PLoS ONE
Articles in this Issue
An osteoporosis course as a separate component of problem-based learning
The objective was to compare the extent of acquired knowledge regarding osteoporosis-related issues in a group of medical students who successfully completed an optional “Elective Osteoporosis Course”...
Comprehensive bioinformatic analysis of HTR7: A potential biomarker for diagnosis, survival, and immunotherapy in pan-cancer
We used several public databases to perform a comprehensive pan-cancer analysis to determine the potential role of HTR7 in diagnosing tumors, predicting prognosis, and predicting cancer immunotherapy...
First-principles calculation of adsorption of cadmium and lead on the surface of a 1T-MnO2 monolayer
Manganese dioxide is a material with varied and interesting applications, especially including energy storage, the elimination of organic contaminants, and the removal of toxic atoms and molecules tha...
Community engagement in Indigenous food systems contamination studies: A systematic scoping review
Introduction Indigenous food systems are vital for maintaining cultural practices, physical and mental well-being, and community health. However, these systems are increasingly thr...
The efficacy of Pembrolizumab, Ipilimumab, and Nivolumab monotherapy and combination for colorectal cancer: A systematic review and meta-analysis
Background Colorectal cancer ( CRC ) is the third leading cause of cancer-related deaths wo...
Mediterranean Diet reduces ischemic heart disease risk in diabetes patients until reversed by smoking: Evidence from UK Biobank cohort
Objectives This study aims to explore the association between the Mediterranean Diet (MD) pattern and the development of ischemic heart disease (IHD) in patients with diabetes mell...
Modeling the impact of cochlear nerve degeneration on speech recognition performance
Cochlear nerve degeneration (CND), including the loss of synapses between inner hair cells and auditory nerve fibers (ANFs), has emerged as a likely contributor to “hidden hearing loss”, a condition i...
Intervallic intonation: Applying the Implication-Realization model of musical melody to speech intonation and prosody
This methodological study presents the Implication-Realization (IR) model as a framework for the analysis of linguistic prosody and examines its application to English-language examples of speech. Ori...
Assessing changes in the availability and readiness of health facilities to provide modern family planning services in Bangladesh: Insights from Bangladesh Health Facility Surveys, 2014 and 2017
Background Modern family planning plays a vital role in reducing unintended pregnancies, a major reproductive health issue worldwide. Access to modern family planning services is e...
The impact of diagnosis-intervention packet (DIP) payment on cost structure of inpatient care—Evidence from a tertiary hospital in China
Background Since 2020, China has implemented DIP (Diagnosis-Intervention Packet) payment reform to control medical costs and reduce patient financial burden. The reform was piloted...
MSF-DETR: A small target detection algorithm for sonar images based on spatial-frequency domain collaborative feature fusion
Side-scan sonar imaging is essential for underwater target detection in marine exploration and engineering applications, yet small target detection faces significant challenges including limited frequ...
Synergistic enhancement of AAV gene delivery in 2D cells and 3D organoids using polybrene and hydroxychloroquine
Recent advances in three-dimensional (3D) culture platforms have enabled organoids to serve as physiologically relevant models for recapitulating human biology and assessing therapeutic efficacy and t...
Integrating national open databases for a comprehensive view on food systems, environment sustainability and health in Brazil
This paper details the integration of open-source databases on food production and consumption, pesticide use, water and land use, and nutrient supply, segmented by year and region. The process of ext...
Determinants and group differences in international undergraduates’ engagement in Chinese higher education
Student engagement is a crucial indicator of academic success, quality education, and overall development, encompassing behavioral, cognitive, and emotional dimensions. This study aimed to investigate...
Art-induced psychological well-being: Individual traits shape the beneficial effects of aesthetic experiences
Since the beginning of the last century, a wide variety of studies have provided evidence of the role of art in improving health and well-being. In this study, we engaged 92 young adults in a guided t...
Predicting 30-day and 1-year mortality in heart failure with preserved ejection fraction (HFpEF)
Objectives To develop and compare prediction models for 30-day and 1-year mortality in Heart failure with preserved ejection fraction (HFpEF) using EHR data, utilizing both traditi...
Early disruptions in vitamin D receptor signaling induces persistent developmental behavior deficits in zebrafish larvae
A critical function of the nervous system is to rapidly process sensory information and initiate appropriate behavioral responses. Defects in sensory processing and behavior selection are commonly obs...
Characterisation and sustainability evaluation of cereals and pulses formal seed production systems in Cameroon
Cereals and pulses are essential commodities for human nutrition in Africa. Seed quality is the vital input and precondition for good agricultural production. Good seeds are mainly supplied by the for...
Genetic correlation analysis between sepsis and hematological traits: Identifying shared genomic regions
Background Sepsis, dysregulated cascades of inflammatory response to infection, remains a critical clinical condition, leading to morbidity and mortality. Better understanding of t...
Development of SSR markers related to salinity resistance based on transcriptomic sequences in Medicago sativa
Alfalfa ( Medicago sativa ) is an important perennial forage crop that exhibits wide cultivar variations in salinity tolerance. Simple sequence repeats (SSRs) i...
Towards an optimized paradigm: generative adversarial networks and 3D modeling in landscape design and generation
Virtual reality (VR) integrates technologies like computer graphics, artificial intelligence, and multi-sensor systems, creating transformative tools for designers and users. This study proposes a nov...
The mediating role of blood metabolites in the association between myocardial infarction and cancer risk: An observational and mendelian randomization analysis
Background Myocardial infarction (MI) and cancer are major global public health challenges. Research indicates that they share common risk factors and that physiological changes fo...
Environmentally friendly polymers are used to enhance the water retention capacity of waste residue and the potential for vegetation growth
The large pores and lack of water storage capacity limit the ecological rehabilitation of the waste residue. Modified hydrophilic polyurethane (W-OH) was used to improve the water retention of the res...
Correction: Correction: Effectiveness and satisfaction of mindfulness-based cognitive therapy for children on anxiety, depression, and internet addiction in adolescents: Study protocol for a randomized control trial
Prevalence of extended spectrum β-lactamase and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in raw bulk cow milk from dairy cooperatives, Northwest Amhara, Ethiopia
Introduction Extended spectrum β-lactamase (ESBL) and carbapenemase-producing Escherichia coli (...