PLoS ONE
Articles in this Issue
Integrating genomic epidemiology and deep mutational scanning data for prevalence forecasting of SARS-CoV-2 Omicron lineages
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continuously circulates and the Omicron variants have mutated into over 2,500 lineages, predicting ensuing prevalent lineages and inflectio...
A thematic analysis of flu vaccine hesitance in ethnically minoritised communities in Liverpool
Background Seasonal influenza causes around 15,000 deaths yearly in the United Kingdom. Low vaccine uptake is more prominent in ethnically minoritised communities and deprived area...
Cancer Prevention at Work (CPW) project: Rationale, framework and research protocol
Chronic infections such as Helicobacter pylori (Hp), Hepatitis C virus (HCV), and Human Papillomavir...
Novel pyrimidine-substituted chalcones: In vitro antioxidant properties and cytotoxic effects against human cancer cell lines
A series of novel pyrimidine-substituted chalcones were synthesized, purified, and characterized. Four selected compounds ( CFMPY 4, 15, 17, and 28 ) exhibited...
Antimicrobial multidrug resistance of Escherichia coli from broiler farms in Zhanjiang, China
Guangdong Province is an important area of poultry breeding in China. Zhanjiang city is located in the western part of Guangdong Province, where there are many broiler farms. To investigate antimicrob...
Roll-to-roll manufacturing of flexible acetone sensors
A fully roll-to-roll (R2R) manufactured conductometric sensor has been developed for acetone detection. It features flexible, screen-printed silver electrodes modified with a MoS2 and single-walled ca...
Cytoarchitectural modifications and antiinflammatory strategies in tendinopathy recovery
Tendinopathies (TPs) are complex conditions marked by inflammation, pain, and impaired function, often due to tendon overuse. Achilles tendinitis, a prevalent TP, affects both athletes and the general...
Exploring the genetic landscape of the Copper Homeostasis and Silver Resistance Island (CHASRI) in Salmonella enterica
Copper is essential for all living organisms, but becomes toxic when present in excess. Biological systems have evolved mechanisms to keep organisms in copper homeostasis. Studies have shown that...
Heart failure induced by isoproterenol: A comparison of two doses and two delivery methods in C57BL/6J mice
Heart failure (HF) modeling requires standardized protocols to ensure translational relevance. Despite the widespread use of isoproterenol (ISO)—a β-adrenergic agonist—in HF modeling, methodological i...
Who gets what, where: To what extent are inequalities in distribution of Norwegian child welfare service measures related to spatial and temporal variation
Inequality has long been a persistent issue, but it has intensified since the turn of the millennium and is now considered one of the most urgent challenges of our time. Even in Norway, which is tradi...
Estimating psychophysiological loads by repeated temperature steps on humans using a state–space model
Humans are exposed to daily temperature differences indoors and outdoors worldwide; however, the associated risks to health and fatigue remain unclear. This study aimed to clarify the psychophysiologi...
Lookback supports semi-parallel, just-in-time processing in second language written composition
Purpose Competent written production results from semi-parallel processes that flow from content determination to finger movement. Information from upstream processes that is not u...
Chinese music teachers value effectiveness, social, and facilitating factors over ease of use in ICT integration: A PLS-SEM study
The integration of information and communication technology (ICT) in education has been widely acknowledged for its potential benefits. However, there is limited understanding of the factors influenci...
Ultraviolet–visible spectral characterization and ANN modeling of aqueous sugar solutions: Clinical and environmental perspectives
The characterization of aqueous sugar solutions using optical techniques offers a non-invasive, rapid, and reagent-free approach for concentration monitoring in both analytical and environmental conte...
Evaluation of the novel HEalthy Lifestyle Project (HELP) youth mental health e-intervention for lifestyle behaviour change and mental healthcare system impact: A randomized controlled trial protocol
Background Youth mental health is in crisis: suicide and self-harm doubled from 2019–2022; youth wait 8–12 months for care; 75% of youth with mental illness do not get care. Sleep,...
Performance and tolerance of Moringa stenopetala exposed to drought stress during germination and growth
Moringa stenopetala is a rapidly growing, unappreciated tree regarded as the “miracle tree” for its food, feed, and medicinal benefits. It appears to be a versatile and promising s...
Evaluating the effectiveness of the “Double Reduction” education policy in China: A study using web scraping, sentiment analysis, and spatial regression
Background The implementation of China’s “Double Reduction” (DR) policy, which aims to alleviate academic and extracurricular burdens, has received considerable attention. However,...
Co-development of an acceptance and commitment therapy-based intervention to increase intrinsic motivation of adolescents to change weight: The AIM2Change study
Childhood obesity levels continue to rise, with significant impact on individuals and the NHS. The ‘Complications of Excess Weight’ (CEW) clinics provide support to young people with complications of...
Changes in haematological indices among children with sickle cell disease on hydroxyurea treatment for at least 1 year: A cohort study
Background Sickle cell disease is the 12 th cause of under-five mortality in Africa, with over 81,000 deaths attr...
Sequestration and suppressed synthesis of oncogenic HMGA1 using engineered adenoviruses decreases human pancreatic and breast cancer cell characteristics
HMGA1, an architectural transcription factor that plays a crucial role in tumorigenesis, chemotherapy resistance and cancer stem cell transformation in many human cancers, is intrinsically disordered...
Correction: Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
Effects of seated Tai Chi Yunshou on upper limb function among stroke patients in the subacute phase: A study protocol for a randomized controlled trial
Background Upper limb dysfunction after stroke is one of the common problems. Tai Chi Yunshou exercise and seated Tai Chi exercise have been confirmed that it is beneficial on uppe...
Identification of Seven in absentia homolog 2 as a potential efferocytosis-related biomarker in diabetic foot ulcers
Introduction Wound of diabetic foot ulcers (DFU) is chronic and hard to heal, characterized by impaired inflammatory response, dysfunction of keratinocyte and endothelial cells and...
Assessment of DNA damage of smooth muscle cells in tunica media of human arterial allografts using Comet assay method
During the harvest and subsequent processing of blood vessels for allogeneic transplantation, DNA damage can occur. A suitable method for quantifying this damage may be the comet assay, also known as...
Research to evaluate safety and impact of long COVID intervention with Ensitrelvir for National Cohort (RESILIENCE Study): A protocol for a randomized, double-blind, placebo-controlled trial
Long COVID, characterized by persistent symptoms following acute coronavirus disease (COVID-19), presents a substantial challenge to global health. Ensitrelvir fumarate, a novel oral antiviral agent,...