PLoS ONE
Articles in this Issue
Transforming tropical peatland governance to manage climate risks using the Three Horizons method
Tropical peatlands occupy at least 440,000 km 2 and are estimated to store around 100 megatons of carbon, but are exposed to risks from both current and anticip...
Molecular characterization of Rhipicephalus microplus and Haemaphysalis bispinosa ticks from cattle across Thailand: Regional identification and evidence of different genetic sub-structures between mainland and peninsular populations
Phylogenetic and population genetic analyses were conducted on tick specimens collected from cattle in northern, northeastern, central, and southern regions of Thailand. Morphological identification i...
Dysbiosis of gut microbiota in C57BL/6-Lepem1hwl/Korl mice during microplastics-caused hepatic metabolism disruption
The oral administration of microplastics (MP) for 9 weeks induced disruption of hepatic lipid, glucose, and amino acid metabolism in C57BL/6-Lep em1hwl /Korl (L...
The use of implementation strategies to promote the uptake of psychological therapies among people with multiple sclerosis: A scoping review protocol
Objective This paper aims to standardize a scoping review protocol for completion of a scoping review. The proposed scoping review aims to: 1) determine the extent of the literatur...
Serology change-based clinical interpretation of indeterminate serostatus post-hepatitis B virus infection in people living with HIV
After hepatitis B virus (HBV) infection in people living with HIV (PLWH), various forms of indeterminate serostatuses, including “isolated anti-HBc (IAHBc)”, are observed, but the current interpretati...
Origins of the hydrothermal dolomites in Middle Permian, Sichuan Basin (SW China): Implication for the relationship with the Emeishan Large Igneous Province
The Middle Permian dolomites in the Sichuan Basin (SCB) of China include several replacive phases and pore-filling saddle dolomite (Rd3 and Sd). This study investigates the origin of the main hydrothe...
Dietary fiber inulin mitigates peripheral neuropathy in different stages of diabetes via modulating gut microbiota and metabolites in db/db mice
The pathogenesis underlying diabetic peripheral neuropathy (DPN) remains largely elusive. Due to current unsatisfactory therapeutic approaches, new strategies for the control of DPN are needed. The pr...
Personalized video-based health education after ischemic stroke: A single-center cross-sectional study in China
Background and objectives Health education can help patients engage in evidence-based healthy behaviors, and the construction of smart hospitals can promote accurate video-based he...
BCG cell wall skeleton augments the immunogenicity of dengue nanoparticle vaccines by promoting dendritic cell activation
Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) has been shown to enhance vaccine effectiveness and antitumor immunity. In our previous study, we reported that co-administration of BCG-CWS with...
Forecasting urban air quality in Paris using ensemble machine learning: A scalable framework for environmental management
Urban air pollution poses a significant threat to public health and urban sustainability in megacities like Paris. We cast forecasting as a short-term, next-hour prediction task for PM2.5, NO, and CO,...
Standard language proficiency as social capital: Impacts on subjective socioeconomic status in China
Although language proficiency—especially in a standard language—has been widely studied as an indicator of social status and mobility, its relationship with subjective socioeconomic status (SES) requi...
Outcome of infants with bronchopulmonary dysplasia
Background Bronchopulmonary dysplasia (BDP) is the most common chronic lung disease in infants. The study aimed to evaluate the outcome of infants diagnosed with BPD in Yogyakarta,...
Persistent low-density infection in areas at risk of malaria reintroduction in Malaysia
Malaysia successfully achieved zero indigenous human malaria cases since 2018. However, challenges persist from Plasmodium knowlesi (zoonotic malaria) and low-d...
Multispecific antibodies: Bioanalytics for early-stage screening and characterization of mispairing profiles
Multispecific antibodies (MsAbs) enable the targeting of different epitopes, representing a strategy with enhanced therapeutic potential. However, the intracellular assembly of MsAbs is complex and ge...
Integrated knowledge translation (iKT) in preclinical research: A scoping review protocol
Introduction Integrated knowledge translation (iKT) is a collaborative research approach that emphasizes the meaningful and active participation of knowledge users throughout the r...
Evaluation of imputation strategies for multi-centre studies: Application to a large clinical pathology dataset
As part of a strategy for accommodating missing data in large heterogeneous datasets, two Random Forest-based (RF) imputation methods, missForest and MICE were evaluated along with several strategies...
Controlling worm propagation in wireless sensor networks: Through fractal-fractional mathematical perspectives
Wireless Sensor Networks (WSNs) are particularly vulnerable to malware attacks due to their limited processing power, memory, and energy, which makes defending against such threats especially challeng...
Using machine learning for detection of Parkinson’s disease and mild cognitive impairment
Background Parkinson’s disease is a movement disorder featuring motor symptoms and cognitive decline, which can manifest as mild cognitive impairment. The incidence of mild cogniti...
Healthcare providers’ perceptions of changes in guidelines for care of minors with gender dysphoria in Sweden: An interview study
Background The number of youths seeking care for gender dysphoria has increased globally over the last ten years. In December 2022, the Swedish National Board of Health and Welfare...
IFRS 9 and procyclicality of loan loss provision among Chinese regional banks, the role of local leaders’ turnover
This research aims to investigate the impact of IFRS 9 adoption on the procyclicality and the role of the local leaders’ turnover in this relationship. The financial accelerator theory and institution...
Scalp haircuts, keloids and blood-borne virus transmission risk in South Africa—The SHAKA study
Background The most frequent transmission modes of blood-borne infections (BBI), including HIV, hepatitis B virus (HBV) and C (HCV), are well documented. Sou...
The seen and be heard study: A national mixed methods study to identify the barriers and facilitators to ensuring equitable cancer care for children with and without learning disabilities and/or who are autistic – Protocol Paper
Introduction A strong body of evidence exists relating to inequality in general healthcare experience and outcomes for children and young people with learning disabilities and/or w...
Study Protocol of SURVIVE HERoes (NCT06643585): Trastuzumab Deruxtecan for molecular relapse in HER2+/ Low early breast cancer with ctDNA positivity after primary therapy
Background Current evidence on circulating tumor DNA (ctDNA) in the adjuvant setting of early breast cancer (eBC) confirms its high prognostic value. CtDNA-positive patients withou...
Exploring drivers of modern Hanfu purchase in digital commerce: A mixed-methods perspective
The rapid growth of the modern Hanfu market, driven by digital commerce and social media, has increased the interest in understanding consumer purchase intentions. This study investigates the key fact...
Integrated analysis of genome, metabolome, and transcriptome reveals a bHLH transcription factor potentially regulating the accumulation of flavonoids involved in carrot resistance to Alternaria leaf blight
Resistance of carrot to Alternaria leaf blight (ALB) caused by Alternaria dauci is a complex and quantitative trait. Numerous QTL for resistance (rQTLs) to ALB...