PLoS ONE
Articles in this Issue
Protocol for a systematic review and meta-analysis of the impact of cervical cancer prevention initiatives in Ghana
Background Cervical cancer, though preventable, remains the second most diagnosed cancer and the primary cause of cancer-related deaths among females in Sub-Saharan Africa. The sig...
Associations of perceived neighborhood factors and Alzheimer’s disease polygenic score with cognition: Evidence from the Health and Retirement Study
Background We examined the relationships between neighborhood characteristics, cumulative genetic risk for Alzheimer’s disease (polygenic scores for Alzheimer’s disease), and cogni...
Exploring factors contributing to patient decision-making in the care journey to elective hernia care in Kenya
Background Capacity for elective general surgical care is an important reflection of a health system’s ability to meet a population’s surgical needs and is currently known to be in...
Reproduction of porcine ear necrosis (ear-tip necrosis) following intradermal inoculation of pigs with Fusobacterium necrophorum
Porcine ear necrosis (PEN) (also referred to as ear-tip necrosis, ETN) is a syndrome of global presence and unclear aetiology. Initially reported in the 1950s, many different infectious and non-infect...
Cross-modal fusion of brain imaging and clinical data for Parkinson’s disease progression prediction
Background: Machine learning shows great potential in science but struggles with complex, high-dimensional multi-omics data. PD progression is long, diagnosed mainly by clinical si...
N-glycosylation of NANOG regulates stemness and apoptosis in colon cancer cells
To investigate the effect of N-glycosylation on NANOG regulation of colon cancer stem cell characteristics. The GEPA database was used to screen and analyze the expression of N-glycosylase in colon ca...
Albumin-corrected anion gap as a predictor of 28-day mortality in acute respiratory distress syndrome: A machine learning-based retrospective study
Background Acute Respiratory Distress Syndrome (ARDS) remains a critical condition associated with high mortality rates, prolonged hospitalization, and reduced quality of life desp...
Downregulation of serum vitamin D receptor level, serum 25-hydroxyvitamin D, and association of vitamin D receptor gene polymorphisms ApaI and TaqI with obesity in the Bangladeshi population
Background/Objectives Obesity is a chronic metabolic disorder, and its prevalence in Bangladesh is increasing at an alarming rate. Previous reports have suggested a significant ass...
Research on partial discharge signal recognition and classification of power transformer based on acoustic-VMD and CNN-LSTM
Partial discharge (PD) detection in power transformers is critical for preventing insulation failures in modern power grids, yet remains challenging due to signal complexity and environmental noise. E...
Female genital mutilation and its effects among women of reproductive age in Kenya: Insights from Kenya Demographic and Health Survey 2022
Introduction Female genital mutilation (FGM) is a significant public health issue rooted in cultural traditions, affecting millions of women and girls. In Kenya, the practice is pr...
Detection performance of an X-band marine radar system for free-flying Asian particolored bats (Vespertilio sinensis)
The rapidly growing number of wind farms is an increasing threat to many bat species and populations worldwide. Monitoring and prediction of bat collision risk requires techniques capable of quantifyi...
A qualitative study exploring motivations for participating in research among women who use opioids
Objectives We assessed the acceptability of four recruitment strategies and explored facilitators and barriers to research engagement among women who use opioids....
The rise and fall of religion: An agent-based model of secularisation, security and prosociality
The relationship between religion, society, and individual behaviour has been a subject of extensive inquiry, drawing upon a rich collection of historical and contemporary perspectives. The scientific...
5-hydroxymethylcytosines from circulating cell-free DNA as noninvasive prognostic markers for gastric cancer
Background Prognostic assessment plays a crucial role in guiding clinical management and treatment decisions for gastric cancer patients. The enrichment characteristics of 5-hydrox...
Analyzing the influence of mobile internet on urban rail transit travel behavior in Chongqing, China: Social informatization as mediating variables
The rapid development of mobile internet technology and the widespread adoption of smartphones have significantly influenced people’s daily lives and complicated the mechanisms affecting urban rail tr...
A multilayered genetic structure analysis between inflammatory bowel disease and bone density/osteoporosis
Background The association between inflammatory bowel disease (IBD) and reduced bone mineral density (BMD) or osteoporosis is still a subject of ongoing debate, underscoring the ne...
The intersection of food insecurity and child health: Implications for policy and practice in the Bronx
Background Food insecurity, a significant stressor for many US families and children, is strongly associated with poverty and increases the risk of adverse physical and mental heal...
Association of Framingham Steatosis Index with Albuminuria: A cross-sectional study
Background The Framingham Steatosis Index (FSI) is a diagnostic indicator of hepatic steatosis. Although prior studies have established associations between hepatic steatosis and c...
Clinical utility of circulating tumor DNA for early detection of recurrence after curative hepatectomy in patients with colorectal cancer with liver metastases: A prospective observational study protocol (CASSIOPEIA)
Colorectal cancer (CRC) with liver-only metastases remains a significant clinical challenge owing to its high recurrence rate, even after curative hepatectomy. Despite advancements in surgical techniq...
Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation
Chemokines play an important role in the pathogenesis of skin diseases, such as psoriasis, atopic dermatitis, vitiligo, and alopecia areata. Recently literature data supports the theory that alternati...
Inter-examiner repeatability of measuring phorias using three different methods: Neurolens measurement device, the von Graefe method, and prism cover test
Objective Heterophoria is routinely measured during a comprehensive ocular examination. The aim of the current study is to compare the inter-examiner repeatability of the Neurolens...
Finite element analysis of progressive collapse resistance of a prefabricated RC frame structure with stud connection considering chloride corrosion
To evaluate and ensure the safety of a prefabricated connection scheme for future engineering applications, this study investigates the life-cycle progressive collapse resistance of prefabricated rein...
Nursing perspectives on advancing language access in the emergency department: A qualitative study
Objective Failure to provide language services in health care settings negatively impacts patients with non-English language preferences (NELPs), yet underuse of language assistanc...
The role and mechanism of irisin/NLRP3 signal in aerobic exercise ameliorating blood glucose homeostasis in pre-diabetic mice
Pre-diabetic mellitus (PDM) is characterized by chronic low-grade inflammation, primarily driven by NLRP3 inflammasome hyperactivation and a concurrent deficiency of the myokine irisin. MCC950 is a hi...
Perceived severity of forward versus backward balance disturbances during walking in young and older adults
Falls, which often result from trips or slips, pose a major health concern, particularly among older adults. Experiencing falls or near-falls from balance disturbances can shape subsequent gait-relate...