PLoS ONE
Articles in this Issue
Impact of processing and analysis methodology on thalamic susceptibility assessment in multiple sclerosis
Background Studies using quantitative susceptibility mapping (QSM) to investigate thalamic iron levels in people with multiple sclerosis (pwMS) have yielded inconsistent results. I...
Dosimetric divergence in ICBT vs. IC/ISBT configurations: Comparative analysis of three optimization algorithms for cervical cancer brachytherapy
Objective To compare dosimetric differences among graphical-based manual planning (MA), simulated annealing inverse optimization (IPSA), and hybrid inverse optimization (HIPO) for...
Simultaneous quantification of rDNA methylation and copy number: Constraints to natural variation in humans and cell lines
Ribosomal DNA (rDNA) copy number (CN) varies widely both across and within species. In humans, it has been hypothesized that rDNA transcriptional activity is partially regulated by rDNA methylation st...
The impact of latent tuberculosis screening programmes for migrant populations in high income, low burden countries
Background Migrants from high to low tuberculosis (TB) incidence countries may benefit from screening for latent TB infection (LTBI), but the optimal approaches and effectiveness a...
Red cell distribution width and associated factors among hypertensive patients attending Arba Minch General Hospital, Southern Ethiopia: A comparative cross-sectional study
Background Red cell distribution width (RDW) has been increasingly linked with cardiovascular and metabolic conditions. However, its clinical relevance in hypertension remains unde...
Unveiling the trophic dynamics and ecological roles of demersal fish in Hong Kong: A metabarcoding and isotope analysis approach
This study provides a comprehensive examination of the trophic ecology and feeding dynamics of 16 demersal fish species inhabiting the southern and southwestern waters of Hong Kong, utilizing advanced...
Predictors of shared decision-making among treatment-seeking emerging adults in primary care and community addiction and mental health settings: A cross-sectional study
Background Shared decision-making (SDM) is a process in which healthcare providers (HCPs) and patients make health-related decisions collaboratively, guided by the best available e...
CattleNet-XAI: An explainable CNN framework for efficient cattle weight estimation
Accurate estimation of cattle weight is essential for effective farm management, health assessment, and productivity optimization. Traditional manual methods for weight estimation, however, are labor-...
Prognostic role of effective radiation dose to immune cells in esophageal cancer treated with definitive chemoradiation
Background Radiotherapy for locally advanced esophageal cancer can induce lymphopenia, potentially worsening outcomes. This study examines the association between clinical outcomes...
Deciphering oxidative stress contributions in vestibular schwannoma: A bioinformatics approach to novel therapeutic pathways
Background Vestibular schwannoma (VS) is a benign tumor originating from Schwann cells, and its molecular pathogenesis remains poorly understood. Increasing evidence suggests oxida...
Processes for creating an interprofessional mental health identity among pre-registration healthcare students: A scoping review protocol
Background Developing an interprofessional mental health identity among pre-registration (licensure) healthcare students is critical for promoting effective interprofessional colla...
Closed-loop temperature management with internet of things technology support in elderly laparoscopic rectal cancer surgery: A randomised controlled trial
Background This study investigates the effectiveness of closed-loop temperature management supported by Internet of Things technology in elderly patients undergoing laparoscopic re...
Exploring physical activity and patient perceptions in knee osteoarthritis: A mixed-methods study
Knee osteoarthritis (KOA) is a prevalent condition that reduces physical function and quality of life. Physical activity is foundational to KOA management; however, patient engagement and perceptions...
Synthesis of 3-(arylamino) quinazoline-2,4(1H,3H)-dione derivatives via TBHP/I2: Molecular docking, MD simulation, DFT, and pharmacological evaluation as MTH1 inhibitors
A series of novel derivatives of 3-(arylamino) quinazoline-2,4(1 H ,3 H...
Flexible joints performance assessment of additive manufacturing FDM 3D printed TPU
Given the increasing adoption of flexible 3D-printed joints in the field of robotics, it is essential to characterize the stiffness/spring coefficient and damping of printed specimens to understand th...
Multiscale study of memory type simple ratio estimators in two stage sampling under exponentially weighted moving averages
Two-stage cluster sampling is often employed in survey sampling when complete population information is not available. In this setting, the Exponentially Weighted Moving Average (EWMA) statistic offer...
Structural and immunological impacts of TOLLIP nsSNPs: A computational biology approach to drug discovery and immune system modulation
Toll-Interacting Protein ( TOLLIP ) serves as key adaptor molecule in innate immune signaling, modulating toll-like receptors (TLRs) and interleukin-1 (IL-1) pa...
The limits of action control for deceptive actions in sports: Response inhibition for the basketball pump fake
Even NBA players fall for pump fakes in approximately 73% of the time and initiate erroneous blocking movements. To investigate the spatio-temporal and dynamic constraints of inhibition performance in...
An assessment of a health education program addressing overweight, obesity and lifestyle modification in Ghana
Background Obesity is a significant risk factor for several comorbidities, including type II diabetes, cancer, and cardiovascular diseases. Recent studies suggest an increase in th...
The impacts of project uncertainty and relationship conflict on relationship continuity in construction: The role of political skill
Project uncertainty is a common feature in construction projects, and relationship conflicts often arise from interactions among project partners. This study examines the negative effects of project u...
DSSA-TCN: Exploiting adaptive sparse attention and diffusion graph convolutions in temporal convolutional networks for traffic flow forecasting
Accurate traffic flow forecasting is essential for intelligent transportation systems, yet the nonlinear and dynamically evolving spatio-temporal dependencies in urban road networks make reliable pred...
Written or oral? The impact of social network relationships on land transfer contract choices: Evidence from the latest survey data in China
Facilitating the transfer of rural land is a significant initiative by the Chinese government aimed at optimizing the allocation of land resources and promoting agricultural modernization. Among these...
Photo-voicing experiences of teenage mothers with teenage pregnancy and motherhood in Western Uganda
Teenage Pregnancy and Motherhood (TPM) pose significant global public health challenges, particularly in Sub-Saharan Africa with Uganda being among the countries most affected. In this phenomenologica...
Correction: Adaptive political surveys and GPT-4: Tackling the cold start problem with simulated user interactions
A simplified approach to failure analysis of ball bearings combining Principal Component Analysis and Fast Fourier Transform
Ball bearing monitoring employs time-frequency techniques to facilitate the early detection of faults; however, the presence of non-stationary or noisy signals can limit the effectiveness of these tec...