a member of the Myrtaceae family, is native to the Brazilian Atlantic Forest and distributed across various ecological environme...
Effect of silver and graphene nanoparticles on the thermophysical performance of ethylene glycol-glycerol hybrid nanofluids
This study examines the thermophysical properties of ethylene glycol–glycerol (60:40 v/v) hybrid nanofluids containing graphene nanoplatelets (GNPs) and silver nanoparticles (Ag) at concentrations of...
Occupational risk of COVID-19 related hospital admission in Skåne, Sweden: A register-based cohort study
Purpose Given the paucity of data regarding workplace risk of COVID-19, particularly from countries with limited lockdowns, we aimed to quantify the occupational risks of COVID-19-...
Abdominal computed tomography–assessed muscle quality and its prognostic value in patients with advanced chronic kidney disease initiating hemodialysis
Background Skeletal muscle density (SMD), assessed via L3 level computed tomography (CT), is a critical marker of muscle quality with remarkable prognostic value in various clinica...
Prevalence and determinants of anemia among HIV-positive children in central Uganda: A cross sectional study
Background Anemia remains a critical public health issue, especially in low-resource settings like Uganda, with severe consequences especially in HIV-positive children. Limited res...
Evaluation of a new implant for Tibial Tuberosity Transposition in dogs: An ex vivo study
The present study aims to describe and evaluate the effectiveness and potential applicability of a new implant designed to transpose the tibial tuberosity. The implant consists of a customized plate f...
Green synthesis of silver nanoparticles from Brownlowia tersa leaf extract: multifaceted evaluation of antibacterial, antioxidant, cytotoxic, and anti-alzheimer potential
This study reports the first green synthesis of silver nanoparticles (AgNPs) using an aqueous leaf extract of Brownlowia tersa ( B. tersa...
Study on crude oil displacement efficiency by fracturing fluid in tight sandstone reservoir
Tight sandstone reservoirs usually experience a long flowback period after hydraulic fracturing, which significantly affects oil production. After fracturing, the well-soaking is commonly employed to...
Effects of COVID-19 pandemic lockdowns on college students’ physical fitness: A comparative study
Background The impact of the COVID-19 outbreak has been significant and far-reaching. This paper retrospectively examines its effects on changes in the physical fitness of universi...
Long-term potentiation and neurotransmitters expression and segregation are altered in the Metabolic Syndrome-associated dysautonomia
The autonomic nervous system (ANS) dynamically regulates the internal environment to maintain homeostasis. The ANS exhibits some forms of synaptic plasticity, including long-term potentiation (LTP) an...
Adolescent morphine exposure does not alter low-dose lipopolysaccharide (LPS)-induced sickness behavior in adult C57/BL6 mice
Adolescent opioid use in the United States commands attention: millions of twelve- to nineteen-year-olds are exposed to opioids each year by prescription and misuse. Recent findings show that opioids...
Molecular diagnosis of Trichuris trichiura: Prevalence and associated risk factors in children under five living in a malaria-endemic area in Papua, Indonesia
Background Trichuris trichiura , a soil-transmitted helminth (STH), infection is highly prevalent in children and, if not treated, can...
Construction and validation of an anoikis-related prognostic model for lung adenocarcinoma based on bulk and single-cell transcriptomic data
Lung adenocarcinoma (LUAD) is a highly aggressive lung cancer with poor prognosis due to lack of reliable biomarkers. Resistance to anoikis drives tumor progression and metastasis. This study aims to...
Which demographic characteristics are associated with willingness to take part in recontact studies? A cross-sectional study
Background Lower rates of participation in research by ethnic minority groups and socioeconomically deprived populations has led to efforts to develop recruitment strategies which...